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ONTOLOGY REPORT - ANNOTATIONS


Term:tRNA-specific ribonuclease activity
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Accession:GO:0004549 term browser browse the term
Definition:Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules.
Synonyms:exact_synonym: tRNA-specific RNase activity
 xref: reactome:R-HSA-5696813 "TSEN complex cleaves the intron from pre-tRNA";   reactome:R-HSA-5696815 "ELAC2 cleaves the 3' end of pre-tRNA";   reactome:R-HSA-6785722 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript";   reactome:R-HSA-6786854 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript"



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tRNA-specific ribonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ang angiogenin enables ISO (PMID:19332886), (PMID:20129916), (PMID:21855800), (PMID:27518564), (PMID:29100074), (PMID:29748193), (PMID:31582561), (PMID:32510170), (PMID:38718836)
(PMID:24752898), (PMID:33986151)
RGD PMID:19332886 PMID:20129916 PMID:21855800 PMID:24752898 PMID:27518564 More... NCBI chr15:26,786,233...26,796,883 JBrowse link
G Elac1 elaC ribonuclease Z 1 enables ISO (PMID:32075755) RGD PMID:32075755 NCBI chr18:67,321,231...67,341,358
Ensembl chr18:67,323,583...67,340,936
JBrowse link
G Elac2 elaC ribonuclease Z 2 enables ISO (PMID:12711671), (PMID:15317868), (PMID:16361254), (PMID:18809514), (PMID:21559454), (PMID:21593607) RGD PMID:12711671 PMID:15317868 PMID:16361254 PMID:18809514 PMID:21559454 More... NCBI chr10:50,131,449...50,154,755
Ensembl chr10:49,632,378...49,655,614
JBrowse link
ribonuclease P activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pop1 POP1 homolog, ribonuclease P/MRP subunit contributes_to ISO (PMID:30454648), (PMID:8918471) RGD PMID:8918471 PMID:30454648 NCBI chr 7:67,590,502...67,618,187
Ensembl chr 7:65,705,368...65,733,141
JBrowse link
G Pop4 POP4 homolog, ribonuclease P/MRP subunit contributes_to ISS
ISO
GO_REF:0000024
(PMID:30454648)
UniProt
RGD
PMID:30454648 GO_REF:0000024 NCBI chr 1:100,096,722...100,105,056
Ensembl chr 1:90,960,022...90,968,443
JBrowse link
G Pop5 POP5 homolog, ribonuclease P/MRP subunit contributes_to
enables
ISO (PMID:30454648)
(PMID:11413139)
RGD PMID:11413139 PMID:30454648 NCBI chr12:47,037,451...47,045,778
Ensembl chr12:41,376,755...41,381,336
JBrowse link
G Pop7 POP7 homolog, ribonuclease P/MRP subunit contributes_to ISO (PMID:30454648) RGD PMID:30454648 NCBI chr12:24,826,161...24,827,202
Ensembl chr12:19,189,138...19,190,674
JBrowse link
G Prorp protein only RNase P catalytic subunit enables ISS
IBA
ISO
GO_REF:0000024
GO_REF:0000033
(PMID:25953853)
UniProt
GO_Central
RGD
PMID:25953853 GO_REF:0000024 GO_REF:0000033 NCBI chr 6:78,404,821...78,497,562
Ensembl chr 6:72,670,847...72,762,416
JBrowse link
G Rpp14 ribonuclease P/MRP subunit p14 contributes_to ISO (PMID:30454648) RGD PMID:30454648 NCBI chr15:16,837,796...16,847,970
Ensembl chr15:16,836,859...16,852,101
Ensembl chr15:16,836,859...16,852,101
JBrowse link
G Rpp21 ribonuclease P/MRP subunit p21 contributes_to ISO (PMID:30454648) RGD PMID:30454648 NCBI chr20:2,018,170...2,020,100
Ensembl chr20:2,018,147...2,020,106
JBrowse link
G Rpp25 ribonuclease P and MRP subunit p25 contributes_to ISS
ISO
GO_REF:0000024
(PMID:30454648)
UniProt
RGD
PMID:30454648 GO_REF:0000024 NCBI chr 8:66,803,262...66,804,642
Ensembl chr 8:57,907,352...57,908,732
JBrowse link
G Rpp30 ribonuclease P/MRP subunit p30 contributes_to ISO (PMID:30454648) RGD PMID:30454648 NCBI chr 1:233,786,048...233,808,958
Ensembl chr 1:233,786,099...233,808,952
JBrowse link
G Rpp38 ribonuclease P/MRP subunit p38 contributes_to ISO
IBA
(PMID:30454648)
GO_REF:0000033
RGD
GO_Central
PMID:30454648 GO_REF:0000033 NCBI chr17:79,823,237...79,826,908
Ensembl chr17:74,908,932...74,927,431
JBrowse link
G Rpp40 ribonuclease P/MRP subunit p40 contributes_to
enables
ISO
IBA
IEA
(PMID:30454648)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:30454648 GO_REF:0000033 GO_REF:0000107 NCBI chr17:29,153,203...29,162,241
Ensembl chr17:28,947,734...28,956,788
JBrowse link
tRNA-intron endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tsen2 tRNA splicing endonuclease subunit 2 enables IEA
IBA
GO_REF:0000002
GO_REF:0000033
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 4:150,275,389...150,310,846
Ensembl chr 4:148,602,863...148,638,215
JBrowse link
G Tsen34 tRNA splicing endonuclease subunit 34 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:74,432,687...74,440,553
Ensembl chr 1:65,517,330...65,524,412
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21090
    catalytic activity 6125
      catalytic activity, acting on a nucleic acid 632
        catalytic activity, acting on RNA 391
          RNA nuclease activity 138
            tRNA-specific ribonuclease activity 16
              ribonuclease P activity 11
              tRNA-intron endonuclease activity 2
Path 2
Term Annotations click to browse term
  molecular_function 21090
    catalytic activity 6125
      hydrolase activity 2608
        hydrolase activity, acting on ester bonds 823
          nuclease activity 232
            RNA nuclease activity 138
              tRNA-specific ribonuclease activity 16
                ribonuclease P activity 11
                tRNA-intron endonuclease activity 2
paths to the root