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ONTOLOGY REPORT - ANNOTATIONS


Term:ribonuclease III activity
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Accession:GO:0004525 term browser browse the term
Definition:Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
Synonyms:narrow_synonym: pre-mRNA 3'-end processing endonuclease
 related_synonym: RNase III activity;   ribonuclease 3 activity
 xref: EC:3.1.26.3;   MetaCyc:3.1.26.3-RXN;   Reactome:R-HSA-9708292 "DICER1 cleaves tRNA";   Reactome:R-HSA-9708408 "DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid";   Reactome:R-HSA-9820840 "DICER1 hydrolyzes maternal mRNA:lncRNA to yield endosiRNA";   reactome:R-HSA-203862 "Dicer cleaves pre-miRNA to yield duplex miRNA";   reactome:R-HSA-203893 "Microprocessor complex cleaves pri-miRNA to pre-miRNA";   reactome:R-HSA-426464 "Dicer cleaves double-stranded RNA to yield double-stranded siRNA"



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ribonuclease III activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dicer1 dicer 1 ribonuclease III enables ISO
IBA
(PMID:12411504), (PMID:12411505), (PMID:21753850)
GO_REF:0000033
RGD
GO_Central
PMID:12411504 PMID:12411505 PMID:21753850 GO_REF:0000033 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965
JBrowse link
G Drosha drosha ribonuclease III enables ISO
IBA
(PMID:14508493), (PMID:15574589)
GO_REF:0000033
RGD
GO_Central
PMID:14508493 PMID:15574589 GO_REF:0000033 NCBI chr 2:61,864,886...61,976,688
Ensembl chr 2:61,864,970...61,976,688
JBrowse link
G Mrpl44 mitochondrial ribosomal protein L44 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:81,106,658...81,111,709
Ensembl chr 9:81,106,655...81,112,812
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20893
    catalytic activity 6119
      catalytic activity, acting on a nucleic acid 638
        catalytic activity, acting on RNA 399
          RNA nuclease activity 139
            double-stranded RNA-specific ribonuclease activity 3
              ribonuclease III activity 3
                bidentate ribonuclease III activity 0
Path 2
Term Annotations click to browse term
  molecular_function 20893
    catalytic activity 6119
      hydrolase activity 2631
        hydrolase activity, acting on ester bonds 837
          nuclease activity 232
            endonuclease activity 134
              RNA endonuclease activity 73
                RNA endonuclease activity, producing 5'-phosphomonoesters 33
                  ribonuclease III activity 3
                    bidentate ribonuclease III activity 0
paths to the root