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ONTOLOGY REPORT - ANNOTATIONS

Term:ribonuclease III activity
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Accession:GO:0004525 term browser browse the term
Definition:Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
Synonyms:narrow_synonym: pre-mRNA 3'-end processing endonuclease
 related_synonym: RNase III activity;   ribonuclease 3 activity
 xref: EC:3.1.26.3;   MetaCyc:3.1.26.3-RXN;   Reactome:R-HSA-9708292 "DICER1 cleaves tRNA";   Reactome:R-HSA-9708408 "DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid";   Reactome:R-HSA-9820840 "DICER1 hydrolyzes maternal mRNA:lncRNA to yield endosiRNA";   reactome:R-HSA-203862 "Dicer cleaves pre-miRNA to yield duplex miRNA";   reactome:R-HSA-203893 "Microprocessor complex cleaves pri-miRNA to pre-miRNA";   reactome:R-HSA-426464 "Dicer cleaves double-stranded RNA to yield double-stranded siRNA"


show annotations for term's descendants           Sort by:
ribonuclease III activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DICER1 dicer 1, ribonuclease III enables IDA
IBA
IEA
TAS
EXP		 (PMID:21753850)
(PMID:12411504), (PMID:12411505)		 BHF-UCL
GO_Central
TreeGrafter
InterPro
Reactome
UniProt		 PMID:12411504 PMID:12411505 PMID:21753850 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000118 Reactome:R-HSA-9708408 NCBI chr14:95,086,228...95,158,010
Ensembl chr14:95,086,228...95,158,010 		JBrowse link
G DROSHA drosha ribonuclease III enables IDA
IEA
IBA		 (PMID:14508493), (PMID:15574589) WB
UniProt
InterPro
GO_Central		 PMID:14508493 PMID:15574589 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 NCBI chr 5:31,400,494...31,532,093
Ensembl chr 5:31,400,494...31,532,196 		JBrowse link
G MRPL44 mitochondrial ribosomal protein L44 NOT|enables IKR (PMID:11551941) FlyBase PMID:11551941 NCBI chr 2:223,950,854...223,967,714
Ensembl chr 2:223,957,463...223,967,714 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19566
    catalytic activity 5977
      catalytic activity, acting on a nucleic acid 655
        catalytic activity, acting on RNA 419
          RNA nuclease activity 134
            double-stranded RNA-specific ribonuclease activity 3
              ribonuclease III activity 3
                bidentate ribonuclease III activity 0
Path 2
Term Annotations click to browse term
  molecular_function 19566
    catalytic activity 5977
      hydrolase activity 2627
        hydrolase activity, acting on ester bonds 844
          nuclease activity 251
            endonuclease activity 137
              RNA endonuclease activity 77
                RNA endonuclease activity, producing 5'-phosphomonoesters 34
                  ribonuclease III activity 3
                    bidentate ribonuclease III activity 0
paths to the root