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ONTOLOGY REPORT - ANNOTATIONS


Term:ribonuclease III activity
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Accession:GO:0004525 term browser browse the term
Definition:Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
Synonyms:exact_synonym: RNase III activity;   ribonuclease 3 activity
 narrow_synonym: pre-mRNA 3'-end processing endonuclease
 xref: EC:3.1.26.3;   MetaCyc:3.1.26.3-RXN;   reactome:R-HSA-203862 "Dicer cleaves pre-miRNA to yield duplex miRNA";   reactome:R-HSA-203893 "Microprocessor complex cleaves pri-miRNA to pre-miRNA";   reactome:R-HSA-426464 "Dicer cleaves double-stranded RNA to yield double-stranded siRNA"


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ribonuclease III activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dgcr8 DGCR8 microprocessor complex subunit JBrowse link NW_004955442 17,998,565 18,034,247 RGD:9068941
G Dicer1 dicer 1, ribonuclease III JBrowse link NW_004955438 17,374,899 17,431,599 RGD:9068941
G Drosha drosha ribonuclease III JBrowse link NW_004955426 17,387,595 17,505,126 RGD:9068941
G Mrpl44 mitochondrial ribosomal protein L44 JBrowse link NW_004955453 10,089,547 10,097,634 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14651
    catalytic activity 5205
      catalytic activity, acting on RNA 368
        ribonuclease activity 110
          double-stranded RNA-specific ribonuclease activity 4
            ribonuclease III activity 4
              bidentate ribonuclease III activity 0
Path 2
Term Annotations click to browse term
  molecular_function 14651
    catalytic activity 5205
      hydrolase activity 2262
        hydrolase activity, acting on ester bonds 701
          nuclease activity 203
            endonuclease activity 116
              endoribonuclease activity 57
                endoribonuclease activity, producing 5'-phosphomonoesters 29
                  ribonuclease III activity 4
                    bidentate ribonuclease III activity 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.