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ONTOLOGY REPORT - ANNOTATIONS


Term:RNA-DNA hybrid ribonuclease activity
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Accession:GO:0004523 term browser browse the term
Definition:Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
Comment:Note that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species.
Synonyms:exact_synonym: RNA*DNA hybrid ribonucleotidohydrolase activity;   RNase H activity;   calf thymus ribonuclease H activity;   hybrid nuclease activity;   hybrid ribonuclease activity;   hybridase (ribonuclease H);   hybridase activity;   ribonuclease H activity
 narrow_synonym: RNase H1 activity;   RNase H2 activity;   RNase H3 activity;   endoribonuclease0 H activity;   ribonuclease H1 activity;   ribonuclease H2 activity;   ribonuclease H3 activity
 related_synonym: endoribonuclease H;   endoribonuclease H (calf thymus)
 alt_id: GO:0004524
 xref: EC:3.1.26.4;   MetaCyc:3.1.26.4-RXN;   reactome:R-HSA-164519 "RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex";   reactome:R-HSA-164528 "RNase H-mediated cleavage of the template strand";   reactome:R-HSA-173769 "RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers";   reactome:R-HSA-182795 "RNase H-mediated degradation of the template strand";   reactome:R-HSA-182859 "RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex"


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RNA-DNA hybrid ribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fen1 flap structure-specific endonuclease 1 JBrowse link 1 226,251,516 226,256,160 RGD:1624291
RGD:13792537
G Rnaseh1 ribonuclease H1 JBrowse link 6 47,916,188 47,925,582 RGD:1624291
RGD:13792537
RGD:1600115
G Rnaseh2a ribonuclease H2, subunit A JBrowse link 19 26,074,980 26,084,780 RGD:1624291
RGD:13792537
RGD:1600115
G Rnaseh2b ribonuclease H2, subunit B JBrowse link 15 45,422,010 45,472,792 RGD:1624291
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19619
    catalytic activity 6006
      catalytic activity, acting on RNA 357
        ribonuclease activity 121
          endoribonuclease activity 63
            endoribonuclease activity, producing 5'-phosphomonoesters 28
              RNA-DNA hybrid ribonuclease activity 4
Path 2
Term Annotations click to browse term
  molecular_function 19619
    catalytic activity 6006
      hydrolase activity 2595
        hydrolase activity, acting on ester bonds 782
          nuclease activity 212
            endonuclease activity 121
              endoribonuclease activity 63
                endoribonuclease activity, producing 5'-phosphomonoesters 28
                  RNA-DNA hybrid ribonuclease activity 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.