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ONTOLOGY REPORT - ANNOTATIONS


Term:endoribonuclease activity
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Accession:GO:0004521 term browser browse the term
Definition:Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
Synonyms:related_synonym: endonuclease G activity
 xref: reactome:R-HSA-425923 "IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced";   reactome:R-HSA-426520 "Endonucleolytic RISC hydrolyzes target RNAs";   reactome:R-HSA-5601887 "PLD6 dimer cleaves primary piRNA transcript to pre-piRNA";   reactome:R-HSA-5601910 "Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA";   reactome:R-HSA-6791223 "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol";   reactome:R-HSA-6814555 "Integrator complex processes the 3' end of snRNA";   reactome:R-HSA-9009936 "RNASEL cleaves cellular ssRNA";   reactome:R-HSA-9009941 "RNASEL cleaves viral ssRNA";   reactome:R-HSA-9023909 "C3PO hydrolyzes cleaved passenger strand";   reactome:R-HSA-9023912 "AGO2 cleaves passenger strand of duplex siRNA";   reactome:R-HSA-927836 "SMG6 hydrolyzes mRNA with premature termination codon"


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endoribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AGO1 argonaute RISC component 1 JBrowse link 1 35,869,808 35,930,532 RGD:2290271
G AGO2 argonaute RISC catalytic component 2 JBrowse link 8 140,520,156 140,642,406 RGD:2290271
G AGO3 argonaute RISC catalytic component 3 JBrowse link 1 35,925,683 36,072,500 RGD:2290271
G AL159163.1 novel protein RGD:2290271
G CPSF3 cleavage and polyadenylation specific factor 3 JBrowse link 2 9,423,537 9,473,110 RGD:2290271
G DICER1 dicer 1, ribonuclease III JBrowse link 14 95,086,228 95,158,263 RGD:2290271
G ENDOG endonuclease G JBrowse link 9 128,818,402 128,822,676 RGD:2290271
G ENDOU endonuclease, poly(U) specific JBrowse link 12 47,709,734 47,725,490 RGD:2290271
G ERN1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 17 64,039,142 64,132,469 RGD:2290271
G ERN2 endoplasmic reticulum to nucleus signaling 2 JBrowse link 16 23,690,310 23,713,248 RGD:2290271
G EXOG exo/endonuclease G JBrowse link 3 38,496,127 38,526,305 RGD:2290271
G LACTB2 lactamase beta 2 JBrowse link 8 70,637,266 70,669,185 RGD:2290271
G NOB1 NIN1 (RPN12) binding protein 1 homolog JBrowse link 16 69,741,854 69,754,968 RGD:2290271
G PIWIL1 piwi like RNA-mediated gene silencing 1 JBrowse link 12 130,337,887 130,412,708 RGD:2290271
G PIWIL2 piwi like RNA-mediated gene silencing 2 JBrowse link 8 22,275,314 22,357,568 RGD:2290271
G PIWIL4 piwi like RNA-mediated gene silencing 4 JBrowse link 11 94,567,368 94,621,421 RGD:2290271
G RCL1 RNA terminal phosphate cyclase like 1 JBrowse link 9 4,792,834 4,861,077 RGD:2290271
G RNASEK ribonuclease K JBrowse link 17 7,012,417 7,014,533 RGD:2290271
G RNASEL ribonuclease L JBrowse link 1 182,573,634 182,589,285 RGD:2290271
G RNASET2 ribonuclease T2 JBrowse link 6 166,922,113 166,956,580 RGD:2290271
G SLFN11 schlafen family member 11 JBrowse link 17 35,350,305 35,373,914 RGD:2290271
G SLFN13 schlafen family member 13 JBrowse link 17 35,435,096 35,451,103 RGD:2290271
G SLFN14 schlafen family member 14 JBrowse link 17 35,543,985 35,560,819 RGD:2290271
G SMG6 SMG6 nonsense mediated mRNA decay factor JBrowse link 17 2,059,839 2,303,836 RGD:2290271
G SND1 staphylococcal nuclease and tudor domain containing 1 JBrowse link 7 127,652,145 128,092,593 RGD:2290271
G TSN translin JBrowse link 2 121,755,545 121,767,853 RGD:2290271
G TSNAX translin associated factor X JBrowse link 1 231,528,669 231,566,524 RGD:2290271
G TSNAX-DISC1 TSNAX-DISC1 readthrough (NMD candidate) JBrowse link 1 231,528,653 232,041,272 RGD:2290271
G YBEY ybeY metalloendoribonuclease JBrowse link 21 46,286,056 46,314,188 RGD:2290271
G ZC3H12A zinc finger CCCH-type containing 12A JBrowse link 1 37,474,518 37,484,377 RGD:2290271
3'-tRNA processing endoribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AC091551.1 novel protein RGD:2290271
G ELAC1 elaC ribonuclease Z 1 JBrowse link 18 50,968,040 50,988,121 RGD:2290271
G ELAC2 elaC ribonuclease Z 2 JBrowse link 17 12,991,612 13,018,064 RGD:2290271
endoribonuclease activity, cleaving miRNA-paired mRNA term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AGO2 argonaute RISC catalytic component 2 JBrowse link 8 140,520,156 140,642,406 RGD:2290271
G AGO3 argonaute RISC catalytic component 3 JBrowse link 1 35,925,683 36,072,500 RGD:2290271
endoribonuclease activity, cleaving siRNA-paired mRNA term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AGO2 argonaute RISC catalytic component 2 JBrowse link 8 140,520,156 140,642,406 RGD:2290271
endoribonuclease activity, producing 3'-phosphomonoesters term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RIDA reactive intermediate imine deaminase A homolog JBrowse link 8 98,102,344 98,117,171 RGD:2290271
endoribonuclease activity, producing 5'-phosphomonoesters term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ELAC1 elaC ribonuclease Z 1 JBrowse link 18 50,968,040 50,988,121 RGD:2290271
G ENDOV endonuclease V JBrowse link 17 80,415,117 80,438,086 RGD:2290271
phosphodiesterase decapping endonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EDC3 enhancer of mRNA decapping 3 JBrowse link 15 74,630,558 74,696,434 RGD:2290271
G NUDT16 nudix hydrolase 16 JBrowse link 3 131,381,671 131,388,830 RGD:2290271
G NUDT16L1 nudix hydrolase 16 like 1 JBrowse link 16 4,688,930 4,695,859 RGD:2290271
ribonuclease A activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RNASE1 ribonuclease A family member 1, pancreatic JBrowse link 14 20,801,228 20,802,844 RGD:2290271
G RNASE2 ribonuclease A family member 2 JBrowse link 14 20,955,487 20,956,436 RGD:2290271
G RNASE4 ribonuclease A family member 4 JBrowse link 14 20,684,560 20,701,216 RGD:2290271
G RNASE8 ribonuclease A family member 8 JBrowse link 14 21,057,822 21,058,455 RGD:2290271
ribonuclease III activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DGCR8 DGCR8 microprocessor complex subunit JBrowse link 22 20,080,232 20,111,877 RGD:2290271
G DICER1 dicer 1, ribonuclease III JBrowse link 14 95,086,228 95,158,263 RGD:2290271
G DROSHA drosha ribonuclease III JBrowse link 5 31,400,494 31,532,142 RGD:2290271
G MRPL44 mitochondrial ribosomal protein L44 JBrowse link 2 223,950,846 223,967,714 RGD:2290271
ribonuclease P activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G POP1 POP1 homolog, ribonuclease P/MRP subunit JBrowse link 8 98,117,293 98,159,841 RGD:2290271
G POP4 POP4 homolog, ribonuclease P/MRP subunit JBrowse link 19 29,606,283 29,617,237 RGD:2290271
G POP5 POP5 homolog, ribonuclease P/MRP subunit JBrowse link 12 120,578,764 120,581,452 RGD:2290271
G POP7 POP7 homolog, ribonuclease P/MRP subunit JBrowse link 7 100,706,121 100,707,486 RGD:2290271
G PRORP protein only RNase P catalytic subunit JBrowse link 14 35,122,303 35,277,622 RGD:2290271
G RPP14 ribonuclease P/MRP subunit p14 JBrowse link 3 58,306,245 58,324,697 RGD:2290271
G RPP21 ribonuclease P/MRP subunit p21 JBrowse link 6 30,345,156 30,346,894 RGD:2290271
G RPP25 ribonuclease P and MRP subunit p25 JBrowse link 15 74,954,418 74,956,772 RGD:2290271
G RPP30 ribonuclease P/MRP subunit p30 JBrowse link 10 90,871,974 90,908,556 RGD:2290271
G RPP38 ribonuclease P/MRP subunit p38 JBrowse link 10 15,097,180 15,104,257 RGD:2290271
G RPP40 ribonuclease P/MRP subunit p40 JBrowse link 6 4,992,405 5,004,063 RGD:2290271
ribonuclease T2 activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AL159163.1 novel protein RGD:2290271
G RNASET2 ribonuclease T2 JBrowse link 6 166,922,113 166,956,580 RGD:2290271
RNA lariat debranching enzyme activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DBR1 debranching RNA lariats 1 JBrowse link 3 138,160,988 138,174,921 RGD:2290271
RNA-DNA hybrid ribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 14 20,455,226 20,457,767 RGD:2290271
G ERVK-6 endogenous retrovirus group K member 6, envelope RGD:2290271
G ERVK-7 endogenous retrovirus group K member 7 RGD:2290271
G EXO1 exonuclease 1 JBrowse link 1 241,847,967 241,889,939 RGD:2290271
G FEN1 flap structure-specific endonuclease 1 JBrowse link 11 61,792,911 61,797,238 RGD:2290271
G RNASEH1 ribonuclease H1 JBrowse link 2 3,531,813 3,558,367 RGD:2290271
G RNASEH2A ribonuclease H2 subunit A JBrowse link 19 12,802,054 12,813,645 RGD:2290271
G RNASEH2B ribonuclease H2 subunit B JBrowse link 13 50,909,678 50,970,462 RGD:2290271
G UBXN8 UBX domain protein 8 JBrowse link 8 30,729,131 30,767,006 RGD:2290271
tRNA-intron endonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TSEN2 tRNA splicing endonuclease subunit 2 JBrowse link 3 12,484,432 12,539,624 RGD:2290271
G TSEN34 tRNA splicing endonuclease subunit 34 JBrowse link 19 54,189,970 54,194,536 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17949
    catalytic activity 5934
      catalytic activity, acting on RNA 402
        ribonuclease activity 122
          endoribonuclease activity 68
            endoribonuclease activity involved in viral induction of host mRNA catabolic process 0
            endoribonuclease activity, producing 3'-phosphomonoesters + 9
            endoribonuclease activity, producing 5'-phosphomonoesters + 34
Path 2
Term Annotations click to browse term
  molecular_function 17949
    catalytic activity 5934
      hydrolase activity 2595
        hydrolase activity, acting on ester bonds 785
          nuclease activity 222
            endonuclease activity 131
              endoribonuclease activity 68
                endoribonuclease activity involved in viral induction of host mRNA catabolic process 0
                endoribonuclease activity, producing 3'-phosphomonoesters + 9
                endoribonuclease activity, producing 5'-phosphomonoesters + 34
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.