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ONTOLOGY REPORT - ANNOTATIONS

Term:RNA endonuclease activity
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Accession:GO:0004521 term browser browse the term
Definition:Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
Synonyms:exact_synonym: endoribonuclease activity
 related_synonym: endonuclease G activity
 xref: Reactome:R-HSA-9708327 "ANG cleaves tRNA to yield tRNA halves";   Reactome:R-HSA-9708812 "ELAC2 cleaves pre-tRNA to yield 3' trailer (type II tRF or tRF-1)";   reactome:R-HSA-425923 "IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced";   reactome:R-HSA-426520 "Endonucleolytic RISC hydrolyzes target RNAs";   reactome:R-HSA-5601887 "PLD6 dimer cleaves primary piRNA transcript to pre-piRNA";   reactome:R-HSA-5601910 "Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA";   reactome:R-HSA-6791223 "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol";   reactome:R-HSA-6814555 "Integrator complex processes the 3' end of snRNA";   reactome:R-HSA-9009936 "RNASEL cleaves cellular ssRNA";   reactome:R-HSA-9009941 "RNASEL cleaves viral ssRNA";   reactome:R-HSA-9023909 "C3PO hydrolyzes cleaved passenger strand";   reactome:R-HSA-9023912 "AGO2 cleaves passenger strand of duplex siRNA";   reactome:R-HSA-927836 "SMG6 hydrolyzes mRNA with premature termination codon"


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RNA endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGO1 argonaute RISC component 1 NOT|enables ISO (PMID:23809764) UniProt PMID:23809764 NCBI chr15:6,258,359...6,294,911
Ensembl chr15:6,263,882...6,295,338 		JBrowse link
G AGO2 argonaute RISC catalytic component 2 enables IEA Ensembl GO_REF:0000107 NCBI chr13:35,169,243...35,230,252
Ensembl chr13:35,180,912...35,268,577 		JBrowse link
G AGO3 argonaute RISC catalytic component 3 enables IEA Ensembl GO_REF:0000107 NCBI chr15:6,133,303...6,253,032
Ensembl chr15:6,145,895...6,253,085 		JBrowse link
G ANKZF1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr37:25,777,665...25,783,892
Ensembl chr37:25,777,713...25,783,887 		JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 ISO RGD PMID:19401441 RGD:2315668 NCBI chr15:17,786,808...17,789,422
Ensembl chr15:17,786,357...17,789,422 		JBrowse link
G CPSF3 cleavage and polyadenylation specific factor 3 enables IEA Ensembl GO_REF:0000107 NCBI chr17:6,537,404...6,576,121
Ensembl chr17:6,537,465...6,575,825 		JBrowse link
G DICER1 dicer 1, ribonuclease III enables IEA Ensembl GO_REF:0000107 NCBI chr 8:63,970,245...64,029,438
Ensembl chr 8:63,972,027...64,019,879 		JBrowse link
G DROSHA drosha ribonuclease III enables IEA UniProt GO_REF:0000117 Ensembl chr 4:75,774,005...75,892,632 JBrowse link
G DROSHA drosha ribonuclease III enables IEA Ensembl
UniProt		 GO_REF:0000107 GO_REF:0000117
G ENDOU endonuclease, poly(U) specific enables IEA InterPro
Ensembl
UniProt		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chr27:7,025,752...7,044,499
Ensembl chr27:7,028,263...7,043,475 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 9:11,930,614...12,006,724
Ensembl chr 9:11,934,965...12,006,814 		JBrowse link
G ERN2 endoplasmic reticulum to nucleus signaling 2 enables IEA InterPro GO_REF:0000002 NCBI chr 6:22,150,275...22,165,382
Ensembl chr 6:22,150,307...22,165,614 		JBrowse link
G INTS11 integrator complex subunit 11 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:56,485,690...56,498,074
Ensembl chr 5:56,485,948...56,498,017 		JBrowse link
G LACTB2 lactamase beta 2 enables IEA Ensembl GO_REF:0000107 NCBI chr29:19,723,155...19,749,147
Ensembl chr29:19,720,144...19,749,387 		JBrowse link
G MBLAC1 metallo-beta-lactamase domain containing 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 6:9,473,599...9,475,162
Ensembl chr 6:9,473,135...9,474,613
Ensembl chr 6:9,473,135...9,474,613 		JBrowse link
G NOB1 NIN1 (RPN12) binding protein 1 homolog enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chr 5:79,958,145...79,966,166
Ensembl chr 5:79,945,446...79,966,147 		JBrowse link
G PIWIL1 piwi like RNA-mediated gene silencing 1 enables IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr26:1,760,544...1,791,204
Ensembl chr26:1,761,149...1,791,185 		JBrowse link
G PIWIL2 piwi like RNA-mediated gene silencing 2 enables IEA Ensembl GO_REF:0000107 NCBI chr25:34,911,120...34,987,287
Ensembl chr25:34,912,358...34,987,339 		JBrowse link
G PIWIL4 piwi like RNA-mediated gene silencing 4 NOT|enables ISO (MGI:5319753|PMID:22020280) UniProt PMID:22020280 MGI:5319753 NCBI chr21:6,319,986...6,391,149
Ensembl chr21:6,319,987...6,366,787 		JBrowse link
G RAPGEF3 Rap guanine nucleotide exchange factor 3 enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr27:6,993,452...7,030,372
Ensembl chr27:6,993,452...7,017,316 		JBrowse link
G RNASEK ribonuclease K enables IEA InterPro GO_REF:0000002 NCBI chr 5:32,040,334...32,042,291
Ensembl chr 5:32,040,328...32,042,291 		JBrowse link
G SLFN14 schlafen family member 14 enables IEA Ensembl GO_REF:0000107 NCBI chr 9:38,091,939...38,112,042
Ensembl chr 9:38,100,691...38,110,695 		JBrowse link
G SMG6 SMG6 nonsense mediated mRNA decay factor enables IEA Ensembl GO_REF:0000107 NCBI chr 9:46,162,991...46,405,856
Ensembl chr 9:46,164,492...46,405,748 		JBrowse link
G SND1 staphylococcal nuclease and tudor domain containing 1 enables IEA UniProt
Ensembl		 GO_REF:0000104 GO_REF:0000107 NCBI chr14:8,265,051...8,685,864
Ensembl chr14:8,265,358...8,731,453 		JBrowse link
G YBEY ybeY metalloendoribonuclease enables ISO (PMID:28153719) UniProt PMID:28153719 NCBI chr31:39,559,933...39,565,775
Ensembl chr31:39,561,849...39,565,074 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A enables IEA Ensembl GO_REF:0000107 NCBI chr15:4,972,369...4,984,218
Ensembl chr15:4,972,956...4,980,371 		JBrowse link
3'-tRNA processing endoribonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ELAC2 elaC ribonuclease Z 2 enables IEA InterPro GO_REF:0000002 NCBI chr 5:36,957,901...36,978,646
Ensembl chr 5:36,958,264...36,978,606 		JBrowse link
endoribonuclease activity, cleaving miRNA-paired mRNA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGO2 argonaute RISC catalytic component 2 enables IEA Ensembl GO_REF:0000107 NCBI chr13:35,169,243...35,230,252
Ensembl chr13:35,180,912...35,268,577 		JBrowse link
G AGO3 argonaute RISC catalytic component 3 enables IEA Ensembl GO_REF:0000107 NCBI chr15:6,133,303...6,253,032
Ensembl chr15:6,145,895...6,253,085 		JBrowse link
endoribonuclease activity, cleaving siRNA-paired mRNA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGO2 argonaute RISC catalytic component 2 enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr13:35,169,243...35,230,252
Ensembl chr13:35,180,912...35,268,577 		JBrowse link
phosphodiesterase decapping endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NUDT12 nudix hydrolase 12 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:7,693,903...7,708,930
Ensembl chr 3:7,696,505...7,724,769 		JBrowse link
G NUDT16 nudix hydrolase 16 enables IEA Ensembl GO_REF:0000107 NCBI chr23:28,498,730...28,500,998
Ensembl chr23:28,498,652...28,499,998 		JBrowse link
ribonuclease III activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DICER1 dicer 1, ribonuclease III enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 8:63,970,245...64,029,438
Ensembl chr 8:63,972,027...64,019,879 		JBrowse link
G DROSHA drosha ribonuclease III enables IEA InterPro GO_REF:0000002 Ensembl chr 4:75,774,005...75,892,632 JBrowse link
G DROSHA drosha ribonuclease III enables IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107
G MRPL44 mitochondrial ribosomal protein L44 enables IEA InterPro GO_REF:0000002 NCBI chr37:29,681,751...29,689,489
Ensembl chr37:29,681,773...29,689,489 		JBrowse link
ribonuclease P activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POP1 POP1 homolog, ribonuclease P/MRP subunit contributes_to
enables		 ISO
IEA		 (PMID:30454648), (PMID:8918471) UniProt
Ensembl		 PMID:8918471 PMID:30454648 GO_REF:0000107 NCBI chr13:361,095...398,214
Ensembl chr13:361,157...396,628 		JBrowse link
G POP4 POP4 homolog, ribonuclease P/MRP subunit contributes_to
enables		 ISO
IEA		 (PMID:30454648) UniProt
Ensembl		 PMID:30454648 GO_REF:0000107 NCBI chr 1:121,809,448...121,815,811
Ensembl chr 1:121,809,701...121,815,443 		JBrowse link
G POP5 POP5 homolog, ribonuclease P/MRP subunit contributes_to
enables		 ISO
IEA		 (PMID:30454648) UniProt
Ensembl		 PMID:30454648 GO_REF:0000107 NCBI chr26:16,463,006...16,465,359
Ensembl chr26:16,462,994...16,465,221 		JBrowse link
G POP7 POP7 homolog, ribonuclease P/MRP subunit contributes_to
enables		 ISO
IEA		 (PMID:30454648) UniProt
UniProt
Ensembl		 PMID:30454648 GO_REF:0000104 GO_REF:0000107 NCBI chr 6:9,005,622...9,017,245
Ensembl chr 6:9,005,892...9,006,314 		JBrowse link
G PRORP protein only RNase P catalytic subunit enables IEA Ensembl GO_REF:0000107 NCBI chr 8:13,885,734...14,007,224 JBrowse link
G RPP14 ribonuclease P/MRP subunit p14 contributes_to ISO (PMID:30454648) UniProt PMID:30454648 NCBI chr20:32,282,225...32,290,576
Ensembl chr20:32,282,449...32,289,060 		JBrowse link
G RPP21 ribonuclease P/MRP subunit p21 contributes_to ISO (PMID:30454648) UniProt PMID:30454648 NCBI chr12:332,003...333,807
Ensembl chr12:332,079...333,806
Ensembl chr12:332,079...333,806 		JBrowse link
G RPP25 ribonuclease P and MRP subunit p25 contributes_to
enables		 ISO
IEA		 (PMID:30454648) UniProt
Ensembl		 PMID:30454648 GO_REF:0000107 NCBI chr30:37,987,516...37,988,991
Ensembl chr30:37,988,169...37,988,768 		JBrowse link
G RPP30 ribonuclease P/MRP subunit p30 contributes_to
enables		 ISO
IEA		 (PMID:30454648) UniProt
Ensembl		 PMID:30454648 GO_REF:0000107 NCBI chr28:5,535,257...5,563,820
Ensembl chr28:5,535,709...5,562,502 		JBrowse link
G RPP38 ribonuclease P/MRP subunit p38 enables
contributes_to		 IEA
ISO		 (PMID:30454648) Ensembl
UniProt		 PMID:30454648 GO_REF:0000107 NCBI chr 2:21,612,114...21,617,371
Ensembl chr 2:21,612,200...21,614,485 		JBrowse link
G RPP40 ribonuclease P/MRP subunit p40 enables
contributes_to		 IEA
ISO		 (PMID:30454648) Ensembl
UniProt		 PMID:30454648 GO_REF:0000107 NCBI chr35:5,109,324...5,119,713
Ensembl chr35:5,109,658...5,120,294 		JBrowse link
G RPPH1 ribonuclease P RNA component H1 enables IEA RNAcentral GO_REF:0000115
ribonuclease T2 activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RNASET2 ribonuclease T2 enables IEA InterPro GO_REF:0000002 NCBI chr 1:54,779,453...54,820,697 JBrowse link
RNA endonuclease activity, producing 3'-phosphomonoesters term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RIDA reactive intermediate imine deaminase A homolog ISO RGD PMID:10400702 RGD:9685547 NCBI chr13:348,744...361,063
Ensembl chr13:348,860...361,522 		JBrowse link
RNA endonuclease activity, producing 5'-phosphomonoesters term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGO2 argonaute RISC catalytic component 2 enables IEA UniProt GO_REF:0000104 NCBI chr13:35,169,243...35,230,252
Ensembl chr13:35,180,912...35,268,577 		JBrowse link
G ELAC1 elaC ribonuclease Z 1 enables IEA InterPro GO_REF:0000002 NCBI chr 1:23,931,360...23,971,516
Ensembl chr 1:23,960,723...23,969,405 		JBrowse link
G ENDOV endonuclease V enables IEA Ensembl GO_REF:0000107 NCBI chr 9:1,418,666...1,436,726
Ensembl chr 9:1,407,398...1,437,177 		JBrowse link
G PLD6 phospholipase D family member 6 enables IBA GO_Central GO_REF:0000033 NCBI chr 5:42,208,594...42,212,403
Ensembl chr 5:42,208,609...42,210,796 		JBrowse link
RNA lariat debranching enzyme activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DBR1 debranching RNA lariats 1 enables IEA Ensembl
UniProt		 GO_REF:0000107 GO_REF:0000117 NCBI chr23:34,375,691...34,388,317
Ensembl chr23:34,376,228...34,388,263 		JBrowse link
RNA-DNA hybrid ribonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FEN1 flap structure-specific endonuclease 1 enables IEA Ensembl GO_REF:0000107 NCBI chr18:54,680,627...54,686,502
Ensembl chr18:54,681,760...54,682,902 		JBrowse link
G NYNRIN NYN domain and retroviral integrase containing enables IEA InterPro GO_REF:0000002 NCBI chr 8:4,368,702...4,389,565
Ensembl chr 8:4,368,560...4,387,842 		JBrowse link
G RNASEH1 ribonuclease H1 enables IEA UniProt
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117 NCBI chr17:2,117,446...2,127,893
Ensembl chr17:2,117,446...2,127,893 		JBrowse link
G RNASEH2A ribonuclease H2 subunit A enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr20:49,345,258...49,352,944
Ensembl chr20:49,345,266...49,355,167 		JBrowse link
tRNA-intron endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TSEN2 tRNA splicing endonuclease subunit 2 enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 NCBI chr20:6,031,295...6,090,938
Ensembl chr20:6,050,357...6,207,981 		JBrowse link
G TSEN34 tRNA splicing endonuclease subunit 34 enables IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 1:103,021,519...103,027,460
Ensembl chr 1:103,021,525...103,026,643 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18563
    catalytic activity 5534
      catalytic activity, acting on a nucleic acid 580
        catalytic activity, acting on RNA 355
          RNA nuclease activity 103
            RNA endonuclease activity 54
              RNA endonuclease activity, producing 3'-phosphomonoesters + 3
              RNA endonuclease activity, producing 5'-phosphomonoesters + 29
              ribonuclease MRP activity 0
              ribonuclease T2 activity 1
Path 2
Term Annotations click to browse term
  molecular_function 18563
    catalytic activity 5534
      hydrolase activity 2360
        hydrolase activity, acting on ester bonds 716
          nuclease activity 188
            endonuclease activity 105
              RNA endonuclease activity 54
                RNA endonuclease activity, producing 3'-phosphomonoesters + 3
                RNA endonuclease activity, producing 5'-phosphomonoesters + 29
                ribonuclease MRP activity 0
                ribonuclease T2 activity 1
paths to the root