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ONTOLOGY REPORT - ANNOTATIONS

Term:RNA endonuclease activity
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Accession:GO:0004521 term browser browse the term
Definition:Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
Synonyms:exact_synonym: endoribonuclease activity
 related_synonym: endonuclease G activity
 xref: Reactome:R-HSA-9708327 "ANG cleaves tRNA to yield tRNA halves";   Reactome:R-HSA-9708812 "ELAC2 cleaves pre-tRNA to yield 3' trailer (type II tRF or tRF-1)";   reactome:R-HSA-425923 "IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced";   reactome:R-HSA-426520 "Endonucleolytic RISC hydrolyzes target RNAs";   reactome:R-HSA-5601887 "PLD6 dimer cleaves primary piRNA transcript to pre-piRNA";   reactome:R-HSA-5601910 "Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA";   reactome:R-HSA-6791223 "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol";   reactome:R-HSA-6814555 "Integrator complex processes the 3' end of snRNA";   reactome:R-HSA-9009936 "RNASEL cleaves cellular ssRNA";   reactome:R-HSA-9009941 "RNASEL cleaves viral ssRNA";   reactome:R-HSA-9023909 "C3PO hydrolyzes cleaved passenger strand";   reactome:R-HSA-9023912 "AGO2 cleaves passenger strand of duplex siRNA";   reactome:R-HSA-927836 "SMG6 hydrolyzes mRNA with premature termination codon"

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RNA endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago1 argonaute RISC component 1 NOT|enables ISO (PMID:23809764) UniProt PMID:23809764 NCBI chrNW_004955452:13,935,028...13,967,281
Ensembl chrNW_004955452:13,934,346...13,968,624 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 enables ISO (PMID:18178619)
(PMID:20424607)		 BHF-UCL
MGI		 PMID:18178619 PMID:20424607 NCBI chrNW_004955461:14,194,268...14,260,949
Ensembl chrNW_004955461:14,205,748...14,253,861 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 enables ISO (PMID:29040713) UniProt PMID:29040713 NCBI chrNW_004955452:13,977,487...14,108,729
Ensembl chrNW_004955452:13,977,481...14,094,259 		JBrowse link
G Ankzf1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 enables ISO (PMID:30244831), (PMID:31011209) UniProt PMID:30244831 PMID:31011209 NCBI chrNW_004955453:14,196,728...14,204,344
Ensembl chrNW_004955453:14,196,927...14,203,826 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 ISO RGD PMID:19401441 RGD:2315668 NCBI chrNW_004955550:1,273,170...1,275,843
Ensembl chrNW_004955550:1,273,284...1,279,743 		JBrowse link
G Cpsf3 cleavage and polyadenylation specific factor 3 enables ISO (MGI:4418605|PMID:18955505)
(PMID:30507380)		 UniProt PMID:18955505 PMID:30507380 MGI:4418605 NCBI chrNW_004955487:5,146,541...5,170,077
Ensembl chrNW_004955487:5,146,541...5,170,077 		JBrowse link
G Dicer1 dicer 1, ribonuclease III enables ISO (PMID:25549615)
(PMID:18325616), (PMID:19701182)		 BHF-UCL
AgBase		 PMID:18325616 PMID:19701182 PMID:25549615 NCBI chrNW_004955438:17,374,899...17,431,599
Ensembl chrNW_004955438:17,382,493...17,431,797 		JBrowse link
G Drosha drosha ribonuclease III enables ISO (PMID:20424607) MGI PMID:20424607 NCBI chrNW_004955426:17,387,595...17,505,126
Ensembl chrNW_004955426:17,387,534...17,502,294 		JBrowse link
G Endou endonuclease, poly(U) specific enables ISO (PMID:18936097)
(PMID:37803019)		 UniProt
FlyBase		 PMID:18936097 PMID:37803019 NCBI chrNW_004955500:6,631,749...6,653,457
Ensembl chrNW_004955500:6,632,743...6,646,657 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 enables ISO (PMID:11779465), (PMID:19328063), (PMID:21317875), (PMID:9637683)
(PMID:15601821), (PMID:25164867)		 UniProt
WB		 PMID:9637683 PMID:11779465 PMID:15601821 PMID:19328063 PMID:21317875 More... NCBI chrNW_004955478:7,720,664...7,803,662
Ensembl chrNW_004955478:7,751,830...7,799,460 		JBrowse link
G Ints11 integrator complex subunit 11 enables ISO (PMID:16239144) FlyBase PMID:16239144 NCBI chrNW_004955486:9,479,057...9,491,629
Ensembl chrNW_004955486:9,479,057...9,491,629 		JBrowse link
G Lactb2 lactamase beta 2 enables ISO (PMID:26826708) UniProt PMID:26826708 NCBI chrNW_004955444:9,059,999...9,088,705
Ensembl chrNW_004955444:9,059,572...9,088,705 		JBrowse link
G Mblac1 metallo-beta-lactamase domain containing 1 enables ISO (PMID:30507380) UniProt PMID:30507380 NCBI chrNW_004955573:745,202...747,402
Ensembl chrNW_004955573:745,202...747,402 		JBrowse link
G Nob1 NIN1 (RPN12) binding protein 1 homolog enables ISO (PMID:23439679), (PMID:23482395) Reactome PMID:23439679 PMID:23482395 NCBI chrNW_004955484:6,996,795...7,006,499
Ensembl chrNW_004955484:6,996,797...7,006,164 		JBrowse link
G Piwil1 piwi like RNA-mediated gene silencing 1 enables ISO (MGI:5316869|PMID:22121019)
(PMID:22121019), (PMID:25582079)		 UniProt
FlyBase		 PMID:22121019 PMID:25582079 MGI:5316869 NCBI chrNW_004955482:1,435,925...1,451,067
Ensembl chrNW_004955482:1,435,925...1,450,857 		JBrowse link
G Piwil2 piwi like RNA-mediated gene silencing 2 enables ISO (MGI:5908740|PMID:28633017)
(PMID:22020280), (PMID:23706823)
(PMID:28633017)
(MGI:5319753|PMID:22020280), (MGI:5501381|PMID:23706823)		 UniProt PMID:22020280 PMID:23706823 PMID:28633017 MGI:5319753 MGI:5501381 MGI:5908740 NCBI chrNW_004955403:45,737,674...45,819,478
Ensembl chrNW_004955403:45,737,674...45,819,873 		JBrowse link
G Piwil4 piwi like RNA-mediated gene silencing 4 NOT|enables ISO (MGI:5319753|PMID:22020280) UniProt PMID:22020280 MGI:5319753 NCBI chrNW_004955605:331,633...398,528 JBrowse link
G Rnasek ribonuclease K enables ISO (PMID:17881363) UniProt PMID:17881363 NCBI chrNW_004955467:9,914,907...9,917,051
Ensembl chrNW_004955467:9,914,907...9,917,051 		JBrowse link
G Slfn11 schlafen family member 11 enables ISO PMID:29563550 UniProt PMID:29563550 RGD:13601999 NCBI chrNW_004955481:9,885,798...9,900,330 JBrowse link
G Slfn14 schlafen family member 14 enables ISO (PMID:25996083)
(MGI:5705207|PMID:25996083)		 UniProt PMID:25996083 MGI:5705207 NCBI chrNW_004955481:10,037,941...10,046,549
Ensembl chrNW_004955481:10,037,941...10,046,549 		JBrowse link
G Smg6 SMG6 nonsense mediated mRNA decay factor enables ISO (PMID:19060897)
(PMID:18974281)		 UniProt PMID:18974281 PMID:19060897 NCBI chrNW_004955481:940,041...1,177,998
Ensembl chrNW_004955481:940,041...1,177,998 		JBrowse link
G Snd1 staphylococcal nuclease and tudor domain containing 1 enables ISO (PMID:28546213) UniProt PMID:28546213 NCBI chrNW_004955479:8,692,674...9,124,504
Ensembl chrNW_004955479:8,692,674...9,154,272 		JBrowse link
G Ybey ybeY metalloendoribonuclease enables ISO (PMID:28153719) UniProt PMID:28153719 NCBI chrNW_004955407:42,706,407...42,710,962
Ensembl chrNW_004955407:42,706,439...42,710,962 		JBrowse link
G Zc3h12a zinc finger CCCH-type containing 12A enables ISO (MGI:5706859|PMID:26000482), (MGI:5706911|PMID:22055188), (MGI:5751631|PMID:26255671)
(PMID:22055188), (PMID:26000482), (PMID:26255671)		 UniProt PMID:22055188 PMID:26000482 PMID:26255671 MGI:5706859 MGI:5706911 MGI:5751631 NCBI chrNW_004955452:15,306,398...15,314,959
Ensembl chrNW_004955452:15,305,775...15,314,959 		JBrowse link
endoribonuclease activity, cleaving miRNA-paired mRNA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago2 argonaute RISC catalytic component 2 enables ISO (PMID:15260970)
(PMID:22795694)		 BHF-UCL PMID:15260970 PMID:22795694 NCBI chrNW_004955461:14,194,268...14,260,949
Ensembl chrNW_004955461:14,205,748...14,253,861 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 enables ISO (PMID:29040713) UniProt PMID:29040713 NCBI chrNW_004955452:13,977,487...14,108,729
Ensembl chrNW_004955452:13,977,481...14,094,259 		JBrowse link
endoribonuclease activity, cleaving siRNA-paired mRNA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago2 argonaute RISC catalytic component 2 enables ISO (PMID:15260970), (PMID:17524464) UniProt PMID:15260970 PMID:17524464 NCBI chrNW_004955461:14,194,268...14,260,949
Ensembl chrNW_004955461:14,205,748...14,253,861 		JBrowse link
phosphodiesterase decapping endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nudt12 nudix hydrolase 12 enables ISO (PMID:31875550) UniProt PMID:31875550 NCBI chrNW_004955418:10,459,644...10,474,124
Ensembl chrNW_004955418:10,459,638...10,474,124 		JBrowse link
G Nudt16 nudix hydrolase 16 enables ISO (PMID:29483298) UniProt PMID:29483298 NCBI chrNW_004955501:7,083,068...7,085,505 JBrowse link
ribonuclease III activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dicer1 dicer 1, ribonuclease III enables ISO (PMID:12411504), (PMID:12411505)
(PMID:21753850)		 Reactome
BHF-UCL		 PMID:12411504 PMID:12411505 PMID:21753850 NCBI chrNW_004955438:17,374,899...17,431,599
Ensembl chrNW_004955438:17,382,493...17,431,797 		JBrowse link
G Drosha drosha ribonuclease III enables ISO (PMID:14508493), (PMID:15574589) WB PMID:14508493 PMID:15574589 NCBI chrNW_004955426:17,387,595...17,505,126
Ensembl chrNW_004955426:17,387,534...17,502,294 		JBrowse link
ribonuclease P activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pop1 POP1 homolog, ribonuclease P/MRP subunit contributes_to ISO (PMID:30454648), (PMID:8918471) UniProt PMID:8918471 PMID:30454648 NCBI chrNW_004955417:13,823,027...13,856,448
Ensembl chrNW_004955417:13,823,057...13,856,448 		JBrowse link
G Pop4 POP4 homolog, ribonuclease P/MRP subunit contributes_to ISO (PMID:30454648) UniProt PMID:30454648 NCBI chrNW_004955468:7,983,394...7,994,863
Ensembl chrNW_004955468:7,983,394...7,994,453 		JBrowse link
G Pop5 POP5 homolog, ribonuclease P/MRP subunit contributes_to
enables		 ISO (PMID:30454648)
(PMID:11413139)		 UniProt
MGI		 PMID:11413139 PMID:30454648 NCBI chrNW_004955455:11,069,131...11,071,814
Ensembl chrNW_004955455:11,069,131...11,071,814 		JBrowse link
G Pop7 POP7 homolog, ribonuclease P/MRP subunit contributes_to ISO (PMID:30454648) UniProt PMID:30454648 NCBI chrNW_004955573:217,809...218,915
Ensembl chrNW_004955573:215,932...218,976 		JBrowse link
G Prorp protein only RNase P catalytic subunit enables ISO (PMID:25953853) UniProt PMID:25953853 NCBI chrNW_004955409:25,791,209...25,920,651
Ensembl chrNW_004955409:25,791,575...25,920,077 		JBrowse link
G Rpp14 ribonuclease P/MRP subunit p14 contributes_to ISO (PMID:30454648) UniProt PMID:30454648 NCBI chrNW_004955430:1,794,460...1,802,527
Ensembl chrNW_004955430:1,794,460...1,802,527 		JBrowse link
G Rpp21 ribonuclease P/MRP subunit p21 contributes_to ISO (PMID:30454648) UniProt PMID:30454648 NCBI chrNW_004955583:467,197...468,564
Ensembl chrNW_004955583:467,256...468,513 		JBrowse link
G Rpp25 ribonuclease P and MRP subunit p25 contributes_to ISO (PMID:30454648) UniProt PMID:30454648 NCBI chrNW_004955450:3,026,257...3,027,683
Ensembl chrNW_004955450:3,026,502...3,027,065 		JBrowse link
G Rpp30 ribonuclease P/MRP subunit p30 contributes_to ISO (PMID:30454648) UniProt PMID:30454648 NCBI chrNW_004955425:2,276,006...2,302,882
Ensembl chrNW_004955425:2,273,980...2,303,314 		JBrowse link
G Rpp38 ribonuclease P/MRP subunit p38 contributes_to ISO (PMID:30454648) UniProt PMID:30454648 NCBI chrNW_004955429:19,358,765...19,360,973
Ensembl chrNW_004955429:19,358,765...19,360,973 		JBrowse link
G Rpp40 ribonuclease P/MRP subunit p40 contributes_to ISO (PMID:30454648) UniProt PMID:30454648 NCBI chrNW_004955465:8,540,500...8,550,255
Ensembl chrNW_004955465:8,540,459...8,550,249 		JBrowse link
RNA endonuclease activity, producing 3'-phosphomonoesters term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rida reactive intermediate imine deaminase A homolog ISO RGD PMID:10400702 RGD:9685547 NCBI chrNW_004955417:13,810,596...13,822,982
Ensembl chrNW_004955417:13,810,596...13,822,982 		JBrowse link
RNA endonuclease activity, producing 5'-phosphomonoesters term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endov endonuclease V enables ISO (PMID:23912683), (PMID:23912718), (PMID:27573237), (PMID:3170309) UniProt PMID:3170309 PMID:23912683 PMID:23912718 PMID:27573237 NCBI chrNW_004955506:2,483,409...2,495,484
Ensembl chrNW_004955506:2,483,409...2,495,484 		JBrowse link
RNA-DNA hybrid ribonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fen1 flap structure-specific endonuclease 1 enables ISO (PMID:7961795) UniProt PMID:7961795 NCBI chrNW_004955511:5,918,667...5,922,506
Ensembl chrNW_004955511:5,918,667...5,922,506 		JBrowse link
G Rnaseh1 ribonuclease H1 enables ISO (PMID:21700224)
(PMID:15831789)		 UniProt
MGI		 PMID:15831789 PMID:21700224 NCBI chrNW_004955487:3,808,426...3,815,682
Ensembl chrNW_004955487:3,808,419...3,815,682 		JBrowse link
G Rnaseh2a ribonuclease H2 subunit A enables ISO (PMID:21177858) UniProt PMID:21177858 NCBI chrNW_004955415:31,884,533...31,894,159
Ensembl chrNW_004955415:31,884,533...31,898,433 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14353
    catalytic activity 3737
      catalytic activity, acting on a nucleic acid 410
        catalytic activity, acting on RNA 249
          RNA nuclease activity 86
            RNA endonuclease activity 42
              RNA endonuclease activity, producing 3'-phosphomonoesters + 1
              RNA endonuclease activity, producing 5'-phosphomonoesters + 21
              ribonuclease MRP activity 0
              ribonuclease T2 activity 0
Path 2
Term Annotations click to browse term
  molecular_function 14353
    catalytic activity 3737
      hydrolase activity 1329
        hydrolase activity, acting on ester bonds 556
          nuclease activity 149
            endonuclease activity 79
              RNA endonuclease activity 42
                RNA endonuclease activity, producing 3'-phosphomonoesters + 1
                RNA endonuclease activity, producing 5'-phosphomonoesters + 21
                ribonuclease MRP activity 0
                ribonuclease T2 activity 0
paths to the root