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ONTOLOGY REPORT - ANNOTATIONS


Term:endodeoxyribonuclease activity
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Accession:GO:0004520 term browser browse the term
Definition:Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
Synonyms:related_synonym: DNA nicking activity;   endonuclease G activity
 xref: reactome:R-HSA-110359 "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site";   reactome:R-HSA-5686440 "MUS81:EME1,EME2 cleaves D-loop";   reactome:R-HSA-5686657 "ERCC1:XPF cleaves flaps generated by SSA";   reactome:R-HSA-5687464 "MRN and RBBP8 resect DNA DSBs in MMEJ";   reactome:R-HSA-5690988 "3'-incision of DNA by ERCC5 (XPG) in GG-NER";   reactome:R-HSA-5693584 "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)";   reactome:R-HSA-5693608 "Initial resection of double-strand break ends";   reactome:R-HSA-6782204 "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER";   reactome:R-HSA-6782224 "3' incision by ERCC5 (XPG) in TC-NER";   reactome:R-HSA-9023941 "MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11"


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endodeoxyribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aplf aprataxin and PNKP like factor JBrowse link 4 119,514,822 119,568,764 RGD:1624291
G Bivm basic, immunoglobulin-like variable motif containing JBrowse link 9 50,884,888 50,921,133 RGD:13792537
G Dnase1l3 deoxyribonuclease 1-like 3 JBrowse link 15 18,710,492 18,736,476 RGD:728743
G Dnase2 deoxyribonuclease 2, lysosomal JBrowse link 19 26,022,855 26,025,523 RGD:70721
G Dnase2b deoxyribonuclease 2 beta JBrowse link 2 252,436,363 252,475,506 RGD:1624291
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit JBrowse link 10 2,010,140 2,037,953 RGD:1624291
RGD:1600115
G Ercc5 ERCC excision repair 5, endonuclease JBrowse link 9 50,928,847 50,970,962 RGD:1624291
RGD:13792537
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:1624291
G Rps3 ribosomal protein S3 JBrowse link 1 164,435,868 164,441,167 RGD:1624291
G Zranb3 zinc finger RANBP2-type containing 3 JBrowse link 13 44,661,375 44,812,430 RGD:1624291
RGD:13792537
3' overhang single-stranded DNA endodeoxyribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:1624291
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit JBrowse link 10 2,010,140 2,037,953 RGD:1624291
G Xrcc1 X-ray repair cross complementing 1 JBrowse link 1 81,412,635 81,441,680 RGD:1624291
G Xrcc4 X-ray repair cross complementing 4 JBrowse link 2 18,674,496 18,927,463 RGD:1624291
3'-flap endonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mus81 MUS81 structure-specific endonuclease subunit JBrowse link 1 220,862,474 220,867,973 RGD:1624291
RGD:13792537
G Slx4 SLX4 structure-specific endonuclease subunit JBrowse link 10 11,787,756 11,808,326 RGD:1624291
RGD:13792537
5'-flap endonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dna2 DNA replication helicase/nuclease 2 RGD:1600115
RGD:13792537
G Exo1 exonuclease 1 JBrowse link 13 93,936,989 93,962,749 RGD:13792537
G Fan1 FANCD2 and FANCI associated nuclease 1 JBrowse link 1 125,182,117 125,209,772 RGD:1624291
RGD:13792537
G Fen1 flap structure-specific endonuclease 1 JBrowse link 1 226,251,516 226,256,160 RGD:1624291
RGD:13792537
G Gen1 GEN1 Holliday junction 5' flap endonuclease JBrowse link 6 36,910,064 36,940,868 RGD:1624291
RGD:13792537
G Slc25a16 solute carrier family 25 member 16 JBrowse link 20 27,283,383 27,308,069 RGD:1600115
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit JBrowse link 1 198,114,514 198,120,061 RGD:1624291
RGD:13792537
G Slx4 SLX4 structure-specific endonuclease subunit JBrowse link 10 11,787,756 11,808,326 RGD:1624291
RGD:13792537
crossover junction endodeoxyribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gen1 GEN1 Holliday junction 5' flap endonuclease JBrowse link 6 36,910,064 36,940,868 RGD:1624291
G Rad51c RAD51 paralog C JBrowse link 10 74,697,713 74,724,004 RGD:1624291
RGD:13792537
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit JBrowse link 1 198,114,514 198,120,061 RGD:1624291
RGD:13792537
G Slx4 SLX4 structure-specific endonuclease subunit JBrowse link 10 11,787,756 11,808,326 RGD:1624291
RGD:13792537
G Tefm transcription elongation factor, mitochondrial JBrowse link 10 67,476,006 67,478,830 RGD:1624291
G Xrcc3 X-ray repair cross complementing 3 JBrowse link 6 136,366,917 136,380,751 RGD:1624291
RGD:13792537
deoxyribonuclease I activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dicer1 dicer 1 ribonuclease III JBrowse link 6 128,388,084 128,453,234 RGD:13792537
G Dnase1 deoxyribonuclease 1 JBrowse link 10 11,757,681 11,760,672 RGD:1298888
RGD:13792537
RGD:1624291
G Dnase1l1 deoxyribonuclease 1-like 1 JBrowse link X 156,429,521 156,438,066 RGD:13792537
G Dnase1l2 deoxyribonuclease 1 like 2 JBrowse link 10 13,812,335 13,814,514 RGD:13792537
G Dnase1l3 deoxyribonuclease 1-like 3 JBrowse link 15 18,710,492 18,736,476 RGD:13792537
deoxyribonuclease II activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dnase2 deoxyribonuclease 2, lysosomal JBrowse link 19 26,022,855 26,025,523 RGD:13792537
G Dnase2b deoxyribonuclease 2 beta JBrowse link 2 252,436,363 252,475,506 RGD:70721
RGD:13792537
RGD:1600115
double-stranded DNA endodeoxyribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rag1 recombination activating 1 JBrowse link 3 91,206,394 91,217,491 RGD:13792537
endodeoxyribonuclease activity, producing 3'-phosphomonoesters term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Spo11 SPO11, initiator of meiotic double stranded breaks JBrowse link 3 170,991,573 171,008,226 RGD:13792537
endodeoxyribonuclease activity, producing 5'-phosphomonoesters term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Endov endonuclease V JBrowse link 10 108,630,723 108,646,679 RGD:1624291
G LOC103690794 nascent polypeptide-associated complex subunit alpha, muscle-specific form-like JBrowse link X 5,881,524 5,887,879 RGD:1600115
G Tatdn1 TatD DNase domain containing 1 JBrowse link 7 98,782,164 98,813,001 RGD:1600115
G Tatdn2 TatD DNase domain containing 2 JBrowse link 4 145,653,299 145,669,343 RGD:1600115
flap endonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Exo1 exonuclease 1 JBrowse link 13 93,936,989 93,962,749 RGD:1624291
RGD:13792537
G Fen1 flap structure-specific endonuclease 1 JBrowse link 1 226,251,516 226,256,160 RGD:1624291
RGD:13792537
G Gen1 GEN1 Holliday junction 5' flap endonuclease JBrowse link 6 36,910,064 36,940,868 RGD:13792537
single-stranded DNA endodeoxyribonuclease activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AC117889.1 RGD:13792537
G Dclre1c DNA cross-link repair 1C JBrowse link 17 78,782,512 78,812,140 RGD:1624291
G Endog endonuclease G JBrowse link 3 8,741,833 8,744,414 RGD:13792537
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:1624291
RGD:13792537
G Exog exo/endonuclease G JBrowse link 8 128,133,398 128,153,110 RGD:13792537
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:1624291
RGD:13792537
RGD:1600115
G Ptbp1 polypyrimidine tract binding protein 1 JBrowse link 7 12,663,965 12,673,723 RGD:633791
G Rad50 RAD50 double strand break repair protein JBrowse link 10 39,002,130 39,054,042 RGD:1624291
RGD:13792537
RGD:1600115
G Rbbp8 RB binding protein 8, endonuclease JBrowse link 18 3,134,630 3,227,702 RGD:1624291
RGD:13792537
G Setmar SET domain and mariner transposase fusion gene JBrowse link 4 140,092,346 140,104,495 RGD:1624291
site-specific endodeoxyribonuclease activity, specific for altered base term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 15 27,849,943 27,852,083 RGD:1600115
RGD:1624291
G Dna2 DNA replication helicase/nuclease 2 RGD:1600115
G Slc25a16 solute carrier family 25 member 16 JBrowse link 20 27,283,383 27,308,069 RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19582
    catalytic activity 5997
      catalytic activity, acting on DNA 203
        deoxyribonuclease activity 63
          endodeoxyribonuclease activity 44
            T/G mismatch-specific endonuclease activity 0
            double-stranded DNA endodeoxyribonuclease activity 1
            endodeoxyribonuclease activity, producing 3'-phosphomonoesters + 10
            endodeoxyribonuclease activity, producing 5'-phosphomonoesters + 17
            excinuclease ABC activity 0
            flap endonuclease activity + 9
            restriction endodeoxyribonuclease activity + 0
            retroviral 3' processing activity 0
            single-stranded DNA endodeoxyribonuclease activity + 13
            site-specific endodeoxyribonuclease activity, specific for altered base + 3
Path 2
Term Annotations click to browse term
  molecular_function 19582
    catalytic activity 5997
      hydrolase activity 2593
        hydrolase activity, acting on ester bonds 782
          nuclease activity 212
            endonuclease activity 121
              endodeoxyribonuclease activity 44
                T/G mismatch-specific endonuclease activity 0
                double-stranded DNA endodeoxyribonuclease activity 1
                endodeoxyribonuclease activity, producing 3'-phosphomonoesters + 10
                endodeoxyribonuclease activity, producing 5'-phosphomonoesters + 17
                excinuclease ABC activity 0
                flap endonuclease activity + 9
                restriction endodeoxyribonuclease activity + 0
                retroviral 3' processing activity 0
                single-stranded DNA endodeoxyribonuclease activity + 13
                site-specific endodeoxyribonuclease activity, specific for altered base + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.