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ONTOLOGY REPORT - ANNOTATIONS

Term:endonuclease activity
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Accession:GO:0004519 term browser browse the term
Definition:Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
Synonyms:xref: reactome:R-HSA-5358512 "MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more";   reactome:R-HSA-5358518 "MLH1:PMS2 makes single strand incision near 1-2 base mismatch";   reactome:R-HSA-5690990 "5'- incision of DNA by ERCC1:ERCC4 in GG-NER";   reactome:R-HSA-5693533 "DCLRE1C (ARTEMIS) processes DNA DSB ends";   reactome:R-HSA-72180 "Cleavage of mRNA at the 3'-end"


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endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase NOT|enables ISO (PMID:16174769) RGD PMID:16174769 NCBI chr12:42,494,187...42,500,929
Ensembl chr12:42,496,300...42,500,914 		JBrowse link
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase NOT|enables ISO (PMID:16174769) RGD PMID:16174769 NCBI chr 3:79,939,515...79,972,820
Ensembl chr 3:79,939,600...79,972,000 		JBrowse link
G Ang2 angiogenin, ribonuclease A family, member 2 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:24,398,330...24,415,909
Ensembl chr15:24,398,419...24,398,922 		JBrowse link
G Ankle1 ankyrin repeat and LEM domain containing 1 enables ISO (PMID:22399800) RGD PMID:22399800 NCBI chr16:18,076,413...18,082,356
Ensembl chr16:18,076,492...18,083,729 		JBrowse link
G Ankzf1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 9:76,688,194...76,695,162
Ensembl chr 9:76,688,194...76,696,469 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISO
IEA		 (PMID:11478795)
GO_REF:0000043		 RGD
UniProt		 PMID:11478795 GO_REF:0000043 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Apex2 apurinic/apyrimidinic endodeoxyribonuclease 2 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr  X:19,425,684...19,508,459
Ensembl chr  X:19,487,419...19,508,439 		JBrowse link
G Apex2l1 APEX nuclease (apurinic/apyrimidinic endonuclease) 2-like 1 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr14:67,166,252...67,168,138
Ensembl chr14:67,166,530...67,168,080 		JBrowse link
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease enables ISO
IBA		 (PMID:20531386)
GO_REF:0000033		 RGD
GO_Central		 PMID:20531386 GO_REF:0000033 NCBI chr15:75,820,040...75,850,450
Ensembl chr15:75,823,436...75,850,642 		JBrowse link
G Dnase1l1 deoxyribonuclease 1-like 1 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr  X:152,056,942...152,065,518
Ensembl chr  X:152,056,942...152,065,518 		JBrowse link
G Dnase1l3 deoxyribonuclease 1L3 enables ISO
IEA		 (PMID:12050166)
GO_REF:0000043		 RGD
UniProt		 PMID:12050166 GO_REF:0000043 NCBI chr15:16,922,335...16,948,322
Ensembl chr15:16,922,335...16,948,317 		JBrowse link
G Ear1 eosinophil-associated, ribonuclease A family, member 1 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:24,555,280...24,556,189
Ensembl chr15:24,555,298...24,556,199 		JBrowse link
G Ear1l1 eosinophil-associated, ribonuclease A family, member 1 like 1 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:24,486,827...24,487,702
Ensembl chr15:24,486,826...24,487,691 		JBrowse link
G ENSRNOG00000065207 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr 4:104,244,335...104,246,214 JBrowse link
G ENSRNOG00000068406 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr 4:51,689,402...51,693,026 JBrowse link
G ENSRNOG00000069140 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr 4:12,337,547...12,343,488 JBrowse link
G ENSRNOG00000070353 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr10:2,554,934...2,602,472 JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease enables ISO (PMID:32522879), (PMID:32821917) RGD PMID:32522879 PMID:32821917 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 enables ISO (MGI:3622319|PMID:11850408)
(PMID:11850408)		 RGD PMID:11850408 MGI:3622319 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Ern2 endoplasmic reticulum to nucleus signaling 2 enables ISO (PMID:11175748) RGD PMID:11175748 NCBI chr 1:176,726,454...176,743,289
Ensembl chr 1:176,726,454...176,743,289 		JBrowse link
G Exog exo/endonuclease G enables ISO (PMID:18187503) RGD PMID:18187503 NCBI chr 8:119,184,974...119,204,819
Ensembl chr 8:119,185,136...119,204,672 		JBrowse link
G Lactb2 lactamase, beta 2 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:5,569,080...5,591,843
Ensembl chr 5:5,569,067...5,596,429 		JBrowse link
G Las1l LAS1-like, ribosome biogenesis factor enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:60,851,969...60,873,717
Ensembl chr  X:60,851,962...60,873,687 		JBrowse link
G LOC100361866 eosinophil cationic protein-like enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:24,535,701...24,536,571
Ensembl chr15:24,535,700...24,536,592 		JBrowse link
G LOC134480950 igE-binding protein-like enables IEA GO_REF:0000043 UniProt GO_REF:0000043
G Mus81 MUS81 structure-specific endonuclease subunit enables ISO (PMID:19595721) RGD PMID:19595721 NCBI chr 1:202,790,295...202,796,008
Ensembl chr 1:202,790,466...202,795,843 		JBrowse link
G N4bp2 NEDD4 binding protein 2 enables ISO
IBA		 (PMID:12730195)
GO_REF:0000033		 RGD
GO_Central		 PMID:12730195 GO_REF:0000033 NCBI chr14:42,342,690...42,479,861
Ensembl chr14:42,409,510...42,483,960 		JBrowse link
G Neil1 nei-like DNA glycosylase 1 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 8:57,550,142...57,556,884
Ensembl chr 8:57,550,147...57,556,258 		JBrowse link
G Rag1 recombination activating 1 enables ISO (MGI:4441118|PMID:19396172), (MGI:4441148|PMID:10601033)
(PMID:10601033), (PMID:19396172)		 RGD PMID:10601033 PMID:19396172 MGI:4441118 MGI:4441148 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
G Rbbp8 RB binding protein 8, endonuclease enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846 		JBrowse link
G Rexo4 REX4 homolog, 3'-5' exonuclease enables ISO (PMID:21602889) RGD PMID:21602889 NCBI chr 3:10,280,654...10,291,003
Ensembl chr 3:10,280,654...10,290,996 		JBrowse link
G Rnase17 ribonuclease 17 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:24,499,178...24,500,140
Ensembl chr15:24,499,178...24,500,095 		JBrowse link
G Rnase1l1 ribonuclease, RNase A family, 1-like 1 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:24,338,216...24,339,934
Ensembl chr15:24,338,479...24,338,931 		JBrowse link
G Rnase2 ribonuclease A family member 2 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:24,449,618...24,450,427
Ensembl chr15:24,449,611...24,450,479 		JBrowse link
G Rnase3 ribonuclease A family member 3 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:24,511,894...24,512,764
Ensembl chr15:24,511,891...24,512,790 		JBrowse link
G Rnase4 ribonuclease A family member 4 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:24,312,765...24,330,112
Ensembl chr15:24,312,464...24,330,117 		JBrowse link
G Rnase6 ribonuclease A family member 6 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:24,354,305...24,357,289
Ensembl chr15:24,354,303...24,357,328 		JBrowse link
G Setmar SET domain and mariner transposase fusion gene enables ISO (PMID:20620605), (PMID:21491884), (PMID:22231448) RGD PMID:20620605 PMID:21491884 PMID:22231448 NCBI chr 4:141,046,058...141,058,183
Ensembl chr 4:141,046,069...141,058,197 		JBrowse link
G Snd1 staphylococcal nuclease and tudor domain containing 1 enables ISO (PMID:18453631) RGD PMID:18453631 NCBI chr 4:57,095,205...57,494,501
Ensembl chr 4:57,095,208...57,530,843 		JBrowse link
G Zfp873 zinc finger protein 873 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 7:7,926,951...7,959,822
Ensembl chr 7:7,926,957...7,951,803
Ensembl chr 7:7,926,957...7,951,803 		JBrowse link
3' overhang single-stranded DNA endodeoxyribonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aste1 asteroid homolog 1 enables ISO
IEA		 (PMID:34354233)
GO_REF:0000107		 RGD
Ensembl		 PMID:34354233 GO_REF:0000107 NCBI chr 8:106,026,570...106,044,694
Ensembl chr 8:106,026,515...106,044,430 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit contributes_to ISO (PMID:14690602) RGD PMID:14690602 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit contributes_to ISO (PMID:14690602) RGD PMID:14690602 NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 contributes_to ISO (MGI:3758502|PMID:14690602)
(PMID:14690602)		 RGD PMID:14690602 MGI:3758502 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 contributes_to ISO (MGI:3758502|PMID:14690602)
(PMID:14690602)		 RGD PMID:14690602 MGI:3758502 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808 		JBrowse link
3'-flap endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mus81 MUS81 structure-specific endonuclease subunit enables ISO
IBA
IEA		 (PMID:19595721)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:19595721 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:202,790,295...202,796,008
Ensembl chr 1:202,790,466...202,795,843 		JBrowse link
3'-tRNA processing endoribonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Elac1 elaC ribonuclease Z 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:67,321,231...67,341,358
Ensembl chr18:67,323,583...67,340,936 		JBrowse link
G Elac2 elaC ribonuclease Z 2 enables IEA
IBA		 GO_REF:0000003
GO_REF:0000033
GO_REF:0000002		 UniProt
GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 NCBI chr10:49,632,308...49,655,614
Ensembl chr10:49,632,378...49,655,614 		JBrowse link
5'-flap endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dna2 DNA replication helicase/nuclease 2 enables ISS
IBA
IEA		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000104		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Exo1 exonuclease 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Fan1 FANCD2 and FANCI associated nuclease 1 enables ISO
IBA		 (PMID:20603015), (PMID:20603016), (PMID:20603073), (PMID:24981866)
GO_REF:0000033		 RGD
GO_Central		 PMID:20603015 PMID:20603016 PMID:20603073 PMID:24981866 GO_REF:0000033 NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 enables ISO
IBA		 (PMID:11986308), (PMID:18995831), (PMID:8621570)
GO_REF:0000033		 RGD
GO_Central		 PMID:8621570 PMID:11986308 PMID:18995831 GO_REF:0000033 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003 		JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease enables ISO
IBA		 (PMID:26578604)
GO_REF:0000033		 RGD
GO_Central		 PMID:26578604 GO_REF:0000033 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401 		JBrowse link
G Slc25a16 solute carrier family 25 member 16 enables IEA
IBA
ISS		 GO_REF:0000104
GO_REF:0000033
GO_REF:0000024		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr20:25,691,474...25,717,558
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit enables ISO
IBA
IEA		 (PMID:19596235), (PMID:19596236)
GO_REF:0000033
GO_REF:0000104		 RGD
GO_Central
UniProt		 PMID:19596235 PMID:19596236 GO_REF:0000033 GO_REF:0000104 NCBI chr 1:181,286,190...181,291,739
Ensembl chr 1:181,283,921...181,291,775 		JBrowse link
class II DNA-(apurinic or apyrimidinic site) endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISO
ISS
IEA		 (PMID:11160897), (PMID:11286553), (PMID:1627644), (PMID:9804798)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:1627644 PMID:9804798 PMID:11160897 PMID:11286553 GO_REF:0000024 GO_REF:0000107 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
crossover junction DNA endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eme1 essential meiotic structure-specific endonuclease 1 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:79,586,718...79,595,515
Ensembl chr10:79,586,729...79,595,435 		JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:13,913,216...13,915,991
Ensembl chr10:13,913,221...13,915,968 		JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease enables ISO (PMID:23108668), (PMID:26578604), (PMID:26682650), (PMID:28049850) RGD PMID:23108668 PMID:26578604 PMID:26682650 PMID:28049850 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401 		JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit enables
contributes_to		 IEA
IBA		 GO_REF:0000104
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr 1:202,790,295...202,796,008
Ensembl chr 1:202,790,466...202,795,843 		JBrowse link
G Rad51c RAD51 paralog C contributes_to
enables		 ISO
IBA		 (PMID:14716019)
MGI:3707422|MGI:3707425 (PMID:17312021)
GO_REF:0000033		 RGD
GO_Central		 PMID:14716019 PMID:17312021 GO_REF:0000033 NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248 		JBrowse link
G Slx1b SLX1 homolog B, structure-specific endonuclease subunit enables ISO
IBA
IEA		 (PMID:19595721), (PMID:19596235), (PMID:19596236)
GO_REF:0000033
GO_REF:0000104		 RGD
GO_Central
UniProt		 PMID:19595721 PMID:19596235 PMID:19596236 GO_REF:0000033 GO_REF:0000104 NCBI chr 1:181,286,190...181,291,739
Ensembl chr 1:181,283,921...181,291,775 		JBrowse link
G Tefm transcription elongation factor, mitochondrial NOT|enables ISO (PMID:21278163) RGD PMID:21278163 NCBI chr10:65,119,657...65,124,233
Ensembl chr10:65,119,659...65,124,486 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 contributes_to ISO (PMID:14716019), (PMID:23108668) RGD PMID:14716019 PMID:23108668 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444 		JBrowse link
deoxyribonuclease I activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dicer1 dicer 1 ribonuclease III enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965 		JBrowse link
G Dnase1 deoxyribonuclease 1 enables IDA
ISO
IBA		 (PMID:15015938)
GO_REF:0000033
(MGI:3687616|PMID:15015938)		 RGD
GO_Central		 PMID:15015938 PMID:12005024 GO_REF:0000033 MGI:3687616, RGD:1298888 NCBI chr10:11,498,930...11,505,151
Ensembl chr10:11,498,931...11,501,869 		JBrowse link
G Dnase1l1 deoxyribonuclease 1-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:152,056,942...152,065,518
Ensembl chr  X:152,056,942...152,065,518 		JBrowse link
G Dnase1l2 deoxyribonuclease 1 like 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:13,471,850...13,473,447
Ensembl chr10:13,471,479...13,473,763 		JBrowse link
G Dnase1l3 deoxyribonuclease 1L3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:16,922,335...16,948,322
Ensembl chr15:16,922,335...16,948,317 		JBrowse link
deoxyribonuclease II activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnase2 deoxyribonuclease 2, lysosomal enables IBA
ISO
IEA		 GO_REF:0000033
(PMID:11375492)
GO_REF:0000104		 GO_Central
RGD
UniProt		 PMID:11375492 GO_REF:0000033 GO_REF:0000104 NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376 		JBrowse link
G Dnase2b deoxyribonuclease 2 beta enables IDA
IEA
IBA		 GO_REF:0000104
GO_REF:0000033
GO_REF:0000003		 UniProt
GO_Central
RGD		 PMID:10558878 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104, RGD:70721 NCBI chr 2:235,470,915...235,515,211
Ensembl chr 2:235,470,919...235,486,295 		JBrowse link
DNA endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankle1 ankyrin repeat and LEM domain containing 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:18,076,413...18,082,356
Ensembl chr16:18,076,492...18,083,729 		JBrowse link
G Aplf aprataxin and PNKP like factor enables ISO (PMID:17396150) RGD PMID:17396150 NCBI chr 4:120,070,471...120,122,656
Ensembl chr 4:120,070,471...120,122,633 		JBrowse link
G Dffb DNA fragmentation factor subunit beta enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628 		JBrowse link
G Dnase1l3 deoxyribonuclease 1L3 IDA RGD PMID:9665719 RGD:728743 NCBI chr15:16,922,335...16,948,322
Ensembl chr15:16,922,335...16,948,317 		JBrowse link
G Dnase2 deoxyribonuclease 2, lysosomal IDA RGD PMID:10558878 RGD:70721 NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376 		JBrowse link
G Dnase2b deoxyribonuclease 2 beta enables ISO (PMID:10497274) RGD PMID:10497274 NCBI chr 2:235,470,915...235,515,211
Ensembl chr 2:235,470,919...235,486,295 		JBrowse link
G Endog endonuclease G enables ISO (PMID:25355512), (PMID:29719607), (PMID:33473107)
(MGI:5617102|PMID:25355512), (MGI:6480170|PMID:32192768), (MGI:6810801|PMID:32095813)		 RGD PMID:25355512 PMID:29719607 PMID:32095813 PMID:32192768 PMID:33473107 MGI:5617102 MGI:6480170 MGI:6810801 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit contributes_to
enables		 ISO (PMID:8797827)
(PMID:10413517), (PMID:14734547), (PMID:17055345)		 RGD PMID:8797827 PMID:10413517 PMID:14734547 PMID:17055345 NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369 		JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease enables ISO
IBA		 (PMID:12644470), (PMID:8090225)
GO_REF:0000033		 RGD
GO_Central		 PMID:8090225 PMID:12644470 GO_REF:0000033 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000002
(PMID:22078559), (PMID:23080121), (PMID:24316220), (PMID:27814491), (PMID:27889449), (PMID:30787182), (PMID:9705271)		 UniProt
InterPro
RGD		 PMID:9705271 PMID:22078559 PMID:23080121 PMID:24316220 PMID:27814491 More... GO_REF:0000002 GO_REF:0000024 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G N4bp2 NEDD4 binding protein 2 enables ISO (PMID:12730195) RGD PMID:12730195 NCBI chr14:42,342,690...42,479,861
Ensembl chr14:42,409,510...42,483,960 		JBrowse link
G Rps3 ribosomal protein S3 enables ISO (PMID:15707971), (PMID:20605787) RGD PMID:15707971 PMID:20605787 NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680 		JBrowse link
G Zranb3 zinc finger RANBP2-type containing 3 enables ISO
IBA		 (PMID:22759634)
GO_REF:0000033		 RGD
GO_Central		 PMID:22759634 GO_REF:0000033 NCBI chr13:39,440,653...39,595,782
Ensembl chr13:39,440,889...39,595,670 		JBrowse link
double-stranded DNA endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rag1 recombination activating 1 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291 		JBrowse link
endodeoxyribonuclease activity, producing 5'-phosphomonoesters term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endov endonuclease V NOT|enables ISO (PMID:23139746), (PMID:23912683)
(PMID:12853604)
(MGI:5009179|PMID:12853604)		 RGD PMID:12853604 PMID:23139746 PMID:23912683 MGI:5009179 NCBI chr10:104,760,059...104,777,732
Ensembl chr10:104,760,137...104,775,969 		JBrowse link
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snd1 staphylococcal nuclease and tudor domain containing 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:57,095,205...57,494,501
Ensembl chr 4:57,095,208...57,530,843 		JBrowse link
endoribonuclease activity, cleaving miRNA-paired mRNA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago2 argonaute RISC catalytic component 2 enables IEA
ISO		 GO_REF:0000107
(PMID:15260970), (PMID:22795694)		 Ensembl
RGD		 PMID:15260970 PMID:22795694 GO_REF:0000107 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 enables ISO (PMID:29040713) RGD PMID:29040713 NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230 		JBrowse link
endoribonuclease activity, cleaving siRNA-paired mRNA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago2 argonaute RISC catalytic component 2 enables IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000002
GO_REF:0000024
(PMID:15260970), (PMID:17524464)		 Ensembl
InterPro
UniProt
RGD		 PMID:15260970 PMID:17524464 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
flap endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Exo1 exonuclease 1 enables ISO (PMID:10608837), (PMID:11842105) RGD PMID:10608837 PMID:11842105 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 enables ISO (PMID:18499658)
(PMID:12162748)		 RGD PMID:12162748 PMID:18499658 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003 		JBrowse link
phosphodiesterase decapping endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nudt12 nudix hydrolase 12 enables ISO (PMID:31875550) RGD PMID:31875550 NCBI chr 9:98,741,627...98,755,039
Ensembl chr 9:98,742,360...98,755,039 		JBrowse link
G Nudt16 nudix hydrolase 16 enables ISO
IBA		 (PMID:29483298)
GO_REF:0000033		 RGD
GO_Central		 PMID:29483298 GO_REF:0000033 NCBI chr 8:105,739,927...105,741,982
Ensembl chr 8:105,739,623...105,741,998 		JBrowse link
G Nudt16l1 nudix hydrolase 16 like 1 NOT|enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:10,636,174...10,638,090
Ensembl chr10:10,636,174...10,688,370 		JBrowse link
G Nudt16l2 nudix hydrolase 16 like 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:105,754,821...105,756,548
Ensembl chr 8:105,754,844...105,756,518 		JBrowse link
ribonuclease A activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnase1 ribonuclease A family member 1, pancreatic enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:24,361,924...24,363,633
Ensembl chr15:24,361,927...24,363,624 		JBrowse link
G Rnase1l1 ribonuclease, RNase A family, 1-like 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:24,338,216...24,339,934
Ensembl chr15:24,338,479...24,338,931 		JBrowse link
G Rnase1l2 ribonuclease, RNase A family, 1-like 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:24,421,825...24,423,513
Ensembl chr15:24,421,859...24,423,611 		JBrowse link
ribonuclease III activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dicer1 dicer 1 ribonuclease III enables ISO
IBA		 (PMID:12411504), (PMID:12411505), (PMID:21753850)
GO_REF:0000033		 RGD
GO_Central		 PMID:12411504 PMID:12411505 PMID:21753850 GO_REF:0000033 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965 		JBrowse link
G Drosha drosha ribonuclease III enables ISO
IBA		 (PMID:14508493), (PMID:15574589)
GO_REF:0000033		 RGD
GO_Central		 PMID:14508493 PMID:15574589 GO_REF:0000033 NCBI chr 2:61,864,886...61,976,688
Ensembl chr 2:61,864,970...61,976,688 		JBrowse link
G Mrpl44 mitochondrial ribosomal protein L44 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:81,106,658...81,111,709
Ensembl chr 9:81,106,655...81,112,812 		JBrowse link
ribonuclease MRP activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpp40 ribonuclease P/MRP subunit p40 contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:28,947,752...28,956,788
Ensembl chr17:28,947,734...28,956,788 		JBrowse link
ribonuclease P activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pop1 POP1 homolog, ribonuclease P/MRP subunit contributes_to ISO (PMID:30454648), (PMID:8918471) RGD PMID:8918471 PMID:30454648 NCBI chr 7:65,705,348...65,733,143
Ensembl chr 7:65,705,368...65,733,141 		JBrowse link
G Pop4 POP4 homolog, ribonuclease P/MRP subunit contributes_to ISS
ISO		 GO_REF:0000024
(PMID:30454648)		 UniProt
RGD		 PMID:30454648 GO_REF:0000024 NCBI chr 1:90,960,026...90,968,360
Ensembl chr 1:90,960,022...90,968,443 		JBrowse link
G Pop5 POP5 homolog, ribonuclease P/MRP subunit contributes_to
enables		 ISO (PMID:30454648)
(PMID:11413139)		 RGD PMID:11413139 PMID:30454648 NCBI chr12:41,376,755...41,384,882
Ensembl chr12:41,376,755...41,381,336 		JBrowse link
G Pop7 POP7 homolog, ribonuclease P/MRP subunit contributes_to ISO (PMID:30454648) RGD PMID:30454648 NCBI chr12:19,189,384...19,190,425
Ensembl chr12:19,189,138...19,190,674 		JBrowse link
G Prorp protein only RNase P catalytic subunit enables ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:25953853)		 UniProt
GO_Central
RGD		 PMID:25953853 GO_REF:0000024 GO_REF:0000033 NCBI chr 6:72,669,659...72,762,419
Ensembl chr 6:72,670,847...72,762,416 		JBrowse link
G Rpp14 ribonuclease P/MRP subunit p14 contributes_to ISO (PMID:30454648) RGD PMID:30454648 NCBI chr15:16,837,796...16,847,970
Ensembl chr15:16,836,859...16,852,101
Ensembl chr15:16,836,859...16,852,101 		JBrowse link
G Rpp21 ribonuclease P/MRP subunit p21 contributes_to ISO (PMID:30454648) RGD PMID:30454648 NCBI chr20:2,018,170...2,020,100
Ensembl chr20:2,018,147...2,020,106 		JBrowse link
G Rpp25 ribonuclease P and MRP subunit p25 contributes_to ISS
ISO		 GO_REF:0000024
(PMID:30454648)		 UniProt
RGD		 PMID:30454648 GO_REF:0000024 NCBI chr 8:57,907,352...57,908,732
Ensembl chr 8:57,907,352...57,908,732 		JBrowse link
G Rpp30 ribonuclease P/MRP subunit p30 contributes_to ISO (PMID:30454648) RGD PMID:30454648 NCBI chr 1:233,786,048...233,808,958
Ensembl chr 1:233,786,099...233,808,952 		JBrowse link
G Rpp38 ribonuclease P/MRP subunit p38 contributes_to ISO
IBA		 (PMID:30454648)
GO_REF:0000033		 RGD
GO_Central		 PMID:30454648 GO_REF:0000033 NCBI chr17:74,914,066...74,917,742
Ensembl chr17:74,908,932...74,927,431 		JBrowse link
G Rpp40 ribonuclease P/MRP subunit p40 contributes_to
enables		 ISO
IBA
IEA		 (PMID:30454648)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:30454648 GO_REF:0000033 GO_REF:0000107 NCBI chr17:28,947,752...28,956,788
Ensembl chr17:28,947,734...28,956,788 		JBrowse link
ribonuclease T2 activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnaset2 ribonuclease T2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:52,576,344...52,603,151
Ensembl chr 1:52,585,929...52,603,147 		JBrowse link
G Rnaset2-ps1 ribonuclease T2, pseudogene 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:138,600,084...138,600,943
Ensembl chr 3:138,600,187...138,600,965
Ensembl chr 3:138,600,187...138,600,965 		JBrowse link
RNA endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC118772.1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr10:68,067,119...68,089,948 JBrowse link
G Ago1 argonaute RISC component 1 NOT|enables ISO (PMID:23809764) RGD PMID:23809764 NCBI chr 5:138,722,111...138,757,118
Ensembl chr 5:138,722,111...138,773,546 		JBrowse link
G Ago2 argonaute RISC catalytic component 2 enables ISO
IBA		 (PMID:18178619)
GO_REF:0000033
(PMID:20424607)		 RGD
GO_Central		 PMID:18178619 PMID:20424607 GO_REF:0000033 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 enables ISO
IBA		 (PMID:29040713)
GO_REF:0000033		 RGD
GO_Central		 PMID:29040713 GO_REF:0000033 NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230 		JBrowse link
G Ago4 argonaute RISC component 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:138,780,446...138,825,898
Ensembl chr 5:138,783,069...138,825,632 		JBrowse link
G Ankzf1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 enables ISO
IEA
ISS		 (PMID:30244831), (PMID:31011209)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:30244831 PMID:31011209 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:76,688,194...76,695,162
Ensembl chr 9:76,688,194...76,696,469 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 IDA RGD PMID:19401441 RGD:2315668 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G C10h17orf49 similar to human chromosome 17 open reading frame 49 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:54,951,991...54,954,756
Ensembl chr10:54,951,991...54,956,601 		JBrowse link
G Cpsf3 cleavage and polyadenylation specific factor 3 enables ISO
IBA		 (MGI:4418605|PMID:18955505)
GO_REF:0000033
(PMID:30507380)		 RGD
GO_Central		 PMID:18955505 PMID:30507380 GO_REF:0000033 MGI:4418605 NCBI chr 6:40,836,121...40,864,129
Ensembl chr 6:40,836,097...40,864,128 		JBrowse link
G Dicer1 dicer 1 ribonuclease III enables ISO (PMID:18325616), (PMID:19701182), (PMID:25549615) RGD PMID:18325616 PMID:19701182 PMID:25549615 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965 		JBrowse link
G Drosha drosha ribonuclease III enables ISO (PMID:20424607) RGD PMID:20424607 NCBI chr 2:61,864,886...61,976,688
Ensembl chr 2:61,864,970...61,976,688 		JBrowse link
G Endog endonuclease G enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Endou endonuclease, poly(U)-specific enables ISO
IBA		 FB:FBgn0030251 (PMID:18936097), (PMID:37803019)
GO_REF:0000033		 RGD
GO_Central		 PMID:18936097 PMID:37803019 GO_REF:0000033 NCBI chr 7:128,844,872...128,866,572
Ensembl chr 7:128,844,862...128,866,596 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 enables ISO
IBA		 (PMID:11779465), (PMID:19328063), (PMID:21317875), (PMID:9637683)
(PMID:15601821), (PMID:25164867)
GO_REF:0000033		 RGD
GO_Central		 PMID:9637683 PMID:11779465 PMID:15601821 PMID:19328063 PMID:21317875 More... GO_REF:0000033 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Ern2 endoplasmic reticulum to nucleus signaling 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:176,726,454...176,743,289
Ensembl chr 1:176,726,454...176,743,289 		JBrowse link
G Exog exo/endonuclease G enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:119,184,974...119,204,819
Ensembl chr 8:119,185,136...119,204,672 		JBrowse link
G Ints11 integrator complex subunit 11 enables ISO
IBA
IEA		 (PMID:16239144)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:16239144 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:166,479,134...166,497,956
Ensembl chr 5:166,479,155...166,497,651 		JBrowse link
G Khnyn KH and NYN domain containing enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:29,365,399...29,379,650
Ensembl chr15:29,365,260...29,376,967 		JBrowse link
G Lactb2 lactamase, beta 2 enables ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:26826708)		 UniProt
GO_Central
RGD		 PMID:26826708 GO_REF:0000024 GO_REF:0000033 NCBI chr 5:5,569,080...5,591,843
Ensembl chr 5:5,569,067...5,596,429 		JBrowse link
G Mblac1 metallo-beta-lactamase domain containing 1 enables ISO
ISS		 (PMID:30507380)
GO_REF:0000024		 RGD
UniProt		 PMID:30507380 GO_REF:0000024 NCBI chr12:17,071,465...17,072,736
Ensembl chr12:17,071,465...17,072,735 		JBrowse link
G Nob1 NIN1 (RPN12) binding protein 1 homolog enables ISO
IBA
IEA		 (PMID:23439679), (PMID:23482395)
GO_REF:0000033
GO_REF:0000104		 RGD
GO_Central
UniProt		 PMID:23439679 PMID:23482395 GO_REF:0000033 GO_REF:0000104 NCBI chr19:35,322,803...35,335,354
Ensembl chr19:35,322,669...35,346,815 		JBrowse link
G Nynrin NYN domain and retroviral integrase containing enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:29,332,873...29,355,215
Ensembl chr15:29,332,869...29,355,215 		JBrowse link
G Piwil1 piwi-like RNA-mediated gene silencing 1 enables ISO
IBA		 (MGI:5316869|PMID:22121019)
GO_REF:0000033		 RGD
GO_Central		 PMID:22121019 GO_REF:0000033 MGI:5316869 NCBI chr12:27,949,743...27,970,645
Ensembl chr12:27,949,744...27,970,580 		JBrowse link
G Piwil2 piwi-like RNA-mediated gene silencing 2 enables ISO
IBA		 (MGI:5319753|PMID:22020280), (MGI:5501381|PMID:23706823), (MGI:5908740|PMID:28633017)
GO_REF:0000033		 RGD
GO_Central		 PMID:22020280 PMID:23706823 PMID:28633017 GO_REF:0000033 MGI:5319753 MGI:5501381 MGI:5908740 NCBI chr15:45,431,402...45,498,034
Ensembl chr15:45,431,703...45,497,702 		JBrowse link
G Piwil4 piwi-like RNA-mediated gene silencing 4 NOT|enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:22020280)
GO_REF:0000033
(MGI:5319753|PMID:22020280)		 UniProt
RGD
GO_Central		 PMID:22020280 GO_REF:0000024 GO_REF:0000033 MGI:5319753 NCBI chr 8:11,536,520...11,579,883
Ensembl chr 8:11,536,520...11,579,761 		JBrowse link
G Rcl1 RNA terminal phosphate cyclase-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:226,824,561...226,869,046
Ensembl chr 1:226,824,534...226,902,315 		JBrowse link
G Rnasek ribonuclease K enables ISO
IBA		 (PMID:17881363)
GO_REF:0000033		 RGD
GO_Central		 PMID:17881363 GO_REF:0000033 NCBI chr10:54,954,904...54,956,622
Ensembl chr10:54,951,991...54,956,601 		JBrowse link
G Rnaset2 ribonuclease T2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:52,576,344...52,603,151
Ensembl chr 1:52,585,929...52,603,147 		JBrowse link
G Slfn14 schlafen family member 14 enables ISO (PMID:25996083)
(MGI:5705207|PMID:25996083)		 RGD PMID:25996083 MGI:5705207 NCBI chr10:68,076,326...68,087,794 JBrowse link
G Slfn9 schlafen family member 9 enables IDA PMID:29563550 UniProt PMID:29563550 RGD:13601999 NCBI chr10:67,909,105...67,955,912
Ensembl chr10:67,909,106...67,925,383 		JBrowse link
G Smg6 SMG6 nonsense mediated mRNA decay factor enables ISO (PMID:18974281), (PMID:19060897) RGD PMID:18974281 PMID:19060897 NCBI chr10:59,786,258...60,014,395
Ensembl chr10:59,786,258...60,014,395 		JBrowse link
G Snd1 staphylococcal nuclease and tudor domain containing 1 enables ISO
IEA		 (PMID:28546213)
GO_REF:0000104		 RGD
UniProt		 PMID:28546213 GO_REF:0000104 NCBI chr 4:57,095,205...57,494,501
Ensembl chr 4:57,095,208...57,530,843 		JBrowse link
G Tsnax translin-associated factor X enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:52,975,848...52,989,886
Ensembl chr19:52,975,659...52,989,878 		JBrowse link
G Ybey ybeY metalloendoribonuclease enables ISO (PMID:28153719) RGD PMID:28153719 NCBI chr20:12,165,192...12,174,713
Ensembl chr20:12,165,237...12,174,713 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:22055188), (PMID:26000482), (PMID:26255671)
GO_REF:0000033
(MGI:5706859|PMID:26000482), (MGI:5706911|PMID:22055188), (MGI:5751631|PMID:26255671)		 UniProt
RGD
GO_Central		 PMID:22055188 PMID:26000482 PMID:26255671 GO_REF:0000024 GO_REF:0000033 MGI:5706859 MGI:5706911 MGI:5751631 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351 		JBrowse link
G Zc3h12b zinc finger CCCH-type containing 12B enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:60,615,616...60,849,278
Ensembl chr  X:60,615,682...60,844,832 		JBrowse link
G Zc3h12c zinc finger CCCH type containing 12C enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:52,443,791...52,508,643
Ensembl chr 8:52,448,320...52,504,315 		JBrowse link
G Zc3h12d zinc finger CCCH type containing 12D enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:2,313,110...2,348,820
Ensembl chr 1:2,314,324...2,348,819 		JBrowse link
RNA endonuclease activity, producing 3'-phosphomonoesters term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rida reactive intermediate imine deaminase A homolog IDA RGD PMID:10400702 RGD:9685547 NCBI chr 7:65,691,429...65,705,257
Ensembl chr 7:65,691,435...65,705,716 		JBrowse link
RNA endonuclease activity, producing 5'-phosphomonoesters term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endov endonuclease V enables ISO
IBA		 (PMID:23912683), (PMID:23912718), (PMID:27573237)
GO_REF:0000033
(PMID:3170309)		 RGD
GO_Central		 PMID:3170309 PMID:23912683 PMID:23912718 PMID:27573237 GO_REF:0000033 NCBI chr10:104,760,059...104,777,732
Ensembl chr10:104,760,137...104,775,969 		JBrowse link
G Pld6 phospholipase D family, member 6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:44,578,536...44,581,187
Ensembl chr10:44,577,675...44,581,077 		JBrowse link
RNA lariat debranching enzyme activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbr1 debranching RNA lariats 1 enables ISO
IBA		 (PMID:10982890), (PMID:29474921)
GO_REF:0000033		 RGD
GO_Central		 PMID:10982890 PMID:29474921 GO_REF:0000033 NCBI chr 8:100,139,039...100,150,768
Ensembl chr 8:100,139,034...100,151,030 		JBrowse link
RNA-DNA hybrid ribonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENSRNOG00000067229 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 4:83,921,470...83,930,590 JBrowse link
G ENSRNOG00000067248 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 9:77,055,483...77,060,879 JBrowse link
G ENSRNOG00000069624 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr 4:147,700,824...147,706,682 JBrowse link
G Fen1 flap structure-specific endonuclease 1 enables ISO
IBA		 (PMID:7961795)
GO_REF:0000033		 RGD
GO_Central		 PMID:7961795 GO_REF:0000033 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003 		JBrowse link
G Nynrin NYN domain and retroviral integrase containing enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr15:29,332,873...29,355,215
Ensembl chr15:29,332,869...29,355,215 		JBrowse link
G Ormdl1 ORMDL sphingolipid biosynthesis regulator 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:48,243,365...48,253,316
Ensembl chr 9:48,237,572...48,253,211 		JBrowse link
G Rnaseh1 ribonuclease H1 enables ISO
IBA
ISS		 (PMID:21700224)
(PMID:15831789)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:15831789 PMID:21700224 GO_REF:0000024 GO_REF:0000033 NCBI chr 6:45,282,849...45,292,258
Ensembl chr 6:45,282,854...45,292,236 		JBrowse link
G Rnaseh2a ribonuclease H2, subunit A enables ISO
IBA
ISS		 (PMID:21177858)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:21177858 GO_REF:0000024 GO_REF:0000033 NCBI chr19:23,186,325...23,196,045
Ensembl chr19:23,186,383...23,196,041 		JBrowse link
single-stranded DNA endodeoxyribonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aste1 asteroid homolog 1 enables ISO (PMID:34354233) RGD PMID:34354233 NCBI chr 8:106,026,570...106,044,694
Ensembl chr 8:106,026,515...106,044,430 		JBrowse link
G Dclre1c DNA cross-link repair 1C enables ISO
IEA		 (PMID:11955432)
GO_REF:0000107		 RGD
Ensembl		 PMID:11955432 GO_REF:0000107 NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186 		JBrowse link
G Endog endonuclease G enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit contributes_to ISO (PMID:7559382) RGD PMID:7559382 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369 		JBrowse link
G Ercc4l1 excision repair cross-complementing rodent repair deficiency, complementation group 4-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:954,927...983,651
Ensembl chr10:954,977...983,174 		JBrowse link
G Exog exo/endonuclease G enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:119,184,974...119,204,819
Ensembl chr 8:119,185,136...119,204,672 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease enables ISO
IBA
IEA		 (PMID:9705271)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:9705271 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279 		JBrowse link
G Ptbp1 polypyrimidine tract binding protein 1 IDA RGD PMID:12269805 RGD:633791 NCBI chr 7:9,842,574...9,852,332
Ensembl chr 7:9,842,574...9,852,397 		JBrowse link
G Rad50 RAD50 double strand break repair protein contributes_to
enables		 ISO
IEA
ISS		 (PMID:9705271)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:9705271 GO_REF:0000024 GO_REF:0000107 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396 		JBrowse link
G Rbbp8 RB binding protein 8, endonuclease enables ISO (PMID:18716619), (PMID:19202191) RGD PMID:18716619 PMID:19202191 NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846 		JBrowse link
G Setmar SET domain and mariner transposase fusion gene enables ISO (PMID:21491884), (PMID:24573677) RGD PMID:21491884 PMID:24573677 NCBI chr 4:141,046,058...141,058,183
Ensembl chr 4:141,046,069...141,058,197 		JBrowse link
site-specific endodeoxyribonuclease activity, specific for altered base term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:19188445), (PMID:24703901)		 UniProt
Ensembl
RGD		 PMID:19188445 PMID:24703901 GO_REF:0000024 GO_REF:0000107 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Dna2 DNA replication helicase/nuclease 2 enables IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr20:25,661,652...25,690,598
Ensembl chr20:25,662,055...25,716,319 		JBrowse link
tRNA-intron endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tsen2 tRNA splicing endonuclease subunit 2 enables IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 4:148,602,805...148,638,219
Ensembl chr 4:148,602,863...148,638,215 		JBrowse link
G Tsen34 tRNA splicing endonuclease subunit 34 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:65,517,324...65,525,194
Ensembl chr 1:65,517,330...65,524,412 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20732
    catalytic activity 6109
      hydrolase activity 2595
        hydrolase activity, acting on ester bonds 811
          nuclease activity 229
            endonuclease activity 134
              DNA endonuclease activity + 44
              RNA endonuclease activity + 73
              endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters + 17
              endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters + 44
paths to the root