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ONTOLOGY REPORT - ANNOTATIONS

Term:phenylalanine 4-monooxygenase activity
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Accession:GO:0004505 term browser browse the term
Definition:Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin.
Synonyms:exact_synonym: phenylalanine hydroxylase activity
 related_synonym: L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating);   PAH activity;   phenylalaninase activity;   phenylalanine 4-hydroxylase activity
 xref: EC:1.14.16.1;   MetaCyc:RXN66-569;   RHEA:20273;   Reactome:R-HSA-5649483 "Defective PAH does not hydroxylate L-Phe to L-Tyr";   Reactome:R-HSA-71118 "PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr"


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phenylalanine 4-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pah phenylalanine hydroxylase enables IDA
IEA
ISO
IBA		 GO_REF:0000116
GO_REF:0000002
GO_REF:0000003
(PMID:20667834)
GO_REF:0000117
GO_REF:0000033
MGI:1857271 (PMID:2308957)		 RHEA
InterPro
UniProt
RGD
GO_Central		 PMID:2308957 PMID:20667834 PMID:16953590 PMID:10839989 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 GO_REF:0000117, RGD:1601531, RGD:1601535 NCBI chr 7:23,793,096...23,885,631
Ensembl chr 7:21,933,179...21,998,130 		JBrowse link
G Pcbd1 pterin-4 alpha-carbinolamine dehydratase 1 enables ISO (PMID:15182178) RGD PMID:15182178 NCBI chr20:29,573,362...29,587,181
Ensembl chr20:28,953,864...29,044,292
Ensembl chr20:28,953,864...29,044,292 		JBrowse link
G Pcbd2 pterin-4 alpha-carbinolamine dehydratase 2 enables ISO (PMID:15182178) RGD PMID:15182178 NCBI chr17:8,850,349...8,902,420
Ensembl chr17:8,845,084...8,910,539 		JBrowse link
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