tyrosinase activity - Ontology Report

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Term:	tyrosinase activity	go back to main search page
Accession:	GO:0004503	browse the term
Definition:	Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates.
Comment:	In mammals, L-DOPA can act as a cofactor for the catalyzed reaction; therefore in some resources L-DOPA is shown on both sides of the reaction. GO:0004503 describes the monooxygenation of the monophenol, L-tyrosine. For oxidation of diphenols (including L-DOPA and dopamine), consider instead the term 'catechol oxidase activity ; GO:0004097' and its children.
Synonyms:	exact_synonym:	L-tyrosine monooxygenase activity; monophenol monooxygenase activity; monophenol oxygenase
	broad_synonym:	phenol oxidase activity; phenolase activity; pyrocatechol oxidase
	related_synonym:	N-acetyl-6-hydroxytryptophan oxidase activity; catecholase; chlorogenic acid oxidase activity; chlorogenic oxidase activity; cresolase activity; dopa oxidase; monophenol monooxidase activity; monophenol oxidase activity; monophenolase activity; o-diphenol oxidase activity; o-diphenol oxidoreductase; o-diphenol:O2 oxidoreductase activity; prophenol oxidase activity; prophenoloxidase activity; tyrosine-dopa oxidase activity
	xref:	EC:1.14.18.1; MetaCyc:MONOPHENOL-MONOOXYGENASE-RXN

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Genes (2)

tyrosinase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Tyr

tyrosinase

enables

(PMID:11092760)
GO_REF:0000033
GO_REF:0000107

GO_REF:0000033 GO_REF:0000107

NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207

tyrosinase-related protein 1

enables

(PMID:21291857)
GO_REF:0000107

GO_REF:0000107

NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:95,280,982...95,299,516

Term paths to the root

Path 1
Term	Annotations
molecular_function	21102
catalytic activity	7309
oxidoreductase activity	885
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	254
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	9
tyrosinase activity	2

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