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ONTOLOGY REPORT - ANNOTATIONS

Term:N,N-dimethylaniline monooxygenase activity
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Accession:GO:0004499 term browser browse the term
Definition:Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.
Synonyms:exact_synonym: dimethylaniline monooxygenase (N-oxide-forming) activity;   methylphenyltetrahydropyridine N-monooxygenase activity
 broad_synonym: flavin-containing monooxygenase activity
 related_synonym: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity;   DMA oxidase activity;   FAD-containing monooxygenase activity;   FMO activity;   N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming);   Ziegler's enzyme;   dimethylaniline N-oxidase activity;   dimethylaniline oxidase activity;   flavin mixed function oxidase activity;   flavin monooxygenase activity;   mixed-function amine oxidase activity
 alt_id: GO:0047076
 xref: MetaCyc:1.14.13.8-RXN;   RHEA:24468;   Reactome:R-HSA-5602966 "Defective FMO3 does not N-oxidise TMA";   reactome:R-HSA-139970 "FMO3:FAD N-oxidises TMA to TMAO";   reactome:R-HSA-217255 "FMO1:FAD N-oxidises TAM"


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N,N-dimethylaniline monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmo1 flavin containing dimethylaniline monoxygenase 1 enables IDA
ISO
IEA
IBA		 (PMID:15144220)
GO_REF:0000104
(PMID:15144220), (PMID:7758472)
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:7758472 PMID:15144220 PMID:8504165 GO_REF:0000033 GO_REF:0000104, RGD:728615 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647 		JBrowse link
G Fmo13 flavin-containing monooxygenase 13 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:78,726,398...78,738,178
Ensembl chr13:78,726,398...78,738,178 		JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 enables IEA
ISO
IBA		 GO_REF:0000003
(PMID:11744609)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:11744609 GO_REF:0000003 GO_REF:0000033 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 enables IDA
IEA
IBA		 using alternative substrate L-selenomethionine, see EC 1.14.13.8
Renal location
GO_REF:0000003
GO_REF:0000033		 UniProt
GO_Central
RGD		 PMID:17173378 PMID:18775983 GO_REF:0000003 GO_REF:0000033, RGD:1626480, RGD:2325184 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
G Fmo4 flavin containing dimethylaniline monoxygenase 4 enables IEA
IBA		 GO_REF:0000003
GO_REF:0000104
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 NCBI chr13:75,154,683...75,172,874
Ensembl chr13:75,154,684...75,172,874 		JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 enables IDA
IEA
IBA		 GO_REF:0000003
GO_REF:0000033		 UniProt
GO_Central
RGD		 PMID:9711811 GO_REF:0000003 GO_REF:0000033, RGD:708323 NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693 		JBrowse link
G Fmo6 flavin containing monooxygenase 6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:75,256,617...75,288,167
Ensembl chr13:75,260,368...75,288,769 		JBrowse link
G Fmo9 flavin containing monooxygenase 9 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:78,820,080...78,841,075
Ensembl chr13:78,820,080...78,841,075 		JBrowse link
G Fmol flavin containing dimethylaniline monoxygenase like enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:78,789,759...78,804,900
Ensembl chr13:78,790,856...78,804,900 		JBrowse link
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