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ONTOLOGY REPORT - ANNOTATIONS

Term:mRNA 5'-cap (guanine-N7-)-methyltransferase activity
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Accession:GO:0004482 term browser browse the term
Definition:Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.
Synonyms:related_synonym: S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity;   S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity;   guanine-7-methyltransferase activity;   messenger RNA guanine 7-methyltransferase activity;   messenger ribonucleate guanine 7-methyltransferase activity
 xref: EC:2.1.1.56;   MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN;   Reactome:R-HSA-9684016 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs";   Reactome:R-HSA-9684017 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)";   Reactome:R-HSA-9684018 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)";   Reactome:R-HSA-9694476 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 mRNAs";   Reactome:R-HSA-9694492 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA complement (minus strand)";   Reactome:R-HSA-9694737 "nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-2 gRNA (plus strand)";   Reactome:R-HSA-9830848 "L protein acts as a cap N7 methyltransferase to modify RSV mRNAs";   reactome:R-HSA-77090 "Methylation of GMP-cap by RNA Methyltransferase"


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mRNA 5'-cap (guanine-N7-)-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnmt RNA (guanine-7-) methyltransferase enables ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:22099306), (PMID:27422871), (PMID:9790902)
GO_REF:0000002
GO_REF:0000033
GO_REF:0000003		 UniProt
RGD
InterPro
GO_Central		 PMID:9790902 PMID:22099306 PMID:27422871 GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 NCBI chr18:61,886,230...61,909,775
Ensembl chr18:61,886,292...61,909,775 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21102
    catalytic activity 7309
      catalytic activity, acting on a nucleic acid 672
        catalytic activity, acting on RNA 420
          RNA methyltransferase activity 64
            mRNA methyltransferase activity 13
              mRNA 5'-cap (guanine-N7-)-methyltransferase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 21102
    catalytic activity 7309
      transferase activity 2764
        transferase activity, transferring one-carbon groups 217
          methyltransferase activity 206
            RNA methyltransferase activity 64
              mRNA methyltransferase activity 13
                mRNA 5'-cap (guanine-N7-)-methyltransferase activity 1
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