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ONTOLOGY REPORT - ANNOTATIONS

Term:leukotriene-C4 synthase activity
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Accession:GO:0004464 term browser browse the term
Definition:Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4).
Comment:Note that this function was EC:2.5.1.37.
Synonyms:related_synonym: (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening);   (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming);   LTC(4) synthase activity;   LTC(4) synthetase activity;   LTC4 synthase activity;   LTC4 synthetase activity;   leukotriene A(4):glutathione S-leukotrienyltransferase activity;   leukotriene A4:glutathione S-leukotrienyltransferase activity;   leukotriene C(4) synthetase activity;   leukotriene C4 synthetase activity;   leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)
 xref: EC:4.4.1.20;   KEGG_REACTION:R03059;   MetaCyc:LEUKOTRIENE-C4-SYNTHASE-RXN;   RHEA:17617;   reactome:R-HSA-266050 "LTA4 is converted to LTC4 by LTC4S"


show annotations for term's descendants           Sort by:
leukotriene-C4 synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5ap arachidonate 5-lipoxygenase activating protein enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 enables ISO
ISS
IEA		 (PMID:27791009)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:27791009 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323 		JBrowse link
G Ltc4s leukotriene C4 synthase enables IDA
ISO
IBA
IEA		 (PMID:8706658), (PMID:9153254)
GO_REF:0000033
(MGI:3028458|PMID:11319240), (PMID:8706658)
GO_REF:0000104		 RGD
GO_Central
UniProt		 PMID:8706658 PMID:9153254 PMID:11319240 PMID:12767051 PMID:17194456 GO_REF:0000033 GO_REF:0000104 MGI:3028458, RGD:724432, RGD:1599839 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 enables IDA
ISO
IBA		 (PMID:23409838), (PMID:8703034), (PMID:9092565)
GO_REF:0000033		 RGD
GO_Central		 PMID:8703034 PMID:9092565 PMID:23409838 PMID:14637132 GO_REF:0000033, RGD:2302289 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 enables ISO (PMID:9278457) RGD PMID:9278457 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411 		JBrowse link
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Term Annotations click to browse term
  molecular_function 20727
    catalytic activity 6109
      lyase activity 210
        carbon-sulfur lyase activity 13
          leukotriene-C4 synthase activity 5
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