isocitrate dehydrogenase (NADP+) activity - Ontology Report

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Term:	isocitrate dehydrogenase (NADP+) activity	go back to main search page
Accession:	GO:0004450	browse the term
Definition:	Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.
Synonyms:	related_synonym:	NADP isocitric dehydrogenase activity; NADP(+)-ICDH activity; NADP(+)-IDH activity; NADP-dependent isocitrate dehydrogenase activity; NADP-dependent isocitric dehydrogenase activity; NADP-linked isocitrate dehydrogenase activity; NADP-specific isocitrate dehydrogenase activity; dual-cofactor-specific isocitrate dehydrogenase activity; isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity; isocitrate:NADP+ oxidoreductase (decarboxylating); triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity
	xref:	EC:1.1.1.42; MetaCyc:ISOCITDEH-RXN; RHEA:19629; Reactome:R-HSA-450984 "IDH2 dimer decarboxylates isocitrate"; reactome:R-HSA-389540 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+"; reactome:R-HSA-389550 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+"

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Genes (2)

isocitrate dehydrogenase (NADP+) activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Idh1

isocitrate dehydrogenase (NADP(+)) 1

enables

TAS
IDA
ISO
ISS
IEA
IBA

(PMID:10521434), (PMID:19935646), (PMID:20171178)
GO_REF:0000024
GO_REF:0000117
GO_REF:0000033
(PMID:1180875), (PMID:12031902), (PMID:18275837), (PMID:1914521)

RGD
UniProt
GO_Central

PMID:1180875 PMID:1914521 PMID:10521434 PMID:12031902 PMID:18275837 More...

GO_REF:0000024 GO_REF:0000033 GO_REF:0000117, RGD:633072, RGD:1624966

NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708

Idh2

isocitrate dehydrogenase (NADP(+)) 2

enables

IDA
IEA
ISS
ISO
IBA

GO_REF:0000116
GO_REF:0000003
GO_REF:0000024
GO_REF:0000117
GO_REF:0000002
(PMID:22416140), (PMID:23226729)
GO_REF:0000118
GO_REF:0000033
(PMID:18275837), (PMID:7323947), (PMID:8867815)

RHEA
UniProt
InterPro
RGD
TreeGrafter
GO_Central

PMID:7323947 PMID:8867815 PMID:18275837 PMID:22416140 PMID:23226729 More...

GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000116 GO_REF:0000117 GO_REF:0000118, RGD:11522739

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

Term paths to the root

Path 1
Term	Annotations
molecular_function	21010
catalytic activity	6145
oxidoreductase activity	871
oxidoreductase activity, acting on CH-OH group of donors	173
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	164
isocitrate dehydrogenase [NAD(P)+] activity	4
isocitrate dehydrogenase (NADP+) activity	2

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
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ONTOLOGY REPORT - ANNOTATIONS