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ONTOLOGY REPORT - ANNOTATIONS

Term:glutathione-disulfide reductase (NADPH) activity
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Accession:GO:0004362 term browser browse the term
Definition:Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.
Comment:Note that this function was formerly EC:1.6.4.2.
Synonyms:exact_synonym: glutathione reductase activity;   glutathione-disulfide reductase (NADP) activity;   glutathione-disulfide reductase activity;   glutathione-disulphide reductase activity
 related_synonym: GSH reductase activity;   GSSG reductase activity;   NADPH-GSSG reductase activity;   NADPH-glutathione reductase activity;   NADPH:oxidized-glutathione oxidoreductase activity;   glutathione S-reductase activity;   glutathione:NADP+ oxidoreductase activity;   oxidized glutathione reduction
 xref: EC:1.8.1.7;   MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN;   RHEA:11740;   reactome:R-HSA-3323079 "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+";   reactome:R-HSA-71682 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+"


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glutathione-disulfide reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsr glutathione-disulfide reductase enables TAS
IDA
IEA
IBA
ISO		 GO_REF:0000003
PMID:21930213
GO_REF:0000107
GO_REF:0000033
(PMID:1235912), (PMID:204065), (PMID:2139228), (PMID:7323947), (PMID:8417789)		 UniProt
Ensembl
GO_Central
RGD		 PMID:204065 PMID:1235912 PMID:2139228 PMID:7323947 PMID:8417789 More... GO_REF:0000003 GO_REF:0000033 GO_REF:0000107, RGD:632952, RGD:1625133, RGD:10047267 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Txnrd1 thioredoxin reductase 1 enables IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Txnrd2 thioredoxin reductase 2 enables IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156 		JBrowse link
G Txnrd3 thioredoxin reductase 3 enables IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 4:122,072,548...122,112,493
Ensembl chr 4:122,072,548...122,112,491 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20890
    antioxidant activity 99
      glutathione-disulfide reductase (NADPH) activity 4
Path 2
Term Annotations click to browse term
  molecular_function 20890
    catalytic activity 6118
      oxidoreductase activity 872
        oxidoreductase activity, acting on a sulfur group of donors 58
          disulfide oxidoreductase activity 43
            glutathione disulfide oxidoreductase activity 9
              glutathione-disulfide reductase (NADPH) activity 4
paths to the root