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ONTOLOGY REPORT - ANNOTATIONS


Term:fatty acid synthase activity
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Accession:GO:0004312 term browser browse the term
Definition:Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.
Synonyms:related_synonym: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
 xref: EC:2.3.1.85;   MetaCyc:FATTY-ACID-SYNTHASE-RXN;   RHEA:14993;   reactome:R-HSA-75872 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O"



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fatty acid synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fasn fatty acid synthase enables IDA
IBA
ISO
PMID:21873635
(MGI:5426758|PMID:22331133)
PMID:21569266
PMID:21389266
RGD PMID:22331133 PMID:18062843 PMID:21873635 PMID:21569266 PMID:21389266 More... MGI:5426758, RGD:2317315, RGD:13792537, RGD:10047183, RGD:10047361, RGD:2317317 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Mcat malonyl-CoA-acyl carrier protein transacylase enables ISO (PMID:12882974) RGD PMID:12882974 NCBI chr 7:114,693,612...114,705,677
Ensembl chr 7:114,693,612...114,704,542
JBrowse link
3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fasn fatty acid synthase enables IEA GO_REF:0000003
GO_REF:0000116
UniProt
RHEA
GO_REF:0000003 GO_REF:0000116 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbr4 carbonyl reductase 4 enables ISS
ISO
GO_REF:0000024
UniProtKB:Q92506 (PMID:19571038), (PMID:25203508)
UniProt
RGD
PMID:19571038 PMID:25203508 GO_REF:0000024 NCBI chr16:28,629,928...28,684,230
Ensembl chr16:28,617,224...28,645,712
JBrowse link
G Fasn fatty acid synthase enables IEA GO_REF:0000116
GO_REF:0000003
RHEA
UniProt
GO_REF:0000003 GO_REF:0000116 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
3-oxoacyl-[acyl-carrier-protein] synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fasn fatty acid synthase enables IEA GO_REF:0000003
GO_REF:0000116
UniProt
RHEA
GO_REF:0000003 GO_REF:0000116 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Oxsm 3-oxoacyl-ACP synthase, mitochondrial enables IBA
ISO
PMID:21873635
(PMID:15668256)
RGD PMID:15668256 PMID:21873635 RGD:13792537 NCBI chr15:9,210,443...9,215,852
Ensembl chr15:9,210,547...9,214,558
JBrowse link
[acyl-carrier-protein] S-acetyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fasn fatty acid synthase enables IEA GO_REF:0000116
GO_REF:0000003
RHEA
UniProt
GO_REF:0000003 GO_REF:0000116 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
[acyl-carrier-protein] S-malonyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fasn fatty acid synthase enables IMP PMID:8940200 UniProt PMID:8940200 RGD:15090840 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Mcat malonyl-CoA-acyl carrier protein transacylase enables IBA
ISO
PMID:21873635
(PMID:12882974)
RGD PMID:12882974 PMID:21873635 RGD:13792537 NCBI chr 7:114,693,612...114,705,677
Ensembl chr 7:114,693,612...114,704,542
JBrowse link
acyl-[acyl-carrier-protein] hydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Olah oleoyl-ACP hydrolase enables EXP
IDA
PMID:627544
PMID:8446599
Reactome
UniProt
PMID:627544 PMID:8446599 RGD:11059591, RGD:13524614 NCBI chr17:74,877,651...74,902,517
Ensembl chr17:74,877,655...74,902,518
JBrowse link
dodecanoyl-[acyl-carrier-protein] hydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Olah oleoyl-ACP hydrolase enables ISS
ISO
GO_REF:0000024
(PMID:26663084)
UniProt
RGD
PMID:26663084 GO_REF:0000024 NCBI chr17:74,877,651...74,902,517
Ensembl chr17:74,877,655...74,902,518
JBrowse link
fatty acid elongase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Elovl1 ELOVL fatty acid elongase 1 enables ISO
IBA
(PMID:10970790), (PMID:20166112)
PMID:21873635
RGD PMID:10970790 PMID:20166112 PMID:21873635 RGD:13792537 NCBI chr 5:131,961,478...131,965,961
Ensembl chr 5:131,961,322...131,965,958
JBrowse link
G Elovl2 ELOVL fatty acid elongase 2 enables ISO
IBA
(MGI:4943668|PMID:12371743)
PMID:21873635
(PMID:10970790), (PMID:12371743)
RGD PMID:10970790 PMID:12371743 PMID:21873635 MGI:4943668, RGD:13792537 NCBI chr17:23,544,520...23,584,855
Ensembl chr17:23,544,568...23,584,848
JBrowse link
G Elovl3 ELOVL fatty acid elongase 3 enables ISO
IBA
(PMID:10970790)
PMID:21873635
RGD PMID:10970790 PMID:21873635 RGD:13792537 NCBI chr 1:244,997,287...245,001,115
Ensembl chr 1:244,997,287...245,001,115
JBrowse link
G Elovl4 ELOVL fatty acid elongase 4 enables ISO
IBA
(MGI:3807353|PMID:18728184), (MGI:5471863|PMID:23479632)
PMID:21873635
RGD PMID:18728184 PMID:23479632 PMID:21873635 MGI:3807353 MGI:5471863, RGD:13792537 NCBI chr 8:84,702,916...84,729,466
Ensembl chr 8:84,702,362...84,729,697
JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 enables IDA
IBA
ISO
PMID:12005057
PMID:21873635
(PMID:10970790), (PMID:20427700)
RGD PMID:10970790 PMID:20427700 PMID:12005057 PMID:21873635 RGD:8554529, RGD:13792537 NCBI chr 8:78,790,799...78,857,307
Ensembl chr 8:78,790,846...78,857,284
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 enables ISO
IBA
IDA
UniProtKB:Q9VV87 (PMID:25003994), (PMID:26214738)
PMID:21873635
PMID:12005057
RGD PMID:25003994 PMID:26214738 PMID:21873635 PMID:12005057 RGD:13792537, RGD:8554529 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
JBrowse link
G Elovl7 ELOVL fatty acid elongase 7 enables ISO
IEA
IBA
(PMID:19826053)
GO_REF:0000002
PMID:21873635
RGD
InterPro
PMID:19826053 PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 2:39,789,229...39,858,579
Ensembl chr 2:39,789,250...39,856,845
JBrowse link
myristoyl-[acyl-carrier-protein] hydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fasn fatty acid synthase enables IEA GO_REF:0000116
GO_REF:0000003
RHEA
UniProt
GO_REF:0000003 GO_REF:0000116 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Olah oleoyl-ACP hydrolase enables ISO
ISS
(PMID:26663084)
GO_REF:0000024
RGD
UniProt
PMID:26663084 GO_REF:0000024 NCBI chr17:74,877,651...74,902,517
Ensembl chr17:74,877,655...74,902,518
JBrowse link
oleoyl-[acyl-carrier-protein] hydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fasn fatty acid synthase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Olah oleoyl-ACP hydrolase enables IEA GO_REF:0000116
GO_REF:0000003
RHEA
UniProt
GO_REF:0000003 GO_REF:0000116 NCBI chr17:74,877,651...74,902,517
Ensembl chr17:74,877,655...74,902,518
JBrowse link
palmitoyl-[acyl-carrier-protein] hydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fasn fatty acid synthase enables IEA GO_REF:0000116
GO_REF:0000003
RHEA
UniProt
GO_REF:0000003 GO_REF:0000116 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Olah oleoyl-ACP hydrolase enables ISS
ISO
GO_REF:0000024
(PMID:26663084)
UniProt
RGD
PMID:26663084 GO_REF:0000024 NCBI chr17:74,877,651...74,902,517
Ensembl chr17:74,877,655...74,902,518
JBrowse link

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