ONTOLOGY REPORT - ANNOTATIONS
Term: metalloendopeptidase activity
Accession: GO:0004222
browse the term
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Synonyms: narrow_synonym: metalloendoprotease activity; metalloendoproteinase activity
xref: EC:3.4.24; Reactome:R-HSA-181567 "botC LC cleaves target cell STX1"; Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25"; Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2"; Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25"; Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1"; Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1"; Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25"; Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14"; Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)"; Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2"; Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2"; Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2"; Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2"; Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1"; Reactome:R-HSA-8874122 "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)"; Reactome:R-HSA-9624272 "MMPs cleave HB-EGF"; Reactome:R-HSA-9822532 "ADAMTS13 cleaves VWF multimer"; Reactome:R-HSA-9824402 "ADAMTS13 variant does not cleave VWF multimer"; Reactome:R-HSA-9840408 "OMA1 cleaves DELE1"; Reactome:R-HSA-9840532 "OMA1 self-cleaves"; Reactome:R-HSA-9840564 "OMA1 hydrolyzes YME1L1"; Reactome:R-HSA-9844241 "ADAMTS13 cleaves VWF variant multimer"; reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR"; reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17"; reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors"; reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors"; reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13"; reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2"; reactome:R-HSA-1458433 "Collagen type I degradation by MMP14"; reactome:R-HSA-1474196 "Collagen type II degradation by MMP14"; reactome:R-HSA-1474210 "Collagen type III degradation by MMP14"; reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13"; reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11"; reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13"; reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3"; reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12"; reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2"; reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10"; reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1"; reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9"; reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13"; reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs"; reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2"; reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF"; reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides"; reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides"; reactome:R-HSA-2022141 "Prolysyl oxidase activation"; reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12"; reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9"; reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF"; reactome:R-HSA-2473584 "Collagen type III degradation by MMP15"; reactome:R-HSA-2473594 "Collagen type II degradation by MMP15"; reactome:R-HSA-2473596 "Collagen type I degradation by MMP15"; reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13"; reactome:R-HSA-2485111 "Collagen type III degradation by MMP10"; reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13"; reactome:R-HSA-2514790 "Elastin degradation by MMP14"; reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14"; reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14"; reactome:R-HSA-2533944 "Fibronectin degradation by MMP10"; reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15"; reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7"; reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15"; reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7"; reactome:R-HSA-2537499 "Gelatin degradation by MMP19"; reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1"; reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5"; reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19"; reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14"; reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13"; reactome:R-HSA-3791319 "NID1 degradation by MMP19"; reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS"; reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4"; reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS"; reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7"; reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14"; reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7"; reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)"; reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15"; reactome:R-HSA-5333671 "CLCAs self cleave"; reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding"; reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3"; reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)"; reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1"; reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2"; reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3"; reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1"; reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4"; reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3"; reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)"; reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)"; reactome:R-HSA-8940554 "MMP2 cleaves OPTC"; reactome:R-HSA-8940561 "MMP7 cleaves OPTC"; reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)"; reactome:R-HSA-8940959 "Neurolysin degrades neurotensin"; reactome:R-HSA-8942302 "MMP13 cleaves OPTC"; reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3"; reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)"; reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU"; reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1"
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Ace
angiotensin I converting enzyme
enables
ISS ISO IEA
GO_REF:0000024 (PMID:6208535), (PMID:7683654) GO_REF:0000107
UniProt RGD Ensembl
PMID:6208535 PMID:7683654
GO_REF:0000024 GO_REF:0000107
NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131
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Adam10
ADAM metallopeptidase domain 10
enables
IDA IEA ISO
GO_REF:0000002 (PMID:18676862), (PMID:19114711)
InterPro RGD
PMID:18676862 PMID:19114711 PMID:10423016
GO_REF:0000002, RGD:631800
NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:71,345,837...71,477,889
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Adam11
ADAM metallopeptidase domain 11
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr10:88,224,185...88,242,865
Ensembl chr10:87,724,234...87,741,562
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Adam12
ADAM metallopeptidase domain 12
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:198,116,968...198,443,680
Ensembl chr 1:188,686,989...189,020,667
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Adam15
ADAM metallopeptidase domain 15
enables
TAS IBA IEA
GO_REF:0000033 GO_REF:0000002
GO_Central InterPro RGD
PMID:11102971
GO_REF:0000002 GO_REF:0000033, RGD:632016
NCBI chr 2:177,052,363...177,062,879
Ensembl chr 2:174,754,633...174,765,113
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Adam17
ADAM metallopeptidase domain 17
enables
ISO IBA ISS IEA
(PMID:9034191) GO_REF:0000033 (PMID:14993236) (PMID:14625290), (PMID:15691827), (PMID:17010968), (PMID:24226769), (PMID:24337742), (PMID:36476876), (PMID:9034190), (PMID:9034191), (PMID:9774383), (PMID:9920899) GO_REF:0000024 GO_REF:0000002
RGD GO_Central UniProt InterPro
PMID:9034190 PMID:9034191 PMID:9774383 PMID:9920899 PMID:14625290 PMID:14993236 PMID:15691827 PMID:17010968 PMID:24226769 PMID:24337742 PMID:36476876 More...
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033
NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:40,872,856...40,920,639
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Adam18
ADAM metallopeptidase domain 18
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr16:74,054,974...74,127,861
Ensembl chr16:67,352,416...67,425,248
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Adam19
ADAM metallopeptidase domain 19
enables
ISO IBA
(PMID:11162584), (PMID:17112471) GO_REF:0000033
RGD GO_Central
PMID:11162584 PMID:17112471
GO_REF:0000033
NCBI chr10:30,992,713...31,084,455
Ensembl chr10:30,491,405...30,583,105
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Adam1a
ADAM metallopeptidase domain 1a
enables
IEA IBA
GO_REF:0000002 GO_REF:0000033
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr12:40,674,460...40,680,988
Ensembl chr12:35,017,315...35,020,311
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Adam1b
a disintegrin and metallopeptidase domain 1b
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr12:40,697,847...40,701,260
Ensembl chr12:35,037,343...35,041,082
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Adam2
ADAM metallopeptidase domain 2
enables
IEA IBA
GO_REF:0000002 GO_REF:0000033
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr15:44,418,191...44,459,570
Ensembl chr15:40,242,783...40,283,952
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Adam21
ADAM metallopeptidase domain 21
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr16:43,351,935...43,361,020
Ensembl chr16:36,618,860...36,628,008
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Adam22
ADAM metallopeptidase domain 22
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 4:26,670,984...26,925,843
Ensembl chr 4:25,715,990...25,964,962
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Adam23
ADAM metallopeptidase domain 23
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 9:72,356,479...72,503,545
Ensembl chr 9:64,862,878...65,006,515
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Adam24
ADAM metallopeptidase domain 24
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr16:58,281,748...58,287,735
Ensembl chr16:51,578,277...51,584,312
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Adam25
a disintegrin and metallopeptidase domain 25
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr16:58,192,236...58,196,262
Ensembl chr16:51,488,777...51,492,807
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Adam26a
a disintegrin and metallopeptidase domain 26A
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr16:55,336,354...55,340,765
Ensembl chr16:48,603,918...48,608,325
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Adam28
ADAM metallopeptidase domain 28
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr15:50,184,286...50,250,605
Ensembl chr15:42,944,467...43,840,672
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Adam30
ADAM metallopeptidase domain 30
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 2:188,440,918...188,444,358
Ensembl chr 2:185,752,072...185,755,599
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Adam32
ADAM metallopeptidase domain 32
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr16:73,805,023...73,914,787
Ensembl chr16:67,102,320...67,212,161
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Adam33
ADAM metallopeptidase domain 33
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 3:138,715,428...138,736,392
Ensembl chr 3:118,271,029...118,283,461
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Adam34
a disintegrin and metallopeptidase domain 34
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr16:55,290,008...55,294,201
Ensembl chr16:48,557,568...48,561,733
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Adam34l
a disintegrin and metalloprotease domain 34-like
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr16:55,269,522...55,274,688
Ensembl chr16:48,537,083...48,542,351
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Adam3a
ADAM metallopeptidase domain 3A
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr16:74,002,566...74,052,579
Ensembl chr16:67,299,949...67,349,968
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Adam5
ADAM metallopeptidase domain 5
enables
IEA IBA
GO_REF:0000002 GO_REF:0000033
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr16:73,925,345...74,001,354
Ensembl chr16:67,223,143...67,298,737
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Adam7
ADAM metallopeptidase domain 7
enables
IEA IBA
GO_REF:0000002 GO_REF:0000033
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr15:47,009,176...47,057,581
Ensembl chr15:42,833,796...42,882,201
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Adam8
ADAM metallopeptidase domain 8
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:204,206,206...204,218,988
Ensembl chr 1:194,770,060...194,788,801
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Adam9
ADAM metallopeptidase domain 9
enables
ISO IBA
(PMID:22480688), (PMID:9920899) GO_REF:0000033 (PMID:12054541)
RGD GO_Central
PMID:9920899 PMID:12054541 PMID:22480688
GO_REF:0000033
NCBI chr16:73,725,186...73,804,284
Ensembl chr16:67,022,655...67,100,917
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Adamdec1
ADAM-like, decysin 1
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr15:47,076,011...47,097,065
Ensembl chr15:42,900,636...42,921,712
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Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
enables
IEA IBA ISO ISS
GO_REF:0000107 GO_REF:0000033 MGI:3609982 (PMID:16061471) (PMID:11278559), (PMID:25122765) GO_REF:0000024
Ensembl GO_Central RGD UniProt
PMID:11278559 PMID:16061471 PMID:25122765
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr11:38,418,565...38,427,384
Ensembl chr11:24,931,761...24,941,103
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Adamts10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 7:15,033,859...15,063,800
Ensembl chr 7:14,331,745...14,361,620
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Adamts12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
enables
ISO IBA
(PMID:16611630), (PMID:17895370), (PMID:18485748) GO_REF:0000033
RGD GO_Central
PMID:16611630 PMID:17895370 PMID:18485748
GO_REF:0000033
NCBI chr 2:61,759,975...62,054,716
Ensembl chr 2:60,032,873...60,327,629
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Adamts13
ADAM metallopeptidase with thrombospondin type 1 motif, 13
enables
ISO IBA
(PMID:12775718), (PMID:18983500), (PMID:31439947) GO_REF:0000033
RGD GO_Central
PMID:12775718 PMID:18983500 PMID:31439947
GO_REF:0000033
NCBI chr 3:30,697,354...30,736,539
Ensembl chr 3:10,300,028...10,346,687
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Adamts14
ADAM metallopeptidase with thrombospondin type 1 motif, 14
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr20:29,685,876...29,762,685
Ensembl chr20:29,144,354...29,219,866
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Adamts15
ADAM metallopeptidase with thrombospondin type 1 motif, 15
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 8:37,566,064...37,589,446
Ensembl chr 8:29,307,865...29,331,249
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Adamts16
ADAM metallopeptidase with thrombospondin type 1 motif, 16
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:34,258,899...34,388,952
Ensembl chr 1:32,430,436...32,560,494
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Adamts17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:129,856,062...130,178,430
Ensembl chr 1:120,445,749...120,768,202
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Adamts18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr19:58,596,095...58,749,239
Ensembl chr19:41,688,617...41,839,781
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Adamts19
ADAM metallopeptidase with thrombospondin type 1 motif, 19
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr18:54,545,357...54,729,184
Ensembl chr18:52,347,428...52,530,509
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Adamts2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr10:35,422,030...35,627,483
Ensembl chr10:34,921,049...35,123,821
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Adamts20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
enables
ISO IBA
(PMID:12562771) GO_REF:0000033
RGD GO_Central
PMID:12562771
GO_REF:0000033
NCBI chr 7:127,275,538...127,407,325
Ensembl chr 7:125,397,734...125,527,777
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Adamts3
ADAM metallopeptidase with thrombospondin type 1, motif 3
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr14:18,515,249...18,721,887
Ensembl chr14:18,231,165...18,435,556
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Adamts4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
enables
IEA IBA ISO
GO_REF:0000002 GO_REF:0000033 (PMID:23684986)
InterPro GO_Central RGD
PMID:23684986
GO_REF:0000002 GO_REF:0000033
NCBI chr13:86,203,011...86,212,500
Ensembl chr13:83,670,183...83,680,065
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Adamts5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
enables
ISO IBA
(PMID:25122765), (PMID:26668318) GO_REF:0000033
RGD GO_Central
PMID:25122765 PMID:26668318
GO_REF:0000033
NCBI chr11:38,486,945...38,533,516
Ensembl chr11:25,000,637...25,047,205
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Adamts6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 2:37,155,260...37,367,077
Ensembl chr 2:35,421,510...35,633,298
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Adamts7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
enables
ISO IBA IEA
(PMID:18485748) GO_REF:0000033 GO_REF:0000002
RGD GO_Central InterPro
PMID:18485748
GO_REF:0000002 GO_REF:0000033
NCBI chr 8:99,584,529...99,624,132
Ensembl chr 8:90,704,727...90,744,328
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Adamts8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 8:37,607,001...37,626,597
Ensembl chr 8:29,349,114...29,368,404
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Adamts9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 4:126,847,726...127,019,924
Ensembl chr 4:125,291,490...125,462,929
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Adamtsl2
ADAMTS-like 2
NOT|enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 3:30,795,882...30,832,635
Ensembl chr 3:10,404,626...10,434,554
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Afg3l1
AFG3 (ATPase family gene 3)-like 1
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr19:68,417,101...68,444,260
Ensembl chr19:51,508,613...51,537,396
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Afg3l2
AFG3 like matrix AAA peptidase subunit 2
enables
ISO IBA
(PMID:19748354), (PMID:22354088), (PMID:27642048), (PMID:28396416), (PMID:29545505), (PMID:29932645), (PMID:31327635), (PMID:37917749), (PMID:38157846) GO_REF:0000033
RGD GO_Central
PMID:19748354 PMID:22354088 PMID:27642048 PMID:28396416 PMID:29545505 PMID:29932645 PMID:31327635 PMID:37917749 PMID:38157846 More...
GO_REF:0000033
NCBI chr18:63,224,163...63,269,000
Ensembl chr18:60,954,268...60,999,110
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Astl
astacin like metalloendopeptidase
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 3:135,016,444...135,032,177
Ensembl chr 3:114,563,135...114,578,868
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Atp23
ATP23 metallopeptidase and ATP synthase assembly factor homolog
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr 7:64,600,100...64,615,240
Ensembl chr 7:62,714,785...62,729,862
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Bmp1
bone morphogenetic protein 1
enables
ISO IBA
(PMID:19079247) GO_REF:0000033
RGD GO_Central
PMID:19079247
GO_REF:0000033
NCBI chr15:51,961,310...52,005,597
Ensembl chr15:45,551,603...45,595,776
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Cirop
ciliated left-right organizer metallopeptidase
enables
IEA
GO_REF:0000104
UniProt
GO_REF:0000104
NCBI chr15:32,121,021...32,128,152
Ensembl chr15:28,151,019...28,158,129
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Ece1
endothelin converting enzyme 1
enables
IEA IBA
GO_REF:0000002 GO_REF:0000033
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 5:155,361,031...155,462,723
Ensembl chr 5:150,077,644...150,179,371
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Ece2
endothelin-converting enzyme 2
enables
ISO IBA
(PMID:11718899) GO_REF:0000033
RGD GO_Central
PMID:11718899
GO_REF:0000033
NCBI chr11:93,767,559...93,782,896
Ensembl chr11:80,263,162...80,278,428
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Ecel1
endothelin converting enzyme-like 1
enables
TAS ISO IBA IEA
(PMID:10759559) GO_REF:0000033 GO_REF:0000107 GO_REF:0000002
RGD GO_Central Ensembl InterPro
PMID:10759559 PMID:12417666
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:628377
NCBI chr 9:95,267,417...95,276,508
Ensembl chr 9:87,816,718...87,826,675
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Ide
insulin degrading enzyme
enables
IMP IBA IEA ISO ISS IDA
GO_REF:0000033 GO_REF:0000107 GO_REF:0000002 (PMID:17051221), (PMID:17613531) GO_REF:0000024 atrial natriuretic peptide cleaved at the Ser25-Phe26 bond
GO_Central Ensembl InterPro RGD UniProt
PMID:17051221 PMID:17613531 PMID:15749695 PMID:15494400
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:1626704 , RGD:1626705
NCBI chr 1:244,415,495...244,516,925
Ensembl chr 1:234,995,351...235,102,440
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Kel
Kell metallo-endopeptidase (Kell blood group)
enables
ISO IBA
(PMID:15769748) GO_REF:0000033
RGD GO_Central
PMID:15769748
GO_REF:0000033
NCBI chr 4:71,534,882...71,552,297
Ensembl chr 4:70,568,243...70,585,631
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Lmln
leishmanolysin like peptidase
enables
IEA
GO_REF:0000104
UniProt
GO_REF:0000104
NCBI chr11:81,161,330...81,230,972
Ensembl chr11:67,658,152...67,724,243
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LOC103690152
disintegrin and metalloproteinase domain-containing protein 21-like
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 6:106,987,695...106,997,143
Ensembl chr 6:101,256,172...101,265,662
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Mbtps2
membrane-bound transcription factor peptidase, site 2
enables
ISO
(PMID:11163209)
RGD
PMID:11163209
NCBI chr X:41,225,956...41,290,030
Ensembl chr X:37,410,811...37,464,430
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Mep1a
meprin A subunit alpha
enables
IEA IBA
GO_REF:0000104 GO_REF:0000033
UniProt GO_Central
GO_REF:0000033 GO_REF:0000104
NCBI chr 9:24,971,901...25,001,414
Ensembl chr 9:17,474,619...17,504,147
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Mep1b
meprin A subunit beta
enables
IDA IBA IEA
GO_REF:0000033 GO_REF:0000104
GO_Central UniProt RGD
PMID:12437103
GO_REF:0000033 GO_REF:0000104, RGD:633322
NCBI chr18:12,641,041...12,667,759
Ensembl chr18:12,365,289...12,392,840
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Mipep
mitochondrial intermediate peptidase
enables
IEA IBA
GO_REF:0000002 GO_REF:0000033
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr15:39,102,301...39,227,915
Ensembl chr15:34,926,207...35,051,727
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Mme
membrane metallo-endopeptidase
enables
ISS IBA ISO IEA
GO_REF:0000024 GO_REF:0000033 (PMID:15283675), (PMID:2521388), (PMID:27588448), (PMID:6208535), (PMID:6349683) GO_REF:0000003
UniProt GO_Central RGD
PMID:2521388 PMID:6208535 PMID:6349683 PMID:15283675 PMID:27588448
GO_REF:0000003 GO_REF:0000024 GO_REF:0000033
NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:147,722,086...147,803,792
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Mmel1
membrane metallo-endopeptidase-like 1
enables
IDA IBA IEA
GO_REF:0000033 GO_REF:0000002
GO_Central InterPro RGD
PMID:11964170
GO_REF:0000002 GO_REF:0000033, RGD:2314417
NCBI chr 5:170,713,602...170,744,058
Ensembl chr 5:165,431,343...165,461,716
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Mmp1
matrix metallopeptidase 1
enables
ISO IEA
(PMID:9920899) GO_REF:0000002
RGD InterPro
PMID:9920899
GO_REF:0000002
NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097
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Mmp10
matrix metallopeptidase 10
enables
IEA IBA
GO_REF:0000002 GO_REF:0000033
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 8:12,974,707...12,982,613
Ensembl chr 8:4,689,840...4,697,748
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Mmp11
matrix metallopeptidase 11
enables
IEA IBA
GO_REF:0000002 GO_REF:0000033
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr20:12,730,284...12,739,067
Ensembl chr20:12,730,836...12,739,628
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Mmp12
matrix metallopeptidase 12
enables
IEA IBA ISO
GO_REF:0000107 GO_REF:0000033 GO_REF:0000002 (PMID:19932771), (PMID:24784232)
Ensembl GO_Central InterPro RGD
PMID:19932771 PMID:24784232
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107
NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:4,581,785...4,599,611
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Mmp13
matrix metallopeptidase 13
enables
IDA IBA ISO IEA
GO_REF:0000033 (PMID:11953314), (PMID:14702107) GO_REF:0000107 (PMID:8576151), (PMID:9065415)
GO_Central RGD Ensembl
PMID:8576151 PMID:9065415 PMID:11953314 PMID:14702107 PMID:17941091 PMID:8910479 More...
GO_REF:0000033 GO_REF:0000107, RGD:2296055 , RGD:2298541
NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:4,497,960...4,508,239
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Mmp14
matrix metallopeptidase 14
enables
ISS IBA ISO IEA
GO_REF:0000024 GO_REF:0000033 (PMID:10737763), (PMID:21572390), (PMID:24990232) (PMID:35177851), (PMID:8015608) GO_REF:0000002
UniProt GO_Central RGD InterPro
PMID:8015608 PMID:10737763 PMID:21572390 PMID:24990232 PMID:35177851
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033
NCBI chr15:31,857,824...31,867,049
Ensembl chr15:27,887,727...27,899,864
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Mmp15
matrix metallopeptidase 15
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr19:9,669,506...9,691,000
Ensembl chr19:9,663,449...9,684,943
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Mmp16
matrix metallopeptidase 16
enables
ISO IBA IEA
(PMID:27229514) GO_REF:0000033 GO_REF:0000107
RGD GO_Central Ensembl
PMID:27229514
GO_REF:0000033 GO_REF:0000107
NCBI chr 5:36,109,265...36,353,252
Ensembl chr 5:31,312,280...31,548,388
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Mmp17
matrix metallopeptidase 17
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr12:32,710,504...32,735,418
Ensembl chr12:27,074,409...27,099,316
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Mmp19
matrix metallopeptidase 19
enables
ISO
(PMID:10809722)
RGD
PMID:10809722
NCBI chr 7:1,805,732...1,814,054
Ensembl chr 7:1,221,343...1,229,555
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Mmp1b
matrix metallopeptidase 1b (interstitial collagenase)
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 8:12,882,699...12,891,125
Ensembl chr 8:4,598,391...4,606,965
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Mmp2
matrix metallopeptidase 2
enables
IEA IBA ISO
GO_REF:0000003 GO_REF:0000033 (PMID:12419962), (PMID:15212943) GO_REF:0000002
UniProt GO_Central RGD InterPro
PMID:12419962 PMID:15212943
GO_REF:0000002 GO_REF:0000003 GO_REF:0000033
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
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Mmp20
matrix metallopeptidase 20
enables
ISO IBA
(PMID:9398237) GO_REF:0000033
RGD GO_Central
PMID:9398237
GO_REF:0000033
NCBI chr 8:13,074,279...13,114,894
Ensembl chr 8:4,789,415...4,830,035
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Mmp21
matrix metallopeptidase 21
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:197,910,178...197,915,847
Ensembl chr 1:188,480,186...188,485,855
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Mmp23
matrix metallopeptidase 23
enables
ISS IBA ISO
GO_REF:0000024 GO_REF:0000033 (PMID:9988691)
UniProt GO_Central RGD
PMID:9988691
GO_REF:0000024 GO_REF:0000033
NCBI chr 5:171,521,905...171,525,007
Ensembl chr 5:166,239,644...166,242,433
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Mmp24
matrix metallopeptidase 24
enables
ISS IBA ISO IEA
GO_REF:0000024 GO_REF:0000033 (PMID:24952463) GO_REF:0000002 GO_REF:0000107
UniProt GO_Central RGD InterPro Ensembl
PMID:24952463
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr 3:164,739,226...164,783,696
Ensembl chr 3:144,279,096...144,323,572
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Mmp25
matrix metallopeptidase 25
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr10:13,164,974...13,180,503
Ensembl chr10:12,661,208...12,675,871
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Mmp27
matrix metallopeptidase 27
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 8:13,030,752...13,040,671
Ensembl chr 8:4,745,883...4,755,806
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Mmp28
matrix metallopeptidase 28
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr10:68,738,651...68,762,377
Ensembl chr10:68,241,138...68,264,866
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Mmp3
matrix metallopeptidase 3
enables
IEA IBA
GO_REF:0000002 GO_REF:0000033
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:4,640,416...4,653,961
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Mmp7
matrix metallopeptidase 7
enables
IEA IBA
GO_REF:0000002 GO_REF:0000033
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:4,848,186...4,855,902
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Mmp8
matrix metallopeptidase 8
enables
IEA IBA
GO_REF:0000002 GO_REF:0000033
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 8:13,008,873...13,018,729
Ensembl chr 8:4,724,029...4,733,520
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Mmp9
matrix metallopeptidase 9
enables
TAS IBA ISO ISS IEA
GO_REF:0000033 (PMID:12419962), (PMID:14707083), (PMID:23142597), (PMID:9291580) (PMID:16192646), (PMID:24164424), (PMID:2551898), (PMID:9789069) GO_REF:0000024 GO_REF:0000003
GO_Central RGD UniProt
PMID:2551898 PMID:9291580 PMID:9789069 PMID:12419962 PMID:14707083 PMID:16192646 PMID:23142597 PMID:24164424 PMID:12488238 More...
GO_REF:0000003 GO_REF:0000024 GO_REF:0000033, RGD:628551
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
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Nln
neurolysin
enables
IDA IBA IEA
GO_REF:0000033 GO_REF:0000002
GO_Central InterPro RGD
PMID:7836437
GO_REF:0000002 GO_REF:0000033, RGD:9831155
NCBI chr 2:36,867,436...36,966,749
Ensembl chr 2:35,134,145...35,232,914
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Nrdc
nardilysin convertase
enables
IEA
GO_REF:0000003 GO_REF:0000002
UniProt InterPro
GO_REF:0000002 GO_REF:0000003
NCBI chr 5:128,983,395...129,047,578
Ensembl chr 5:123,755,806...123,818,595
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Oma1
OMA1 zinc metallopeptidase
enables
ISO IBA IDA IEA ISS
(PMID:20038677), (PMID:25275009), (PMID:32132706), (PMID:32132707) GO_REF:0000033 (PMID:22433842), (PMID:24550258), (PMID:24719224), (PMID:33200421) GO_REF:0000107 GO_REF:0000002 GO_REF:0000024
RGD GO_Central Ensembl InterPro UniProt
PMID:20038677 PMID:22433842 PMID:24550258 PMID:24719224 PMID:25275009 PMID:32132706 PMID:32132707 PMID:33200421 PMID:33200421 More...
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:405650318
NCBI chr 5:123,312,038...123,455,540
Ensembl chr 5:118,083,728...118,136,980
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Pappa
pappalysin
enables
ISO IBA
(PMID:11513734) GO_REF:0000033
RGD GO_Central
PMID:11513734
GO_REF:0000033
NCBI chr 5:83,513,358...83,751,364
Ensembl chr 5:78,498,300...78,730,666
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Pappa2
pappalysin 2
enables
ISO IBA
(PMID:11513734) GO_REF:0000033
RGD GO_Central
PMID:11513734
GO_REF:0000033
NCBI chr13:73,407,385...73,683,699
Ensembl chr13:70,876,794...71,147,779
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Phex
phosphate regulating endopeptidase X-linked
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr X:41,422,561...41,671,226
Ensembl chr X:37,610,760...37,854,469
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Pitrm1
pitrilysin metallopeptidase 1
enables
ISO IBA
(PMID:10360838), (PMID:16849325), (PMID:19196155), (PMID:24931469) GO_REF:0000033
RGD GO_Central
PMID:10360838 PMID:16849325 PMID:19196155 PMID:24931469
GO_REF:0000033
NCBI chr17:68,705,699...68,737,350
Ensembl chr17:63,795,671...63,839,907
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Pmpca
peptidase, mitochondrial processing subunit alpha
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr 3:29,605,823...29,614,936
Ensembl chr 3:9,207,717...9,216,844
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Pmpcb
peptidase, mitochondrial processing subunit beta
enables
ISO IBA IEA IDA
(PMID:22354088) GO_REF:0000033 GO_REF:0000107 GO_REF:0000002 PMID:12433926 PMID:10942759
RGD GO_Central Ensembl InterPro
PMID:22354088 PMID:12433926 PMID:22354088 PMID:10942759
GO_REF:0000002 GO_REF:0000033 GO_REF:0000107, RGD:13463464 , RGD:14995326 , RGD:38501073
NCBI chr 4:14,189,807...14,202,584
Ensembl chr 4:13,297,559...13,310,367
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Rce1
Ras converting CAAX endopeptidase 1
enables
IEA IBA
GO_REF:0000002 GO_REF:0000033
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 1:211,328,769...211,345,944
Ensembl chr 1:201,899,358...201,902,484
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Spg7
SPG7 matrix AAA peptidase subunit, paraplegin
enables
IEA IBA ISS
GO_REF:0000002 GO_REF:0000033 GO_REF:0000024 GO_REF:0000107
InterPro GO_Central UniProt Ensembl
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr19:68,025,619...68,059,754
Ensembl chr19:51,117,057...51,150,484
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Sprtn
SprT-like N-terminal domain
enables
IEA ISO ISS
GO_REF:0000002 (PMID:27852435), (PMID:27871365), (PMID:27871366), (PMID:32649882), (PMID:36608669) GO_REF:0000107 GO_REF:0000024
InterPro RGD Ensembl UniProt
PMID:27852435 PMID:27871365 PMID:27871366 PMID:32649882 PMID:36608669
GO_REF:0000002 GO_REF:0000024 GO_REF:0000107
NCBI chr19:69,754,989...69,762,240
Ensembl chr19:52,857,866...52,864,864
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Thop1
thimet oligopeptidase 1
enables
TAS ISO IBA IEA
(PMID:10969067) GO_REF:0000033 GO_REF:0000002
RGD GO_Central InterPro
PMID:10969067 PMID:11177571
GO_REF:0000002 GO_REF:0000033, RGD:730190
NCBI chr 7:9,283,617...9,295,957
Ensembl chr 7:8,632,916...8,645,275
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Tll1
tolloid-like 1
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr16:30,275,492...30,476,673
Ensembl chr16:25,509,146...25,709,543
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Tll2
tolloid-like 2
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:249,862,050...249,977,566
Ensembl chr 1:239,915,508...240,028,120
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Trabd2b
TraB domain containing 2B
enables
ISO IBA
(PMID:22726442) GO_REF:0000033
RGD GO_Central
PMID:22726442
GO_REF:0000033
NCBI chr 5:133,178,014...133,395,740
Ensembl chr 5:127,941,114...128,143,747
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Uqcrc2
ubiquinol cytochrome c reductase core protein 2
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:175,167,894...175,199,453
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Ybey
ybeY metalloendoribonuclease
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr20:12,164,678...12,175,150
Ensembl chr20:12,165,237...12,174,713
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Yme1l1
YME1-like 1 ATPase
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr17:90,195,485...90,235,675
Ensembl chr17:85,287,554...85,326,335
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Zmpste24
zinc metallopeptidase STE24
enables
IBA ISO
GO_REF:0000033 MGI:2158363 (PMID:11399759), (PMID:12235369), (PMID:27462105)
GO_Central RGD
PMID:11399759 PMID:12235369 PMID:27462105
GO_REF:0000033
NCBI chr 5:139,912,395...139,945,532
Ensembl chr 5:134,627,229...134,660,110
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Adam10
ADAM metallopeptidase domain 10
enables
ISO IEA IBA
(PMID:28164773) GO_REF:0000107 GO_REF:0000033
RGD Ensembl GO_Central
PMID:28164773
GO_REF:0000033 GO_REF:0000107
NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:71,345,837...71,477,889
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Adam17
ADAM metallopeptidase domain 17
enables
ISO IEA
(PMID:9774383) GO_REF:0000107
RGD Ensembl
PMID:9774383
GO_REF:0000107
NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:40,872,856...40,920,639
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Adam19
ADAM metallopeptidase domain 19
enables
ISO
(PMID:17112471)
RGD
PMID:17112471
NCBI chr10:30,992,713...31,084,455
Ensembl chr10:30,491,405...30,583,105
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Adam9
ADAM metallopeptidase domain 9
enables
ISO
(PMID:12054541)
RGD
PMID:12054541
NCBI chr16:73,725,186...73,804,284
Ensembl chr16:67,022,655...67,100,917
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all