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ONTOLOGY REPORT - ANNOTATIONS


Term:cysteine-type endopeptidase activity
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Accession:GO:0004197 term browser browse the term
Definition:Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
Synonyms:exact_synonym: thiol endopeptidase activity
 narrow_synonym: caspase activity;   lysosomal cysteine-type endopeptidase;   metacaspase activity
 xref: EC:3.4.22;   EC:3.4.22.1;   EC:3.4.22.14;   EC:3.4.22.15;   EC:3.4.22.16;   EC:3.4.22.27;   EC:3.4.22.28;   EC:3.4.22.34;   EC:3.4.22.38;   EC:3.4.22.40;   EC:3.4.22.41;   EC:3.4.22.8;   MetaCyc:3.4.22.1-RXN;   MetaCyc:3.4.22.14-RXN;   MetaCyc:3.4.22.15-RXN;   MetaCyc:3.4.22.16-RXN;   MetaCyc:3.4.22.27-RXN;   MetaCyc:3.4.22.34-RXN;   MetaCyc:3.4.22.38-RXN;   MetaCyc:3.4.22.40-RXN;   MetaCyc:3.4.22.41-RXN;   Reactome:R-HSA-5357828 "RIPK1 is cleaved by CASP8";   Reactome:R-HSA-9647999 "RCE1 cleaves S-Farn proRAS proteins";   Reactome:R-HSA-9684273 "3CLp cleaves pp1a";   Reactome:R-HSA-9684309 "3CLp cleaves nsp6-11";   Reactome:R-HSA-9684321 "nsp3 cleaves nsp1-4";   Reactome:R-HSA-9684336 "nsp1-4 cleaves itself";   Reactome:R-HSA-9684340 "3CLp cleaves pp1ab";   Reactome:R-HSA-9684351 "pp1a cleaves itself";   Reactome:R-HSA-9684352 "nsp3-4 cleaves itself";   reactome:R-HSA-114252 "Cleavage of Procaspase-3 by the apoptosome";   reactome:R-HSA-114259 "Cleavage of Procaspase9 to caspase9";   reactome:R-HSA-114261 "Cleavage of Procaspase-7 by the apoptosome";   reactome:R-HSA-1236948 "Antigen processing by cathepsin S in endosoytic vesicle";   reactome:R-HSA-139898 "Caspase-8 activates BID by cleavage";   reactome:R-HSA-139952 "Caspase-8 processing in the DISC";   reactome:R-HSA-1678920 "TLR processing at low pH";   reactome:R-HSA-1678981 "TLR9 processing at neutral pH";   reactome:R-HSA-201595 "Caspase-mediated cleavage of plakophilin-1";   reactome:R-HSA-201603 "Caspase-mediated cleavage of PKC theta";   reactome:R-HSA-201608 "Caspase-mediated cleavage of alpha adducin";   reactome:R-HSA-201611 "Caspase-mediated cleavage of Rock-1";   reactome:R-HSA-201622 "Caspase-mediated cleavage of gelsolin";   reactome:R-HSA-201628 "Caspase-mediated cleavage of vimentin at DSVD (85)";   reactome:R-HSA-201629 "Caspase-mediated cleavage of Tau";   reactome:R-HSA-201630 "Caspase-mediated cleavage of Acinus";   reactome:R-HSA-201631 "Caspase-mediated cleavage of Desmoglein 3";   reactome:R-HSA-201634 "Caspase-mediated cleavage of FADK 1";   reactome:R-HSA-201636 "Caspase-mediated cleavage of Desmoplakin";   reactome:R-HSA-201637 "Caspase-mediated cleavage of plectin-1";   reactome:R-HSA-201639 "Caspase-mediated cleavage of GAS2";   reactome:R-HSA-201640 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha";   reactome:R-HSA-2028692 "Cleavage of p-STK4 (p-MST1) by caspase 3";   reactome:R-HSA-2028697 "Cleavage of p-STK3 (p-MST2) by caspase 3";   reactome:R-HSA-202917 "Caspase-mediated cleavage of Desmoglein 1";   reactome:R-HSA-202939 "Caspase-mediated cleavage of E-Cadherin";   reactome:R-HSA-202947 "Caspase mediated cleavage of APC";   reactome:R-HSA-202960 "Caspase mediated cleavage of C-IAP1";   reactome:R-HSA-202966 "Caspase mediated cleavage of HIP-55";   reactome:R-HSA-202967 "Caspase mediated cleavage of alpha-II-Fodrin";   reactome:R-HSA-202969 "Caspase mediated cleavage of beta-catenin";   reactome:R-HSA-211186 "Cleavage of DFF45 (224) by caspase-3";   reactome:R-HSA-211190 "Caspase 3-mediated cleavage of DFF45 (117)";   reactome:R-HSA-211651 "Cleavage of PAK-2 at 212";   reactome:R-HSA-212552 "Caspase 3-mediated cleavage of PKC delta";   reactome:R-HSA-2130336 "Initial proteolyis of Ii by aspartic proteases to lip22";   reactome:R-HSA-2130349 "Generation of CLIP from lip10";   reactome:R-HSA-2130504 "Cleavage of lip22 to lip10";   reactome:R-HSA-2130706 "MHC class II antigen processing";   reactome:R-HSA-2562564 "Caspase-8 processing within TLR4 complex";   reactome:R-HSA-264865 "Caspase-mediated cleavage of Lamin A";   reactome:R-HSA-264871 "Caspase-mediated cleavage of Lamin B1";   reactome:R-HSA-3465448 "Caspase-8 and FLIP(L) processing at DISC";   reactome:R-HSA-350158 "LGMN degrades GC";   reactome:R-HSA-350318 "Caspase-mediated cleavage of vimentin at TNLD (429)";   reactome:R-HSA-350319 "Caspase mediated cleavage of vimentin at IDVD (259)";   reactome:R-HSA-350651 "Caspase-mediated cleavage of MASK";   reactome:R-HSA-351849 "Caspase-mediated cleavage of Etk";   reactome:R-HSA-351871 "Caspase-mediated cleavage of Z0-2";   reactome:R-HSA-351876 "Caspase-mediated cleavage of occludin";   reactome:R-HSA-351877 "Caspase-mediated cleavage of Desmoglein 2";   reactome:R-HSA-351894 "Caspase mediated cleavage of BAP31";   reactome:R-HSA-351901 "Caspase-mediated cleavage of MST3";   reactome:R-HSA-351913 "Caspase-mediated cleavage of TJP1";   reactome:R-HSA-351936 "Caspase-mediated cleavage of claspin";   reactome:R-HSA-352268 "Cleavage of Satb1";   reactome:R-HSA-418845 "Activation of caspase-3";   reactome:R-HSA-418846 "Caspase cleavage of UNC5A";   reactome:R-HSA-418852 "Caspase cleavage of UNC5B";   reactome:R-HSA-448703 "Interleukin-1 family precursors are cleaved by caspase-1";   reactome:R-HSA-5634228 "TRAF1 is cleaved by caspases";   reactome:R-HSA-5660663 "Caspase-8 cleaves IL1B precursor";   reactome:R-HSA-5681987 "LC3 is cleaved by ATG4";   reactome:R-HSA-5682377 "LC3 de-lipidation by ATG4";   reactome:R-HSA-6814387 "CASP14 cleaves filaggrin";   reactome:R-HSA-9012556 "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37";   reactome:R-HSA-9013895 "Caspase-8 processing within TLR3 complex";   reactome:R-HSA-933532 "Processing of caspases";   reactome:R-HSA-9603534 "Unknown caspase cleaves NTRK3"


show annotations for term's descendants           Sort by:
 
cysteine-type endopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG4A autophagy related 4A cysteine peptidase IEA InterPro GO_REF:0000002 NCBI chr  X:88,545,924...88,633,328
Ensembl chr  X:88,545,924...88,633,321
JBrowse link
G ATG4B autophagy related 4B cysteine peptidase IEA InterPro GO_REF:0000002 NCBI chr15:140,223,903...140,245,590
Ensembl chr15:140,223,903...140,249,851
JBrowse link
G ATG4C autophagy related 4C cysteine peptidase IEA InterPro GO_REF:0000002 NCBI chr 6:149,560,318...149,691,959
Ensembl chr 6:149,557,730...149,691,927
JBrowse link
G BLMH bleomycin hydrolase IEA UniProt GO_REF:0000003 NCBI chr12:46,342,502...46,393,642
Ensembl chr12:46,342,501...46,393,484
JBrowse link
G CASP1 caspase 1, apoptosis-related cysteine peptidase IEA
ISS
IBA
(PMID:21873635) InterPro
UniProt
Ensembl
GO_Central
PMID:21873635 GO_REF:0000002, GO_REF:0000024, GO_REF:0000107 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
JBrowse link
G CASP10 caspase 10 ISO (PMID:16920334) UniProtKB PMID:16920334 NCBI chr15:104,858,082...104,895,941
Ensembl chr15:104,858,100...104,894,933
JBrowse link
G CASP2 caspase 2 ISO (PMID:10980123), (PMID:21726810), (PMID:9044836) UniProtKB PMID:9044836, PMID:10980123, PMID:21726810 NCBI chr18:6,946,432...6,966,088
Ensembl chr18:6,902,542...6,966,092
JBrowse link
G CASP3 caspase 3 IEA InterPro GO_REF:0000002 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP7 caspase 7 IEA InterPro GO_REF:0000002 NCBI chr14:124,017,776...124,050,369
Ensembl chr14:124,018,568...124,050,366
JBrowse link
G CASP8 caspase 8 IEA InterPro GO_REF:0000002 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470
JBrowse link
G CASP9 caspase 9 IEA InterPro GO_REF:0000002 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,515...74,730,092
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator IEA InterPro GO_REF:0000002 NCBI chr15:104,780,744...104,835,631
Ensembl chr15:104,781,615...104,844,921
JBrowse link
G CTSB cathepsin B IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000003 NCBI chr14:15,014,139...15,035,081
Ensembl chr14:15,011,711...15,034,737
JBrowse link
G CTSC cathepsin C IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:21,726,628...21,761,796
Ensembl chr 9:21,722,035...21,761,473
JBrowse link
G CTSH cathepsin H ISS
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr 7:48,084,882...48,106,072
Ensembl chr 7:48,083,569...48,106,041
JBrowse link
G CTSL cathepsin L IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:27,668,523...27,674,705
Ensembl chr10:27,668,264...27,674,618
JBrowse link
G CTSO cathepsin O IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:44,727,626...44,765,363
Ensembl chr 8:44,728,792...44,765,041
JBrowse link
G CTSS cathepsin S IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:98,415,273...98,442,952
Ensembl chr 4:98,390,250...98,442,936
JBrowse link
G CTSV cathepsin V ISS
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr10:25,202,360...25,208,058
Ensembl chr10:25,202,388...25,209,235
JBrowse link
G CTSW cathepsin W IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:6,446,105...6,450,357
Ensembl chr 2:6,446,105...6,450,360
JBrowse link
G CTSZ cathepsin Z IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:59,141,497...59,149,377
Ensembl chr17:59,141,501...59,149,298
JBrowse link
G ESPL1 extra spindle pole bodies like 1, separase IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr 5:18,486,969...18,509,913
Ensembl chr 5:18,487,052...18,509,913
JBrowse link
G LGMN legumain IDA
IEA
IBA
IMP
(PMID:9065484)
(PMID:21873635)
ARUK-UCL
UniProt
GO_Central
PMID:9065484, PMID:21873635 GO_REF:0000003 NCBI chr 7:114,176,217...114,210,096
Ensembl chr 7:114,173,693...114,217,103
JBrowse link
G LOC100522887 caspase-13 IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr 9:35,167,567...35,185,791 JBrowse link
G LOC100625207 probable ubiquitin carboxyl-terminal hydrolase FAF-X IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  Y:9,374,888...9,552,316 JBrowse link
G LOC100626328 ubiquitin carboxyl-terminal hydrolase 17-like protein 6 IBA (PMID:21873635) GO_Central PMID:21873635
G LOC102162178 probable ubiquitin carboxyl-terminal hydrolase FAF-X IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  Y:9,565,582...9,614,075 JBrowse link
G MALT1 MALT1 paracaspase IEA InterPro GO_REF:0000002 NCBI chr 1:162,076,933...162,144,915
Ensembl chr 1:162,076,951...162,144,880
JBrowse link
G RCE1 Ras converting CAAX endopeptidase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:5,587,853...5,595,408
Ensembl chr 2:5,588,538...5,593,142
JBrowse link
G SFRP1 secreted frizzled related protein 1 IEA Ensembl GO_REF:0000107 NCBI chr17:10,436,414...10,489,773
Ensembl chr17:10,436,426...10,489,748
JBrowse link
G UCHL1 ubiquitin C-terminal hydrolase L1 IEA Ensembl GO_REF:0000107 NCBI chr 8:32,353,766...32,367,288
Ensembl chr 8:32,353,246...32,367,323
JBrowse link
G USP1 ubiquitin specific peptidase 1 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr 6:149,971,471...149,985,946
Ensembl chr 6:149,970,915...149,985,506
JBrowse link
G USP10 ubiquitin specific peptidase 10 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:3,977,235...4,043,539
Ensembl chr 6:3,977,229...4,043,534
JBrowse link
G USP12 ubiquitin specific peptidase 12 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:4,612,274...4,689,791
Ensembl chr11:4,612,277...4,689,432
JBrowse link
G USP13 ubiquitin specific peptidase 13 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:117,700,080...117,826,951
Ensembl chr13:117,700,119...117,826,946
JBrowse link
G USP15 ubiquitin specific peptidase 15 IEA Ensembl GO_REF:0000107 NCBI chr 5:26,964,380...27,082,549
Ensembl chr 5:26,964,510...27,097,458
JBrowse link
G USP16 ubiquitin specific peptidase 16 IEA UniProt GO_REF:0000104 NCBI chr13:192,376,850...192,406,474
Ensembl chr13:192,376,881...192,406,474
JBrowse link
G USP18 ubiquitin specific peptidase 18 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:70,183,321...70,227,990
Ensembl chr 5:70,183,308...70,227,990
JBrowse link
G USP20 ubiquitin specific peptidase 20 IEA Ensembl GO_REF:0000107 NCBI chr 1:269,995,532...270,037,499
Ensembl chr 1:269,995,520...270,086,780
JBrowse link
G USP22 ubiquitin specific peptidase 22 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:61,273,939...61,308,381
Ensembl chr12:61,271,641...61,308,270
JBrowse link
G USP24 ubiquitin specific peptidase 24 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:157,220,521...157,385,329
Ensembl chr 6:157,220,602...157,385,055
JBrowse link
G USP25 ubiquitin specific peptidase 25 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:180,571,019...180,708,966
Ensembl chr13:180,570,969...180,714,075
JBrowse link
G USP26 ubiquitin specific peptidase 26 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:109,092,622...109,095,548 JBrowse link
G USP28 ubiquitin specific peptidase 28 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:41,417,560...41,481,044
Ensembl chr 9:41,417,559...41,480,985
JBrowse link
G USP30 ubiquitin specific peptidase 30 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:41,765,220...41,818,937
Ensembl chr14:41,765,230...41,818,890
JBrowse link
G USP33 ubiquitin specific peptidase 33 IEA Ensembl GO_REF:0000107 NCBI chr 6:135,524,372...135,589,742
Ensembl chr 6:135,524,394...135,589,737
JBrowse link
G USP34 ubiquitin specific peptidase 34 IEA Ensembl GO_REF:0000107 NCBI chr 3:80,330,896...80,589,514
Ensembl chr 3:80,370,691...80,587,761
JBrowse link
G USP35 ubiquitin specific peptidase 35 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:12,586,028...12,662,958
Ensembl chr 9:12,585,955...12,662,957
JBrowse link
G USP37 ubiquitin specific peptidase 37 ISS
IBA
IEA
(PMID:21873635) UniProt
GO_Central
Ensembl
PMID:21873635 GO_REF:0000024, GO_REF:0000107 NCBI chr15:120,492,552...120,590,230
Ensembl chr15:120,492,888...120,590,214
JBrowse link
G USP38 ubiquitin specific peptidase 38 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:84,567,476...84,601,044
Ensembl chr 8:84,567,618...84,601,224
JBrowse link
G USP40 ubiquitin specific peptidase 40 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:133,870,831...133,952,863
Ensembl chr15:133,870,834...133,952,863
JBrowse link
G USP42 ubiquitin specific peptidase 42 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:5,002,406...5,048,327
Ensembl chr 3:5,002,431...5,048,284
JBrowse link
G USP46 ubiquitin specific peptidase 46 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:39,518,155...39,581,990
Ensembl chr 8:39,517,512...39,581,727
JBrowse link
G USP47 ubiquitin specific peptidase 47 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:47,449,162...47,583,893
Ensembl chr 2:47,448,122...47,582,814
JBrowse link
G USP48 ubiquitin specific peptidase 48 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:79,744,928...79,810,241
Ensembl chr 6:79,744,932...79,810,672
JBrowse link
G USP49 ubiquitin specific peptidase 49 IEA Ensembl GO_REF:0000107 NCBI chr 7:36,978,291...37,054,027
Ensembl chr 7:36,981,383...37,030,151
JBrowse link
G USP5 ubiquitin specific peptidase 5 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:63,843,742...63,858,835
Ensembl chr 5:63,843,742...63,858,751
JBrowse link
G USP7 ubiquitin specific peptidase 7 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:33,754,357...33,810,480
Ensembl chr 3:33,775,829...33,810,466
JBrowse link
G USP9X ubiquitin specific peptidase 9 X-linked IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:36,736,049...36,888,702
Ensembl chr  X:36,760,819...36,885,275
JBrowse link
calcium-dependent cysteine-type endopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADGB androglobin IEA InterPro GO_REF:0000002 NCBI chr 1:18,870,880...19,030,983
Ensembl chr 1:18,870,875...19,097,892
JBrowse link
G CAPN1 calpain 1 IDA
IEA
ISS
(PMID:15640140) CAFA
Ensembl
InterPro
UniProt
PMID:15640140 GO_REF:0000002, GO_REF:0000024, GO_REF:0000107 NCBI chr 2:6,997,513...7,024,410
Ensembl chr 2:6,997,516...7,081,432
JBrowse link
G CAPN10 calpain 10 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr15:139,557,643...139,568,764
Ensembl chr15:139,557,666...139,570,181
JBrowse link
G CAPN11 calpain 11 NOT IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr 7:39,168,991...39,191,934
Ensembl chr 7:39,168,677...39,191,396
JBrowse link
G CAPN12 calpain 12 NOT IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:47,565,917...47,579,278
Ensembl chr 6:47,565,044...47,578,795
JBrowse link
G CAPN13 calpain 13 IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr 3:108,530,743...108,621,119
Ensembl chr 3:108,531,147...108,620,616
JBrowse link
G CAPN14 calpain 14 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:108,152,053...108,191,391
Ensembl chr 3:108,151,519...108,190,047
JBrowse link
G CAPN15 calpain 15 IEA InterPro GO_REF:0000002 NCBI chr 3:41,190,626...41,208,657
Ensembl chr 3:41,190,830...41,208,624
JBrowse link
G CAPN2 calpain 2 NOT
contributes_to
ISS
IEA
IBA
ISO
(PMID:21873635) UniProt
Ensembl
GO_Central
RGD
InterPro
PMID:7982961, PMID:21873635 GO_REF:0000002, GO_REF:0000024, GO_REF:0000107, RGD:634695 NCBI chr10:19,758,824...19,820,241
Ensembl chr10:19,758,762...19,851,989
JBrowse link
G CAPN3 calpain 3 IEA
IBA
ISS
(PMID:21873635) InterPro
Ensembl
GO_Central
UniProt
PMID:21873635 GO_REF:0000002, GO_REF:0000024, GO_REF:0000107 NCBI chr 1:128,960,117...129,013,508
Ensembl chr 1:128,960,121...129,013,547
JBrowse link
G CAPN5 calpain 5 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:11,194,302...11,246,713
Ensembl chr 9:11,207,835...11,246,711
JBrowse link
G CAPN6 calpain 6 NOT IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:91,258,696...91,288,128
Ensembl chr  X:91,258,712...91,288,020
JBrowse link
G CAPN7 calpain 7 IEA InterPro GO_REF:0000002 NCBI chr13:2,452,385...2,503,575
Ensembl chr13:2,452,224...2,504,573
JBrowse link
G CAPN8 calpain 8 NOT IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr10:19,622,274...19,732,106
Ensembl chr10:19,624,172...19,731,989
JBrowse link
G CAPN9 calpain 9 NOT IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr14:59,581,999...59,623,553
Ensembl chr14:59,582,046...59,623,376
JBrowse link
G CAPNS1 calpain small subunit 1 contributes_to ISO
IEA
RGD
Ensembl
PMID:7982961 GO_REF:0000107, RGD:634695 NCBI chr 6:45,511,410...45,518,610
Ensembl chr 6:45,511,339...45,520,859
JBrowse link
G RAB32 RAB32, member RAS oncogene family IEA InterPro GO_REF:0000002 NCBI chr 1:19,076,301...19,097,647
Ensembl chr 1:18,870,875...19,097,892
JBrowse link
cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP1 caspase 1, apoptosis-related cysteine peptidase NOT IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
JBrowse link
G CASP10 caspase 10 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:104,858,082...104,895,941
Ensembl chr15:104,858,100...104,894,933
JBrowse link
G CASP2 caspase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:6,946,432...6,966,088
Ensembl chr18:6,902,542...6,966,092
JBrowse link
G CASP3 caspase 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP6 caspase 6 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,483,392...112,540,550
JBrowse link
G CASP7 caspase 7 IEA Ensembl GO_REF:0000107 NCBI chr14:124,017,776...124,050,369
Ensembl chr14:124,018,568...124,050,366
JBrowse link
G CASP8 caspase 8 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470
JBrowse link
G CASP9 caspase 9 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,515...74,730,092
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:104,780,744...104,835,631
Ensembl chr15:104,781,615...104,844,921
JBrowse link
G CLCN1 chloride voltage-gated channel 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:6,902,540...6,941,530
Ensembl chr18:6,902,542...6,966,092
JBrowse link
G LGALS13 lectin, galactoside-binding, soluble, 13 IEA Ensembl GO_REF:0000107 NCBI chr 6:48,205,158...48,209,859
Ensembl chr 6:48,205,158...48,209,867
JBrowse link
G LOC100522011 apoptosis-associated speck-like protein containing a CARD IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,179...17,307,512
JBrowse link
G LOC100522887 caspase-13 NOT IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:35,167,567...35,185,791 JBrowse link
cysteine-type endopeptidase activity involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP1 caspase 1, apoptosis-related cysteine peptidase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
JBrowse link
G CASP10 caspase 10 IBA
IEA
(PMID:21873635) GO_Central
InterPro
Ensembl
PMID:21873635 GO_REF:0000002, GO_REF:0000107 NCBI chr15:104,858,082...104,895,941
Ensembl chr15:104,858,100...104,894,933
JBrowse link
G CASP2 caspase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:6,946,432...6,966,088
Ensembl chr18:6,902,542...6,966,092
JBrowse link
G CASP3 caspase 3 ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP8 caspase 8 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470
JBrowse link
G CASP9 caspase 9 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,515...74,730,092
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:104,780,744...104,835,631
Ensembl chr15:104,781,615...104,844,921
JBrowse link
G CLCN1 chloride voltage-gated channel 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:6,902,540...6,941,530
Ensembl chr18:6,902,542...6,966,092
JBrowse link
G LOC100522887 caspase-13 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:35,167,567...35,185,791 JBrowse link
cysteine-type endopeptidase activity involved in execution phase of apoptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP1 caspase 1, apoptosis-related cysteine peptidase NOT IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
JBrowse link
G CASP10 caspase 10 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:104,858,082...104,895,941
Ensembl chr15:104,858,100...104,894,933
JBrowse link
G CASP14 caspase 14 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:62,522,294...62,531,594
Ensembl chr 2:62,521,997...62,531,539
JBrowse link
G CASP2 caspase 2 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr18:6,946,432...6,966,088
Ensembl chr18:6,902,542...6,966,092
JBrowse link
G CASP3 caspase 3 IEA Ensembl GO_REF:0000107 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP6 caspase 6 IEA
IBA
(PMID:21873635) InterPro
Ensembl
GO_Central
PMID:21873635 GO_REF:0000002, GO_REF:0000107 NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,483,392...112,540,550
JBrowse link
G CASP7 caspase 7 ISO (PMID:22253444) CAFA PMID:22253444 NCBI chr14:124,017,776...124,050,369
Ensembl chr14:124,018,568...124,050,366
JBrowse link
G CASP8 caspase 8 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470
JBrowse link
G CASP9 caspase 9 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,515...74,730,092
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:104,780,744...104,835,631
Ensembl chr15:104,781,615...104,844,921
JBrowse link
G CLCN1 chloride voltage-gated channel 1 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr18:6,902,540...6,941,530
Ensembl chr18:6,902,542...6,966,092
JBrowse link
G LOC100522887 caspase-13 NOT IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:35,167,567...35,185,791 JBrowse link
G LOC100627836 uncharacterized LOC100627836 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:39,066,931...39,073,599 JBrowse link
G LOC641352 caspase-15 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:24,046,127...24,068,431 JBrowse link
G PLA2G12A phospholipase A2 group XIIA IEA InterPro GO_REF:0000002 NCBI chr 8:112,483,322...112,512,520 JBrowse link
GPI-anchor transamidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIGK phosphatidylinositol glycan anchor biosynthesis class K ISS
IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000024, GO_REF:0000104 NCBI chr 6:136,057,996...136,175,236
Ensembl chr 6:136,057,985...136,180,637
JBrowse link
SUMO-specific endopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SENP2 SUMO specific peptidase 2 IEA Ensembl GO_REF:0000107 NCBI chr13:123,429,915...123,469,913
Ensembl chr13:123,429,995...123,471,929
JBrowse link
G SENP6 SUMO specific peptidase 6 IEA Ensembl GO_REF:0000107 NCBI chr 1:90,166,997...90,299,981
Ensembl chr 1:90,167,944...90,299,981
JBrowse link
G SENP7 SUMO specific peptidase 7 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:157,521,778...157,672,818
Ensembl chr13:157,521,781...157,672,818
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17442
    catalytic activity 5460
      hydrolase activity 2354
        peptidase activity 606
          endopeptidase activity 415
            cysteine-type endopeptidase activity 88
              GPI-anchor transamidase activity 1
              calcium-dependent cysteine-type endopeptidase activity 17
              cysteine-type endopeptidase activity involved in apoptotic process + 17
              ubiquitin-like protein-specific endopeptidase activity + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.