Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:metallocarboxypeptidase activity
go back to main search page
Accession:GO:0004181 term browser browse the term
Definition:Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Synonyms:xref: EC:3.4.17;   reactome:R-HSA-2022378 "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)";   reactome:R-HSA-2022379 "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)";   reactome:R-HSA-2028294 "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)";   reactome:R-HSA-8852809 "CPN, CPB2 cleave C3a, C5a";   reactome:R-HSA-8866105 "CCPs deglutamylate tubulin";   reactome:R-HSA-8955712 "TTCP hydrolyzes the terminal L-Tyr residue from alpha-tubulin";   reactome:R-HSA-9023159 "Carboxypeptidase E cleaves C-peptide (Insulin(57-89)) to yield C-peptide (Insulin(57-87))";   reactome:R-HSA-9023163 "Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54)"


show annotations for term's descendants       view all columns           Sort by:
 
metallocarboxypeptidase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace2 angiotensin I converting enzyme 2 JBrowse link X 32,050,734 32,095,860 RGD:1624291
G Aebp1 AE binding protein 1 JBrowse link 14 86,101,253 86,111,323 RGD:1600115
RGD:13792537
G Agbl1 ATP/GTP binding protein-like 1 JBrowse link 1 137,798,862 138,711,126 RGD:1624291
G Agbl2 ATP/GTP binding protein-like 2 JBrowse link 3 79,622,791 79,647,402 RGD:1624291
G Agbl3 ATP/GTP binding protein-like 3 JBrowse link 4 62,293,158 62,377,740 RGD:1624291
G Agbl4 ATP/GTP binding protein-like 4 JBrowse link 5
5
130,742,297
130,286,393
131,656,581
130,305,884
RGD:1624291
RGD:1600115
G Agbl5 ATP/GTP binding protein-like 5 JBrowse link 6 26,837,299 26,857,234 RGD:1600115
RGD:1624291
G Agtpbp1 ATP/GTP binding protein 1 JBrowse link 17 5,510,009 5,614,416 RGD:1600115
G Cpa1 carboxypeptidase A1 JBrowse link 4 57,952,982 57,959,109 RGD:13792537
G Cpa2 carboxypeptidase A2 JBrowse link 4 57,855,416 57,879,239 RGD:1600115
RGD:13792537
RGD:1624291
G Cpa3 carboxypeptidase A3 JBrowse link 2 105,016,798 105,047,989 RGD:1600115
RGD:13792537
G Cpa4 carboxypeptidase A4 JBrowse link 4 57,883,849 57,907,826 RGD:13792537
G Cpa5 carboxypeptidase A5 JBrowse link 4 57,925,334 57,945,069 RGD:13792537
G Cpa6 carboxypeptidase A6 JBrowse link 5 8,215,443 8,574,655 RGD:13792537
G Cpb1 carboxypeptidase B1 JBrowse link 2 105,059,293 105,089,682 RGD:1600115
RGD:13792537
G Cpb2 carboxypeptidase B2 JBrowse link 15 57,290,849 57,339,762 RGD:13792537
G Cpd carboxypeptidase D JBrowse link 10 63,325,764 63,389,811 RGD:1600115
RGD:13792537
G Cpe carboxypeptidase E JBrowse link 16 26,906,716 27,014,811 RGD:13792537
RGD:1600115
G Cpm carboxypeptidase M JBrowse link 7 60,654,350 60,714,620 RGD:13792537
G Cpn1 carboxypeptidase N subunit 1 JBrowse link 1 263,733,887 263,762,758 RGD:13792537
G Cpo carboxypeptidase O JBrowse link 9 70,603,023 70,641,290 RGD:1624291
G Cpxm1 carboxypeptidase X (M14 family), member 1 JBrowse link 3 122,913,886 122,920,684 RGD:13792537
G Cpxm2 carboxypeptidase X (M14 family), member 2 JBrowse link 1 204,048,785 204,161,090 RGD:13792537
G Cpz carboxypeptidase Z JBrowse link 14 80,402,946 80,426,203 RGD:1600115
RGD:13792537
G Folh1 folate hydrolase 1 JBrowse link 1 150,323,768 150,395,415 RGD:1600115
RGD:1624291
G Vash1 vasohibin 1 JBrowse link 6 110,624,377 110,640,942 RGD:1624291
G Vash2 vasohibin 2 JBrowse link 13 109,521,190 109,552,607 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19528
    catalytic activity 6039
      hydrolase activity 2608
        peptidase activity 693
          peptidase activity, acting on L-amino acid peptides 663
            exopeptidase activity 104
              carboxypeptidase activity 44
                metallocarboxypeptidase activity 27
                  glutathione S-conjugate carboxypeptidase activity 0
                  murein tripeptide carboxypeptidase activity 0
                  zinc D-Ala-D-Ala carboxypeptidase activity 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.