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ONTOLOGY REPORT - ANNOTATIONS

Term:cytochrome-c oxidase activity
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Accession:GO:0004129 term browser browse the term
Definition:Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Comment:The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment.
Synonyms:narrow_synonym: aa3-type cytochrome c oxidase;   ba3-type cytochrome c oxidase;   caa3-type cytochrome c oxidase;   cbb3-type cytochrome c oxidase;   cytochrome a3 activity;   cytochrome aa3 activity;   indophenol oxidase;   indophenolase
 related_synonym: complex IV (mitochondrial electron transport) activity;   cytochrome oxidase activity;   warburg's respiratory enzyme activity
 xref: EC:7.1.1.9;   MetaCyc:CYTOCHROME-C-OXIDASE-RXN;   RHEA:11436;   reactome:R-HSA-163214 "Electron transfer from reduced cytochrome c to molecular oxygen"

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cytochrome-c oxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COX1 cytochrome c oxidase subunit I enables IEA UniProt
TreeGrafter
Ensembl
InterPro
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 NCBI chr MT:5,320...6,861 JBrowse link
G COX2 cytochrome c oxidase subunit II enables IEA Ensembl
TreeGrafter
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr MT:7,007...7,690 JBrowse link
G COX3 cytochrome c oxidase subunit III enables IEA UniProt
InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000118 NCBI chr MT:8,604...9,387 JBrowse link
G LOC101710326 surfeit locus protein 1 enables ISO (PMID:12566387)
(PMID:23838831)		 MGI
UniProt		 PMID:12566387 PMID:23838831 NCBI chrNW_004624760:1,815,215...1,819,014
Ensembl chrNW_004624760:1,815,224...1,818,991 		JBrowse link
G LOC101714003 cytochrome c oxidase subunit 4 isoform 2, mitochondrial enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624741:852,104...863,660
Ensembl chrNW_004624741:850,551...861,313 		JBrowse link
G LOC101714403 cytochrome c oxidase subunit 5A, mitochondrial ISO RGD PMID:7601105 RGD:727762 NCBI chrNW_004624894:107,464...120,365
Ensembl chrNW_004624894:107,034...121,020 		JBrowse link
G LOC101715151 cytochrome c oxidase subunit 7A1, mitochondrial contributes_to ISO (PMID:22119795), (PMID:22869013) UniProt PMID:22119795 PMID:22869013 NCBI chrNW_004624794:10,392,028...10,393,728
Ensembl chrNW_004624794:10,392,028...10,393,670 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18442
    electron transfer activity 57
      cytochrome-c oxidase activity 7
Path 2
Term Annotations click to browse term
  molecular_function 18442
    transporter activity 1152
      transmembrane transporter activity 1051
        active transmembrane transporter activity 386
          primary active transmembrane transporter activity 134
            oxidoreduction-driven active transmembrane transporter activity 30
              cytochrome-c oxidase activity 7
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