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ONTOLOGY REPORT - ANNOTATIONS

Term:cytochrome-c oxidase activity
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Accession:GO:0004129 term browser browse the term
Definition:Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Comment:The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment.
Synonyms:narrow_synonym: aa3-type cytochrome c oxidase;   ba3-type cytochrome c oxidase;   caa3-type cytochrome c oxidase;   cbb3-type cytochrome c oxidase;   cytochrome a3 activity;   cytochrome aa3 activity;   indophenol oxidase;   indophenolase
 related_synonym: complex IV (mitochondrial electron transport) activity;   cytochrome oxidase activity;   warburg's respiratory enzyme activity
 xref: EC:7.1.1.9;   MetaCyc:CYTOCHROME-C-OXIDASE-RXN;   RHEA:11436;   reactome:R-HSA-163214 "Electron transfer from reduced cytochrome c to molecular oxygen"


show annotations for term's descendants           Sort by:
cytochrome-c oxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COX4I1 cytochrome c oxidase subunit 4I1 enables TAS (PMID:2157630) PINC PMID:2157630 NCBI chr16:85,799,695...85,807,068
Ensembl chr16:85,798,633...85,807,068 		JBrowse link
G COX5A cytochrome c oxidase subunit 5A enables ISO
TAS		 (PMID:2853101) RGD
PINC		 PMID:2853101 PMID:7601105 RGD:727762 NCBI chr15:74,919,791...74,938,073
Ensembl chr15:74,919,791...74,938,083 		JBrowse link
G COX5B cytochrome c oxidase subunit 5B enables TAS (PMID:1646156) PINC PMID:1646156 NCBI chr 2:97,646,062...97,648,383
Ensembl chr 2:97,646,062...97,648,383 		JBrowse link
G COX6B1 cytochrome c oxidase subunit 6B1 enables NAS (PMID:2172092) UniProt PMID:2172092 NCBI chr19:35,648,323...35,658,782
Ensembl chr19:35,648,323...35,658,782 		JBrowse link
G COX7A1 cytochrome c oxidase subunit 7A1 enables
contributes_to		 TAS
ISO		 (PMID:1327965)
(PMID:22119795), (PMID:22869013)		 PINC
UniProt		 PMID:1327965 PMID:22119795 PMID:22869013 NCBI chr19:36,150,922...36,152,447
Ensembl chr19:36,150,922...36,152,449 		JBrowse link
G COX7A2L cytochrome c oxidase subunit 7A2 like enables TAS (PMID:9418891) PINC PMID:9418891 NCBI chr 2:42,335,559...42,368,957
Ensembl chr 2:42,333,546...42,425,088 		JBrowse link
G COX7B cytochrome c oxidase subunit 7B enables TAS (PMID:8382530) PINC PMID:8382530 NCBI chr  X:77,899,468...77,907,376
Ensembl chr  X:77,899,440...77,907,376 		JBrowse link
G COX8A cytochrome c oxidase subunit 8A enables TAS (PMID:2543673) PINC PMID:2543673 NCBI chr11:63,974,620...63,976,543
Ensembl chr11:63,974,620...63,976,543 		JBrowse link
G CYB5A cytochrome b5 type A enables TAS (PMID:1712589) PINC PMID:1712589 NCBI chr18:74,250,846...74,291,963
Ensembl chr18:74,250,846...74,291,973 		JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I enables
contributes_to		 IEA
IBA
IMP		 (PMID:12140182) RHEA
GO_Central
UniProt
Ensembl
InterPro		 PMID:12140182 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr MT:5,904...7,445
Ensembl chr MT:5,904...7,445 		JBrowse link
G MT-CO2 mitochondrially encoded cytochrome c oxidase II enables
contributes_to		 IEA
IBA
NAS
IMP		 (PMID:2550900)
(PMID:10486321)		 RHEA
GO_Central
UniProt
InterPro		 PMID:2550900 PMID:10486321 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 NCBI chr MT:7,586...8,269
Ensembl chr MT:7,586...8,269 		JBrowse link
G MT-CO3 mitochondrially encoded cytochrome c oxidase III enables
contributes_to		 IEA
IBA		 UniProt
GO_Central
InterPro
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 NCBI chr MT:9,207...9,990
Ensembl chr MT:9,207...9,990 		JBrowse link
G MTCO2P12 MT-CO2 pseudogene 12 enables
contributes_to		 IEA
IMP
NAS
IBA		 (PMID:10486321)
(PMID:2550900)		 RHEA
UniProt
InterPro
GO_Central		 PMID:2550900 PMID:10486321 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 NCBI chr 1:632,757...633,438
Ensembl chr 1:632,757...633,438 		JBrowse link
G SURF1 SURF1 cytochrome c oxidase assembly factor enables IEA Ensembl GO_REF:0000107 NCBI chr 9:133,351,758...133,356,487
Ensembl chr 9:133,351,758...133,356,676 		JBrowse link
Term paths to the root
Path 1
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  molecular_function 19683
    electron transfer activity 118
      cytochrome-c oxidase activity 14
Path 2
Term Annotations click to browse term
  molecular_function 19683
    transporter activity 1301
      transmembrane transporter activity 1180
        active transmembrane transporter activity 466
          primary active transmembrane transporter activity 171
            oxidoreduction-driven active transmembrane transporter activity 67
              cytochrome-c oxidase activity 14
paths to the root