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ONTOLOGY REPORT - ANNOTATIONS

Term:cytochrome-c oxidase activity
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Accession:GO:0004129 term browser browse the term
Definition:Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Comment:The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment.
Synonyms:narrow_synonym: aa3-type cytochrome c oxidase;   ba3-type cytochrome c oxidase;   caa3-type cytochrome c oxidase;   cbb3-type cytochrome c oxidase;   cytochrome a3 activity;   cytochrome aa3 activity;   indophenol oxidase;   indophenolase
 related_synonym: complex IV (mitochondrial electron transport) activity;   cytochrome oxidase activity;   warburg's respiratory enzyme activity
 xref: EC:7.1.1.9;   MetaCyc:CYTOCHROME-C-OXIDASE-RXN;   RHEA:11436;   reactome:R-HSA-163214 "Electron transfer from reduced cytochrome c to molecular oxygen"


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cytochrome-c oxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COX4I2 cytochrome c oxidase subunit 4I2 enables IEA Ensembl GO_REF:0000107 NCBI chr24:21,122,033...21,128,368
Ensembl chr24:21,120,213...21,128,320 		JBrowse link
G COX5A cytochrome c oxidase subunit Va ISO RGD PMID:7601105 RGD:727762 NCBI chr30:37,955,203...37,968,111
Ensembl chr30:37,905,827...37,968,111 		JBrowse link
G COX7A1 cytochrome c oxidase subunit 7A1 contributes_to ISO (PMID:22119795), (PMID:22869013) UniProt PMID:22119795 PMID:22869013 NCBI chr 1:116,547,179...116,548,917
Ensembl chr 1:116,547,282...116,548,917 		JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I enables
contributes_to		 IEA
IBA
ISS		 InterPro
GO_Central
UniProt
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000116 NCBI chr MT:5,349...6,893
Ensembl chr MT:5,349...6,893 		JBrowse link
G MT-CO2 mitochondrially encoded cytochrome c oxidase II contributes_to
enables		 ISS
IBA
IEA		 UniProt
GO_Central
InterPro
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000116 NCBI chr MT:7,034...7,717
Ensembl chr MT:7,034...7,717 		JBrowse link
G MT-CO3 mitochondrially encoded cytochrome c oxidase III enables
contributes_to		 IEA
IBA		 RHEA
GO_Central
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 NCBI chr MT:8,644...9,427
Ensembl chr MT:8,644...9,427 		JBrowse link
G SURF1 SURF1 cytochrome c oxidase assembly factor enables IEA Ensembl GO_REF:0000107 NCBI chr 9:49,786,562...49,790,004
Ensembl chr 9:49,786,085...49,790,148 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21949
    electron transfer activity 49
      cytochrome-c oxidase activity 7
Path 2
Term Annotations click to browse term
  molecular_function 21949
    transporter activity 1273
      transmembrane transporter activity 1167
        active transmembrane transporter activity 411
          primary active transmembrane transporter activity 141
            oxidoreduction-driven active transmembrane transporter activity 30
              cytochrome-c oxidase activity 7
paths to the root