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ONTOLOGY REPORT - ANNOTATIONS

Term:cytochrome-c oxidase activity
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Accession:GO:0004129 term browser browse the term
Definition:Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Comment:The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment.
Synonyms:narrow_synonym: aa3-type cytochrome c oxidase;   ba3-type cytochrome c oxidase;   caa3-type cytochrome c oxidase;   cbb3-type cytochrome c oxidase;   cytochrome a3 activity;   cytochrome aa3 activity;   indophenol oxidase;   indophenolase
 related_synonym: complex IV (mitochondrial electron transport) activity;   cytochrome oxidase activity;   warburg's respiratory enzyme activity
 xref: EC:7.1.1.9;   MetaCyc:CYTOCHROME-C-OXIDASE-RXN;   RHEA:11436;   reactome:R-HSA-163214 "Electron transfer from reduced cytochrome c to molecular oxygen"


show annotations for term's descendants           Sort by:
cytochrome-c oxidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cox4i2 cytochrome c oxidase subunit 4i2 enables ISO
IEA		 (PMID:11311561)
GO_REF:0000107		 RGD
Ensembl		 PMID:11311561 GO_REF:0000107 NCBI chr 3:141,228,443...141,239,337
Ensembl chr 3:141,228,443...141,239,331 		JBrowse link
G Cox5a cytochrome c oxidase subunit 5A IDA
TAS		 RGD PMID:7601105 PMID:2544858 RGD:727762, RGD:728245 NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781 		JBrowse link
G Cox5b cytochrome c oxidase subunit 5B TAS RGD PMID:8206867 RGD:728215 NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052 		JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 TAS RGD PMID:8144025 RGD:727615 NCBI chr 1:182,788,528...182,790,746
Ensembl chr 1:182,788,528...182,789,274 		JBrowse link
G Cox7a1 cytochrome c oxidase subunit 7A1 contributes_to ISO (PMID:22119795), (PMID:22869013) RGD PMID:22119795 PMID:22869013 NCBI chr 1:85,422,162...85,447,530
Ensembl chr 1:85,441,871...85,445,151 		JBrowse link
G Cox8b cytochrome c oxidase, subunit VIIIb TAS RGD PMID:8939982 RGD:727764 NCBI chr 1:195,977,183...195,978,643 JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I contributes_to
enables		 ISO
ISS
IBA		 (PMID:12140182)
GO_REF:0000024
GO_REF:0000033
(PMID:18729827)		 RGD
UniProt
GO_Central		 PMID:12140182 PMID:18729827 GO_REF:0000024 GO_REF:0000033 NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II contributes_to ISO
ISS
IBA		 (PMID:10486321)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:10486321 GO_REF:0000024 GO_REF:0000033 NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III contributes_to IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382 		JBrowse link
G Surf1 SURF1, cytochrome c oxidase assembly factor enables ISO MGI:2450930 (PMID:12566387), (PMID:23838831) RGD PMID:12566387 PMID:23838831 NCBI chr 3:10,241,793...10,244,686
Ensembl chr 3:10,241,837...10,263,315 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20633
    electron transfer activity 58
      cytochrome-c oxidase activity 10
Path 2
Term Annotations click to browse term
  molecular_function 20633
    transporter activity 1253
      transmembrane transporter activity 1153
        active transmembrane transporter activity 447
          primary active transmembrane transporter activity 153
            oxidoreduction-driven active transmembrane transporter activity 35
              cytochrome-c oxidase activity 10
paths to the root