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Term:carbonyl reductase (NADPH) activity
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Accession:GO:0004090 term browser browse the term
Definition:Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+.
Synonyms:exact_synonym: NADPH-dependent carbonyl reductase activity;   NADPH2-dependent carbonyl reductase activity;   carbonyl reductase activity;   nonspecific NADPH-dependent carbonyl reductase activity;   secondary-alcohol:NADP+ oxidoreductase activity
 narrow_synonym: prostaglandin 9-ketoreductase activity;   xenobiotic ketone reductase activity
 related_synonym: ALR3;   aldehyde reductase 1;   aldehyde reductase I activity
 xref: EC:;   MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN;   RHEA:19257;   reactome:R-HSA-8937419 "CBR3 reduces DOX to DOXOL"

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carbonyl reductase (NADPH) activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cbr1 carbonyl reductase 1 JBrowse link 11 33,813,041 33,815,418 RGD:634703
G Cbr3 carbonyl reductase 3 JBrowse link 11 33,909,417 33,917,674 RGD:2316293
G Dcxr dicarbonyl and L-xylulose reductase JBrowse link 10 109,906,119 109,909,696 RGD:13792537
G Dhrs2 dehydrogenase/reductase 2 JBrowse link 15 33,876,701 33,891,559 RGD:1624291
G Dhrs4 dehydrogenase/reductase 4 JBrowse link 15 34,155,043 34,167,073 RGD:1624291
G LOC688320 similar to Lung carbonyl reductase [NADPH] (NADPH-dependent carbonyl reductase) (LCR) (Adipocyte P27 protein) (AP27) JBrowse link 10 109,911,918 109,944,190 RGD:13792537
G LOC688321 similar to Lung carbonyl reductase [NADPH] (NADPH-dependent carbonyl reductase) (LCR) (Adipocyte P27 protein) (AP27) JBrowse link 10 109,949,168 109,953,268 RGD:13792537

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  molecular_function 19527
    catalytic activity 6039
      oxidoreductase activity 845
        oxidoreductase activity, acting on CH-OH group of donors 147
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 138
            carbonyl reductase (NADPH) activity 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.