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ONTOLOGY REPORT - ANNOTATIONS


Term:aldo-keto reductase (NADP) activity
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Accession:GO:0004033 term browser browse the term
Definition:Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
Synonyms:exact_synonym: NADPH-dependent aldo-keto reductase activity;   aldo-keto reductase activity
 narrow_synonym: alcohol dehydrogenase (NADP+) activity
 xref: Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-";   reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one";   reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol";   reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one";   reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol";   reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one";   reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one";   reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol";   reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol";   reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol";   reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one";   reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one";   reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol";   reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL";   reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH";   reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione";   reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA";   reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA";   reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3";   reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3"


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aldo-keto reductase (NADP) activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b7 aldo-keto reductase family 1, member B7 TAS RGD PMID:12193556 RGD:628357 NCBI chr 4:61,850,256...61,879,733
Ensembl chr 4:61,850,348...61,862,526
JBrowse link
G Akr1c15 aldo-keto reductase family 1, member C15 IDA PMID:17574202 UniProt PMID:17574202 RGD:13792520 NCBI chr17:69,835,338...69,862,093
Ensembl chr17:69,835,330...69,862,110
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 IDA RGD PMID:8977402 RGD:10053609 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 NAS
TAS
RGD PMID:12071861, PMID:12071861 RGD:625492, RGD:625492 NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 IDA RGD PMID:8234296 RGD:632009 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Kcnab1 potassium voltage-gated channel subfamily A member regulatory beta subunit 1 IDA
IBA
PMID:18222921
PMID:21873635
UniProt
GO_Central
PMID:18222921, PMID:21873635 RGD:10047381, RGD:13792537 NCBI chr 2:155,555,798...156,011,438
Ensembl chr 2:155,718,359...156,009,526
JBrowse link
G Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 IDA
IBA
PMID:18672894
PMID:21873635
UniProt
GO_Central
PMID:18672894, PMID:21873635 RGD:10047329, RGD:13792537 NCBI chr 5:169,570,327...169,658,875
Ensembl chr 5:169,572,517...169,658,875
JBrowse link
G Kcnab3 potassium voltage-gated channel subfamily A regulatory beta subunit 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:55,927,228...55,933,653
Ensembl chr10:55,927,223...55,933,653
JBrowse link
G Miox myo-inositol oxygenase ISO
ISS
IEA
(MGI:MGI:1889080|PMID:10944187)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:10944187 GO_REF:0000024, GO_REF:0000107, MGI:MGI:1889080 NCBI chr 7:130,308,707...130,311,205
Ensembl chr 7:130,308,532...130,313,727
JBrowse link
alcohol dehydrogenase (NADP+) activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 ISO
IBA
(PMID:19013440)
PMID:21873635
RGD PMID:19013440, PMID:21873635 RGD:13792537 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:61,850,256...61,879,733
Ensembl chr 4:61,850,348...61,862,526
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c12 aldo-keto reductase family 1, member C12 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,695,532...69,711,654
Ensembl chr17:69,695,550...69,711,689
JBrowse link
G Akr1c12l1 aldo-keto reductase family 1, member C12-like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,588,119...69,599,168
Ensembl chr17:69,588,085...69,599,142
JBrowse link
G Akr1c13 aldo-keto reductase family 1, member C13 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,614,323...69,647,772
Ensembl chr17:69,634,890...69,647,765
JBrowse link
G Akr1c14 aldo-keto reductase family 1, member C14 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,806,095...69,827,125
Ensembl chr17:69,806,065...69,827,112
JBrowse link
G Akr1c15 aldo-keto reductase family 1, member C15 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,835,338...69,862,093
Ensembl chr17:69,835,330...69,862,110
JBrowse link
G Akr1c19 aldo-keto reductase family 1, member C19 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,653,003...69,675,204
Ensembl chr17:69,654,170...69,675,203
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Akr1e2 aldo-keto reductase family 1, member E2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,365,437...69,379,944
Ensembl chr17:69,365,453...69,379,947
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 ISO
ISS
(PMID:1737758)
GO_REF:0000024
RGD
UniProt
PMID:1737758 GO_REF:0000024 NCBI chr10:47,490,168...47,499,855
Ensembl chr10:47,490,153...47,499,876
JBrowse link
G LOC100910708 aldose reductase-related protein 1-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:62,015,923...62,031,795
Ensembl chr 4:62,019,970...62,030,874
JBrowse link
G Rdh14 retinol dehydrogenase 14 ISO (MGI:MGI:5618338|PMID:25533474) RGD PMID:25533474 MGI:MGI:5618338 NCBI chr 6:36,106,926...36,112,069
Ensembl chr 6:36,107,147...36,112,064
JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,468,427...69,497,132
Ensembl chr17:69,468,427...69,497,132
JBrowse link
alditol:NADP+ 1-oxidoreductase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide ISO (MGI:MGI:1346361|PMID:10514444) RGD PMID:10514444 MGI:MGI:1346361 NCBI chr 2:243,702,035...243,720,063
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 ISO
IBA
(MGI:MGI:2684045|PMID:14667815), (MGI:MGI:3588122|PMID:15769935)
PMID:21873635
RGD PMID:14667815, PMID:15769935, PMID:21873635 MGI:MGI:2684045, MGI:MGI:3588122, RGD:13792537 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B IDA
IBA
ISO
PMID:21873635
(PMID:1420136), (PMID:15272156), (PMID:8435445)
(MGI:MGI:70761|PMID:7851421)
RGD PMID:1420136, PMID:7851421, PMID:8435445, PMID:15272156, PMID:2114645, PMID:21873635 MGI:MGI:70761, RGD:1626085, RGD:13792537 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:20709016, PMID:21873635 RGD:6903952, RGD:13792537 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 TAS
IBA
PMID:21873635 RGD
GO_Central
PMID:12193556, PMID:21873635 RGD:628357, RGD:13792537 NCBI chr 4:61,850,256...61,879,733
Ensembl chr 4:61,850,348...61,862,526
JBrowse link
G Akr1b8 aldo-keto reductase family 1, member B8 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:61,772,064...61,784,637
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c12 aldo-keto reductase family 1, member C12 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,695,532...69,711,654
Ensembl chr17:69,695,550...69,711,689
JBrowse link
G Akr1c12l1 aldo-keto reductase family 1, member C12-like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,588,119...69,599,168
Ensembl chr17:69,588,085...69,599,142
JBrowse link
G Akr1c13 aldo-keto reductase family 1, member C13 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,614,323...69,647,772
Ensembl chr17:69,634,890...69,647,765
JBrowse link
G Akr1c14 aldo-keto reductase family 1, member C14 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,806,095...69,827,125
Ensembl chr17:69,806,065...69,827,112
JBrowse link
G Akr1c15 aldo-keto reductase family 1, member C15 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,835,338...69,862,093
Ensembl chr17:69,835,330...69,862,110
JBrowse link
G Akr1c19 aldo-keto reductase family 1, member C19 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,653,003...69,675,204
Ensembl chr17:69,654,170...69,675,203
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 ISO
IBA
(PMID:21232532)
PMID:21873635
RGD PMID:21232532, PMID:21873635 RGD:13792537 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 IDA
IBA
ISO
PMID:21873635
(PMID:21232532)
RGD PMID:21232532, PMID:8977402, PMID:21873635 RGD:10053609, RGD:13792537 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Akr1e2 aldo-keto reductase family 1, member E2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,365,437...69,379,944
Ensembl chr17:69,365,453...69,379,947
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 IDA RGD PMID:12071861 RGD:625492 NCBI chr 5:157,759,448...157,768,473
Ensembl chr 5:157,759,416...157,768,471
JBrowse link
G LOC100910708 aldose reductase-related protein 1-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:62,015,923...62,031,795
Ensembl chr 4:62,019,970...62,030,874
JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:69,468,427...69,497,132
Ensembl chr17:69,468,427...69,497,132
JBrowse link
NADP-retinol dehydrogenase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 IDA
ISO
(PMID:12732097) RGD PMID:12732097, PMID:20709016 RGD:6903952 NCBI chr 4:61,813,265...61,830,371
Ensembl chr 4:61,771,970...61,828,657
JBrowse link
G Dhrs13 dehydrogenase/reductase 13 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:65,329,407...65,334,533
Ensembl chr10:65,329,940...65,334,500
JBrowse link
G Rdh10 retinol dehydrogenase 10 IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 5:2,605,265...2,631,905
Ensembl chr 5:2,603,505...2,632,030
JBrowse link
G Rdh11 retinol dehydrogenase 11 ISO (PMID:12226107), (PMID:12807874) RGD PMID:12226107, PMID:12807874 NCBI chr 6:102,356,498...102,372,618
Ensembl chr 6:102,356,492...102,372,611
JBrowse link
G Rdh12 retinol dehydrogenase 12 ISO (PMID:12226107) RGD PMID:12226107 NCBI chr 6:102,392,828...102,405,750
Ensembl chr 6:102,392,828...102,405,750
JBrowse link
G Rdh13 retinol dehydrogenase 13 ISO
IBA
(PMID:18039331)
PMID:21873635
RGD PMID:18039331, PMID:21873635 RGD:13792537 NCBI chr 1:72,956,017...72,983,811
Ensembl chr 1:72,956,026...72,984,350
JBrowse link
G Rdh14 retinol dehydrogenase 14 ISO (PMID:12435598)
(MGI:MGI:6271140|PMID:12226107)
RGD PMID:12226107, PMID:12435598 MGI:MGI:6271140 NCBI chr 6:36,106,926...36,112,069
Ensembl chr 6:36,107,147...36,112,064
JBrowse link
G Rdh8 retinol dehydrogenase 8 IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 8:21,835,065...21,842,374
Ensembl chr 8:21,835,103...21,842,374
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20457
    catalytic activity 6097
      oxidoreductase activity 876
        oxidoreductase activity, acting on CH-OH group of donors 149
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 138
            aldo-keto reductase (NADP) activity 33
              alcohol dehydrogenase (NADP+) activity + 28
              pyridoxine:NADP 4-dehydrogenase activity 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.