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ONTOLOGY REPORT - ANNOTATIONS


Term:aldo-keto reductase (NADP) activity
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Accession:GO:0004033 term browser browse the term
Definition:Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
Synonyms:exact_synonym: NADPH-dependent aldo-keto reductase activity;   aldo-keto reductase activity
 narrow_synonym: alcohol dehydrogenase (NADP+) activity
 xref: Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-";   reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one";   reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol";   reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one";   reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol";   reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one";   reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one";   reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol";   reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol";   reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol";   reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one";   reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one";   reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol";   reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL";   reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH";   reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione";   reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA";   reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA";   reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3";   reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3"


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aldo-keto reductase (NADP) activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G KCNAB1 potassium voltage-gated channel subfamily A member regulatory beta subunit 1 JBrowse link 3 153,175,465 153,594,375 RGD:9068941
G KCNAB2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 JBrowse link 1 4,755,412 4,866,424 RGD:9068941
G MIOX myo-inositol oxygenase JBrowse link 22 30,735,206 30,738,738 RGD:9068941
alcohol dehydrogenase (NADP+) activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AKR1B10 aldo-keto reductase family 1 member B10 JBrowse link 7 126,486,012 126,499,852 RGD:9068941
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 JBrowse link 17 31,384,740 31,395,719 RGD:9068941
G RDH14 retinol dehydrogenase 14 JBrowse link 2A 18,534,357 18,540,325 RGD:9068941
alditol:NADP+ 1-oxidoreductase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide JBrowse link 4 91,522,444 91,543,086 RGD:9068941
G AKR1A1 aldo-keto reductase family 1 member A1 JBrowse link 1 44,853,867 44,871,764 RGD:9068941
G AKR1B1 aldo-keto reductase family 1 member B JBrowse link 7 126,400,861 126,417,756 RGD:9068941
G AKR1B10 aldo-keto reductase family 1 member B10 JBrowse link 7 126,486,012 126,499,852 RGD:9068941
NADP-retinol dehydrogenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AKR1B10 aldo-keto reductase family 1 member B10 JBrowse link 7 126,486,012 126,499,852 RGD:9068941
G RDH11 retinol dehydrogenase 11 JBrowse link 14 48,256,951 48,275,831 RGD:9068941
G RDH12 retinol dehydrogenase 12 JBrowse link 14 48,297,854 48,314,502 RGD:9068941
G RDH13 retinol dehydrogenase 13 JBrowse link 19 52,081,674 52,107,781 RGD:9068941
G RDH14 retinol dehydrogenase 14 JBrowse link 2A 18,534,357 18,540,325 RGD:9068941

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Term Annotations click to browse term
  molecular_function 14772
    catalytic activity 3690
      oxidoreductase activity 487
        oxidoreductase activity, acting on CH-OH group of donors 99
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 88
            aldo-keto reductase (NADP) activity 12
              alcohol dehydrogenase (NADP+) activity + 9
              pyridoxine:NADP 4-dehydrogenase activity 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.