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ONTOLOGY REPORT - ANNOTATIONS


Term:aldo-keto reductase (NADP) activity
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Accession:GO:0004033 term browser browse the term
Definition:Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
Synonyms:exact_synonym: NADPH-dependent aldo-keto reductase activity;   aldo-keto reductase activity
 narrow_synonym: alcohol dehydrogenase (NADP+) activity
 xref: Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-";   reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one";   reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol";   reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one";   reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol";   reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one";   reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one";   reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol";   reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol";   reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol";   reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one";   reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one";   reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol";   reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL";   reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH";   reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione";   reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA";   reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA";   reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3";   reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3"


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aldo-keto reductase (NADP) activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1b7 aldo-keto reductase family 1, member B7 JBrowse link 4 61,850,256 61,879,733 RGD:628357
G Akr1c15 aldo-keto reductase family 1, member C15 JBrowse link 17 69,835,338 69,862,093 RGD:13792520
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:10053609
G Akr7a2 aldo-keto reductase family 7, member A2 JBrowse link 5 157,759,448 157,768,473 RGD:625492
G Akr7a3 aldo-keto reductase family 7 member A3 JBrowse link 5 157,801,120 157,813,756 RGD:632009
G Kcnab1 potassium voltage-gated channel subfamily A member regulatory beta subunit 1 JBrowse link 2 155,555,798 156,011,438 RGD:10047381
RGD:13792537
G Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 JBrowse link 5 169,570,327 169,658,875 RGD:10047329
RGD:13792537
G Kcnab3 potassium voltage-gated channel subfamily A regulatory beta subunit 3 JBrowse link 10 55,927,228 55,933,653 RGD:13792537
G Miox myo-inositol oxygenase JBrowse link 7 130,308,707 130,311,205 RGD:1624291
RGD:1600115
alcohol dehydrogenase (NADP+) activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1a1 aldo-keto reductase family 1 member A1 JBrowse link 5 135,482,068 135,498,693 RGD:13792537
G Akr1b1 aldo-keto reductase family 1 member B JBrowse link 4 61,706,866 61,720,959 RGD:13792537
G Akr1b10 aldo-keto reductase family 1 member B10 JBrowse link 4 61,813,265 61,830,371 RGD:1624291
RGD:13792537
G Akr1b7 aldo-keto reductase family 1, member B7 JBrowse link 4 61,850,256 61,879,733 RGD:13792537
G Akr1b8 aldo-keto reductase family 1, member B8 JBrowse link 4 61,772,064 61,784,637 RGD:13792537
G Akr1c1 aldo-keto reductase family 1, member C1 JBrowse link 17 69,441,253 69,460,334 RGD:13792537
G Akr1c12 aldo-keto reductase family 1, member C12 JBrowse link 17 69,695,532 69,711,654 RGD:13792537
G Akr1c12l1 aldo-keto reductase family 1, member C12-like 1 JBrowse link 17 69,588,119 69,599,168 RGD:13792537
G Akr1c13 aldo-keto reductase family 1, member C13 JBrowse link 17 69,614,323 69,647,772 RGD:13792537
G Akr1c14 aldo-keto reductase family 1, member C14 JBrowse link 17 69,806,095 69,827,125 RGD:13792537
G Akr1c15 aldo-keto reductase family 1, member C15 JBrowse link 17 69,835,338 69,862,093 RGD:13792537
G Akr1c19 aldo-keto reductase family 1, member C19 JBrowse link 17 69,653,003 69,675,204 RGD:13792537
G Akr1c2 aldo-keto reductase family 1, member C2 JBrowse link 17 69,388,337 69,435,160 RGD:13792537
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:13792537
G Akr1d1 aldo-keto reductase family 1, member D1 JBrowse link 4 65,110,706 65,143,930 RGD:13792537
G Akr1e2 aldo-keto reductase family 1, member E2 JBrowse link 17 69,365,437 69,379,944 RGD:13792537
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 JBrowse link 10 47,490,168 47,499,855 RGD:1624291
RGD:1600115
G LOC100910708 aldose reductase-related protein 1-like JBrowse link 4 62,015,923 62,031,795 RGD:13792537
G Rdh14 retinol dehydrogenase 14 JBrowse link 6 36,106,926 36,112,069 RGD:1624291
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase JBrowse link 17 69,468,427 69,497,132 RGD:13792537
alditol:NADP+ 1-oxidoreductase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide JBrowse link 2 243,702,035 243,720,063 RGD:1624291
G Akr1a1 aldo-keto reductase family 1 member A1 JBrowse link 5 135,482,068 135,498,693 RGD:1624291
RGD:13792537
G Akr1b1 aldo-keto reductase family 1 member B JBrowse link 4 61,706,866 61,720,959 RGD:1626085
RGD:13792537
RGD:1624291
G Akr1b10 aldo-keto reductase family 1 member B10 JBrowse link 4 61,813,265 61,830,371 RGD:6903952
RGD:13792537
G Akr1b7 aldo-keto reductase family 1, member B7 JBrowse link 4 61,850,256 61,879,733 RGD:628357
RGD:13792537
G Akr1b8 aldo-keto reductase family 1, member B8 JBrowse link 4 61,772,064 61,784,637 RGD:13792537
G Akr1c1 aldo-keto reductase family 1, member C1 JBrowse link 17 69,441,253 69,460,334 RGD:13792537
G Akr1c12 aldo-keto reductase family 1, member C12 JBrowse link 17 69,695,532 69,711,654 RGD:13792537
G Akr1c12l1 aldo-keto reductase family 1, member C12-like 1 JBrowse link 17 69,588,119 69,599,168 RGD:13792537
G Akr1c13 aldo-keto reductase family 1, member C13 JBrowse link 17 69,614,323 69,647,772 RGD:13792537
G Akr1c14 aldo-keto reductase family 1, member C14 JBrowse link 17 69,806,095 69,827,125 RGD:13792537
G Akr1c15 aldo-keto reductase family 1, member C15 JBrowse link 17 69,835,338 69,862,093 RGD:13792537
G Akr1c19 aldo-keto reductase family 1, member C19 JBrowse link 17 69,653,003 69,675,204 RGD:13792537
G Akr1c2 aldo-keto reductase family 1, member C2 JBrowse link 17 69,388,337 69,435,160 RGD:1624291
RGD:13792537
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:10053609
RGD:13792537
RGD:1624291
G Akr1d1 aldo-keto reductase family 1, member D1 JBrowse link 4 65,110,706 65,143,930 RGD:13792537
G Akr1e2 aldo-keto reductase family 1, member E2 JBrowse link 17 69,365,437 69,379,944 RGD:13792537
G Akr7a2 aldo-keto reductase family 7, member A2 JBrowse link 5 157,759,448 157,768,473 RGD:625492
G LOC100910708 aldose reductase-related protein 1-like JBrowse link 4 62,015,923 62,031,795 RGD:13792537
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase JBrowse link 17 69,468,427 69,497,132 RGD:13792537
NADP-retinol dehydrogenase activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1b1 aldo-keto reductase family 1 member B JBrowse link 4 61,706,866 61,720,959 RGD:1600115
G Akr1b10 aldo-keto reductase family 1 member B10 JBrowse link 4 61,813,265 61,830,371 RGD:6903952
RGD:1624291
G Dhrs13 dehydrogenase/reductase 13 JBrowse link 10 65,329,407 65,334,533 RGD:13792537
G Rdh10 retinol dehydrogenase 10 JBrowse link 5 2,605,265 2,631,905 RGD:1600115
G Rdh11 retinol dehydrogenase 11 JBrowse link 6 102,356,498 102,372,618 RGD:1624291
G Rdh12 retinol dehydrogenase 12 JBrowse link 6 102,392,828 102,405,750 RGD:1624291
G Rdh13 retinol dehydrogenase 13 JBrowse link 1 72,956,017 72,983,811 RGD:1624291
RGD:13792537
G Rdh14 retinol dehydrogenase 14 JBrowse link 6 36,106,926 36,112,069 RGD:1624291
G Rdh8 retinol dehydrogenase 8 JBrowse link 8 21,835,065 21,842,374 RGD:1600115

Term paths to the root
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Term Annotations click to browse term
  molecular_function 20377
    catalytic activity 6066
      oxidoreductase activity 867
        oxidoreductase activity, acting on CH-OH group of donors 149
          oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 138
            aldo-keto reductase (NADP) activity 33
              alcohol dehydrogenase (NADP+) activity + 28
              pyridoxine:NADP 4-dehydrogenase activity 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.