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ONTOLOGY REPORT - ANNOTATIONS


Term:adenylate cyclase activity
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Accession:GO:0004016 term browser browse the term
Definition:Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
Synonyms:exact_synonym: adenylyl cyclase activity
 related_synonym: 3',5'-cyclic AMP synthetase activity;   ATP diphosphate-lyase (cyclizing) activity;   ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity;   ATP pyrophosphate-lyase activity;   adenyl cyclase activity;   adenylylcyclase activity;   cAMP generating peptide activity
 xref: EC:4.6.1.1;   MetaCyc:ADENYLATECYC-RXN;   RHEA:15389;   Reactome:R-HSA-5211224 "Anthrax cya catalyzes the conversion of ATP to cAMP";   Reactome:R-HSA-9712183 "ADCY3:GNAL:GTP converts ATP to cAMP";   reactome:R-HSA-164377 "Activated Adenylate cyclase catalyses cAMP synthesis";   reactome:R-HSA-170676 "Adenylate cyclase converts ATP into cyclic AMP";   reactome:R-HSA-381607 "Activated Adenylyl cyclase synthesizes cyclic AMP";   reactome:R-HSA-392129 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate";   reactome:R-HSA-5610727 "GPR161 promotes cAMP production in a G alpha(s)-dependent manner"



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adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy1 adenylate cyclase 1 enables ISO
IBA
MGI:1341110 (PMID:10482244)
GO_REF:0000033
RGD
GO_Central
PMID:10482244 GO_REF:0000033 NCBI chr14:86,125,119...86,234,459
Ensembl chr14:81,911,099...82,028,969
JBrowse link
G Adcy10 adenylate cyclase 10 enables IDA
IBA
ISO
GO_REF:0000033
(PMID:12609998), (PMID:15659711)
GO_Central
RGD
PMID:12609998 PMID:15659711 PMID:9874775 PMID:16250004 PMID:7225326 GO_REF:0000033, RGD:1299450, RGD:329412471, RGD:2313177 NCBI chr13:80,280,595...80,366,939
Ensembl chr13:77,768,468...77,833,951
JBrowse link
G Adcy2 adenylate cyclase 2 enables IDA
IBA
IEA
GO_REF:0000033
GO_REF:0000117
PMID:10427002
PMID:18164588
GO_Central
UniProt
RGD
PMID:1719547 PMID:10427002 PMID:18164588 PMID:12711600 PMID:11738086 GO_REF:0000033 GO_REF:0000117, RGD:724792, RGD:10400857, RGD:8553431, RGD:2312674, RGD:2312641 NCBI chr 1:36,204,054...36,650,645
Ensembl chr 1:34,375,895...34,822,236
JBrowse link
G Adcy3 adenylate cyclase 3 enables IDA
IBA
IEA
ISO
TAS
PMID:24363043
GO_REF:0000033
GO_REF:0000117
(PMID:11055432)
Reactome:R-RNO-9713735
GO_REF:0000003
GO_Central
UniProt
RGD
Reactome
PMID:11055432 PMID:24363043 GO_REF:0000003 GO_REF:0000033 GO_REF:0000117 Reactome:R-RNO-9713735, RGD:10400870 NCBI chr 6:32,819,602...32,923,174
Ensembl chr 6:27,124,828...27,203,686
JBrowse link
G Adcy4 adenylate cyclase 4 enables IDA
IEA
IBA
PMID:8900209
GO_REF:0000117
GO_REF:0000033
UniProt
GO_Central
RGD
PMID:1946437 PMID:11738086 PMID:12711600 PMID:8900209 GO_REF:0000033 GO_REF:0000117, RGD:69739, RGD:2312641, RGD:2312674, RGD:8554340 NCBI chr15:33,236,201...33,252,070
Ensembl chr15:29,266,287...29,282,108
JBrowse link
G Adcy5 adenylate cyclase 5 enables IDA
IBA
IEA
ISO
GO_REF:0000033
GO_REF:0000117
(PMID:8119955), (PMID:9748257)
MGI:2387896|MGI:2662295 (PMID:12223546), (PMID:12665504), (PMID:17593019), (PMID:19574217)
GO_REF:0000003
(PMID:15385642), (PMID:24700542), (PMID:24740569)
GO_Central
UniProt
RGD
PMID:8119955 PMID:9748257 PMID:12223546 PMID:12665504 PMID:15385642 More... GO_REF:0000003 GO_REF:0000033 GO_REF:0000117, RGD:69740, RGD:2315004, RGD:2312674, RGD:2312641 NCBI chr11:78,976,861...79,123,343
Ensembl chr11:65,471,612...65,618,974
JBrowse link
G Adcy6 adenylate cyclase 6 enables IDA
IBA
IEA
ISO
GO_REF:0000033
GO_REF:0000117
(PMID:17593019), (PMID:20466003)
(PMID:8119955)
PMID:15385642
GO_REF:0000003
(PMID:17916776), (PMID:18403039), (PMID:23842570)
GO_Central
UniProt
RGD
PMID:8119955 PMID:17593019 PMID:17916776 PMID:18403039 PMID:20466003 More... GO_REF:0000003 GO_REF:0000033 GO_REF:0000117, RGD:1598749, RGD:8554216, RGD:2312641, RGD:2312674, RGD:2313211, RGD:2315004 NCBI chr 7:131,621,860...131,642,923
Ensembl chr 7:129,742,838...129,763,754
JBrowse link
G Adcy7 adenylate cyclase 7 enables IDA
IBA
ISO
GO_REF:0000033
(PMID:18205980), (PMID:18541530), (PMID:20505140), (PMID:23178822), (PMID:23229509)
(PMID:11113152), (PMID:17760784), (PMID:18541530), (PMID:23178822), (PMID:23229509), (PMID:23842570)
GO_Central
RGD
PMID:11113152 PMID:17760784 PMID:18205980 PMID:18541530 PMID:20505140 More... GO_REF:0000033, RGD:2312674 NCBI chr19:34,913,154...34,972,366
Ensembl chr19:18,740,875...18,776,311
JBrowse link
G Adcy8 adenylate cyclase 8 enables ISO
IBA
IEA
MGI:99677 (PMID:10482244), (PMID:10799557)
GO_REF:0000033
GO_REF:0000117
RGD
GO_Central
UniProt
PMID:10482244 PMID:10799557 GO_REF:0000033 GO_REF:0000117 NCBI chr 7:98,306,434...98,555,687
Ensembl chr 7:96,417,324...96,665,911
JBrowse link
G Adcy9 adenylate cyclase 9 enables ISO
IBA
(PMID:9628827)
GO_REF:0000033
(PMID:8662814)
RGD
GO_Central
PMID:8662814 PMID:9628827 GO_REF:0000033 NCBI chr10:11,645,373...11,768,462
Ensembl chr10:11,139,446...11,262,066
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 contributes_to IDA RGD PMID:22122229 RGD:10401947 NCBI chr 2:169,716,684...169,780,360
Ensembl chr 2:167,418,640...167,481,671
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 contributes_to IDA RGD PMID:22122229 RGD:10401947 NCBI chr 2:169,646,897...169,697,060
Ensembl chr 2:167,348,825...167,398,916
JBrowse link
calcium- and calmodulin-responsive adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy1 adenylate cyclase 1 IDA RGD PMID:14985420 RGD:2312640 NCBI chr14:86,125,119...86,234,459
Ensembl chr14:81,911,099...82,028,969
JBrowse link
G Adcy3 adenylate cyclase 3 IDA RGD PMID:12711600 RGD:2312674 NCBI chr 6:32,819,602...32,923,174
Ensembl chr 6:27,124,828...27,203,686
JBrowse link
G Adcy5 adenylate cyclase 5 IDA RGD PMID:10894801 RGD:2315006 NCBI chr11:78,976,861...79,123,343
Ensembl chr11:65,471,612...65,618,974
JBrowse link
G Adcy6 adenylate cyclase 6 enables IDA
ISO
(PMID:1379717) RGD PMID:1379717 PMID:10894801 RGD:2315006 NCBI chr 7:131,621,860...131,642,923
Ensembl chr 7:129,742,838...129,763,754
JBrowse link
G Adcy8 adenylate cyclase 8 enables IDA
IEA
ISO
PMID:11856299
PMID:13680124
PMID:8557635
PMID:19158400
GO_REF:0000107
(PMID:10864938)
Ensembl
RGD
PMID:10864938 PMID:8163524 PMID:11856299 PMID:13680124 PMID:8557635 More... GO_REF:0000107, RGD:69741, RGD:13800543, RGD:2312682, RGD:13825188, RGD:13800545 NCBI chr 7:98,306,434...98,555,687
Ensembl chr 7:96,417,324...96,665,911
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21090
    catalytic activity 6125
      cyclase activity 24
        adenylate cyclase activity 12
          calcium- and calmodulin-responsive adenylate cyclase activity 5
Path 2
Term Annotations click to browse term
  molecular_function 21090
    catalytic activity 6125
      lyase activity 214
        phosphorus-oxygen lyase activity 27
          adenylate cyclase activity 12
            calcium- and calmodulin-responsive adenylate cyclase activity 5
paths to the root