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ONTOLOGY REPORT - ANNOTATIONS

Term:adenylate cyclase activity
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Accession:GO:0004016 term browser browse the term
Definition:Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate.
Synonyms:exact_synonym: adenylyl cyclase activity
 related_synonym: 3',5'-cyclic AMP synthetase activity;   ATP diphosphate-lyase (cyclizing) activity;   ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity;   ATP pyrophosphate-lyase activity;   adenyl cyclase activity;   adenylylcyclase activity;   cAMP generating peptide activity
 xref: EC:4.6.1.1;   MetaCyc:ADENYLATECYC-RXN;   RHEA:15389;   Reactome:R-HSA-5211224 "Anthrax cya catalyzes the conversion of ATP to cAMP";   Reactome:R-HSA-9712183 "ADCY3:GNAL:GTP converts ATP to cAMP";   reactome:R-HSA-164377 "Activated Adenylate cyclase catalyses cAMP synthesis";   reactome:R-HSA-170676 "Adenylate cyclase converts ATP into cyclic AMP";   reactome:R-HSA-381607 "Activated Adenylyl cyclase synthesizes cyclic AMP";   reactome:R-HSA-392129 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate";   reactome:R-HSA-5610727 "GPR161 promotes cAMP production in a G alpha(s)-dependent manner"


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adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY1 adenylate cyclase 1 enables IEA
IBA		 UniProt
TreeGrafter
GO_Central
RHEA
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 NCBI chr 7:45,574,140...45,723,116
Ensembl chr 7:45,574,140...45,723,116 		JBrowse link
G ADCY10 adenylate cyclase 10 enables IEA
IBA
ISO
IDA
TAS
NAS		 (PMID:12609998), (PMID:15659711)
(PMID:9874775)		 RHEA
GO_Central
TreeGrafter
RGD
UniProt
PINC
InterPro
Ensembl		 PMID:7225326 PMID:9874775 PMID:12609998 PMID:15659711 PMID:16250004 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 RGD:1299450 RGD:2313177 RGD:329412471 NCBI chr 1:167,809,386...167,914,134
Ensembl chr 1:167,809,386...167,914,215 		JBrowse link
G ADCY2 adenylate cyclase 2 enables ISO
IBA
IEA
ISS
NAS		 (PMID:1427768) RGD
GO_Central
TreeGrafter
BHF-UCL
UniProt
RHEA
InterPro		 PMID:1427768 PMID:1719547 PMID:11738086 PMID:12711600 GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000116 GO_REF:0000118 RGD:2312641 RGD:2312674 RGD:724792 NCBI chr 5:7,396,138...7,830,081
Ensembl chr 5:7,396,138...7,830,081 		JBrowse link
G ADCY3 adenylate cyclase 3 enables IEA
IBA
TAS
ISS		 (PMID:9920776) UniProt
GO_Central
TreeGrafter
Ensembl
InterPro
PINC
RHEA		 PMID:9920776 GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 NCBI chr 2:24,819,169...24,920,237
Ensembl chr 2:24,819,169...24,920,237 		JBrowse link
G ADCY4 adenylate cyclase 4 enables ISO
IBA
IEA
ISS		 RGD
GO_Central
TreeGrafter
BHF-UCL
UniProt
InterPro
RHEA		 PMID:1946437 PMID:11738086 PMID:12711600 GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000116 GO_REF:0000118 RGD:2312641 RGD:2312674 RGD:69739 NCBI chr14:24,318,359...24,335,071
Ensembl chr14:24,318,349...24,335,093 		JBrowse link
G ADCY5 adenylate cyclase 5 enables ISO
IEA
IBA
IMP
IDA		 (PMID:24740569)
(PMID:15385642), (PMID:24700542)		 RGD
TreeGrafter
GO_Central
UniProt
RHEA
Ensembl
InterPro		 PMID:1409703 PMID:11738086 PMID:12711600 PMID:15385642 PMID:17010343 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 RGD:2312641 RGD:2312674 RGD:2315004 RGD:69740 NCBI chr 3:123,282,296...123,449,090
Ensembl chr 3:123,282,296...123,449,090 		JBrowse link
G ADCY6 adenylate cyclase 6 enables ISO
IBA
IDA
IEA		 (PMID:17916776), (PMID:18403039), (PMID:23842570) RGD
GO_Central
UniProt
RHEA
InterPro		 PMID:11738086 PMID:12711600 PMID:15579502 PMID:15961389 PMID:17010343 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 RGD:1598749 RGD:2312641 RGD:2312674 RGD:2313211 RGD:2315004 NCBI chr12:48,766,194...48,789,974
Ensembl chr12:48,766,194...48,789,089 		JBrowse link
G ADCY7 adenylate cyclase 7 enables ISO
IEA
IBA
IMP
IDA		 (PMID:18541530), (PMID:23178822), (PMID:23229509), (PMID:23842570)
(PMID:11113152), (PMID:17760784)		 RGD
TreeGrafter
GO_Central
Ensembl
InterPro
RHEA
UniProt		 PMID:11113152 PMID:12711600 PMID:17760784 PMID:18541530 PMID:23178822 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 RGD:2312674 NCBI chr16:50,244,699...50,318,135
Ensembl chr16:50,246,137...50,318,135 		JBrowse link
G ADCY8 adenylate cyclase 8 enables IEA
IBA
TAS		 (PMID:8076676) UniProt
TreeGrafter
GO_Central
RHEA
InterPro
Ensembl
PINC		 PMID:8076676 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000118 Reactome:R-HSA-381607 NCBI chr 8:130,780,301...131,040,909
Ensembl chr 8:130,780,301...131,040,909 		JBrowse link
G ADCY9 adenylate cyclase 9 enables IEA
IBA
TAS
IDA		 (PMID:9628827) RHEA
GO_Central
UniProt
PINC
Ensembl		 PMID:9628827 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr16:3,953,387...4,116,442
Ensembl chr16:3,953,387...4,116,442 		JBrowse link
G GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 contributes_to ISO RGD PMID:22122229 RGD:10401947 NCBI chr 4:155,666,848...155,737,059
Ensembl chr 4:155,666,726...155,737,059 		JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 contributes_to
enables		 ISO
IEA		 RGD
Ensembl		 PMID:22122229 GO_REF:0000107 RGD:10401947 NCBI chr 4:155,759,021...155,807,811
Ensembl chr 4:155,758,992...155,807,811 		JBrowse link
G GUCY2C guanylate cyclase 2C enables IBA GO_Central GO_REF:0000033 NCBI chr12:14,612,632...14,696,599
Ensembl chr12:14,612,632...14,696,599 		JBrowse link
G GUCY2D guanylate cyclase 2D, retinal enables IBA GO_Central GO_REF:0000033 NCBI chr17:8,002,615...8,020,342
Ensembl chr17:8,002,615...8,020,342 		JBrowse link
G GUCY2F guanylate cyclase 2F, retinal enables IBA GO_Central GO_REF:0000033 NCBI chr  X:109,372,906...109,482,086
Ensembl chr  X:109,372,906...109,482,086 		JBrowse link
G NPR1 natriuretic peptide receptor 1 enables IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:153,678,688...153,693,992
Ensembl chr 1:153,678,688...153,693,992 		JBrowse link
G NPR2 natriuretic peptide receptor 2 enables IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 9:35,791,591...35,809,731
Ensembl chr 9:35,791,003...35,809,732 		JBrowse link
calcium- and calmodulin-responsive adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY1 adenylate cyclase 1 enables ISO
IEA
NAS
ISS		 (PMID:8314585) RGD
Ensembl
UniProt		 PMID:8314585 PMID:14985420 GO_REF:0000024 GO_REF:0000107 RGD:2312640 NCBI chr 7:45,574,140...45,723,116
Ensembl chr 7:45,574,140...45,723,116 		JBrowse link
G ADCY3 adenylate cyclase 3 ISO RGD PMID:12711600 RGD:2312674 NCBI chr 2:24,819,169...24,920,237
Ensembl chr 2:24,819,169...24,920,237 		JBrowse link
G ADCY5 adenylate cyclase 5 ISO RGD PMID:10894801 RGD:2315006 NCBI chr 3:123,282,296...123,449,090
Ensembl chr 3:123,282,296...123,449,090 		JBrowse link
G ADCY6 adenylate cyclase 6 enables ISO (PMID:1379717) RGD
MGI		 PMID:1379717 PMID:10894801 RGD:2315006 NCBI chr12:48,766,194...48,789,974
Ensembl chr12:48,766,194...48,789,089 		JBrowse link
G ADCY8 adenylate cyclase 8 enables ISO
IEA
ISS
TAS		 (PMID:8163524) RGD
Ensembl
UniProt
PINC		 PMID:8163524 GO_REF:0000024 GO_REF:0000107 RGD:69741 NCBI chr 8:130,780,301...131,040,909
Ensembl chr 8:130,780,301...131,040,909 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19566
    catalytic activity 5977
      cyclase activity 23
        adenylate cyclase activity 17
          calcium- and calmodulin-responsive adenylate cyclase activity 5
Path 2
Term Annotations click to browse term
  molecular_function 19566
    catalytic activity 5977
      lyase activity 221
        phosphorus-oxygen lyase activity 26
          adenylate cyclase activity 17
            calcium- and calmodulin-responsive adenylate cyclase activity 5
paths to the root