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ONTOLOGY REPORT - ANNOTATIONS

Term:GTPase activity
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Accession:GO:0003924 term browser browse the term
Definition:Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
Synonyms:narrow_synonym: ARF small monomeric GTPase activity;   RHEB small monomeric GTPase activity;   Rab small monomeric GTPase activity;   Ran small monomeric GTPase activity;   Ras small monomeric GTPase activity;   Rho small monomeric GTPase activity;   Sar small monomeric GTPase activity;   dynamin GTPase activity;   heterotrimeric G-protein GTPase activity;   protein-synthesizing GTPase activity;   protein-synthesizing GTPase activity, elongation;   protein-synthesizing GTPase activity, initiation;   protein-synthesizing GTPase activity, termination;   signal-recognition-particle GTPase activity;   small monomeric GTPase activity;   tubulin GTPase activity
 broad_synonym: hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement
 related_synonym: GTPase activity, coupled;   heterotrimeric G-protein GTPase, alpha-subunit;   heterotrimeric G-protein GTPase, beta-subunit;   heterotrimeric G-protein GTPase, gamma-subunit
 alt_id: GO:0061745
 xref: MetaCyc:RXN0-5462;   RHEA:19669;   Reactome:R-HSA-9018814 "RHOT1 hydrolyzes GTP";   Reactome:R-HSA-9018826 "RHOT2 hydrolyzes GTP";   Reactome:R-HSA-9640195 "RRAGA,B hydrolyzes GTP";   Reactome:R-HSA-9645598 "RRAGC,D hydrolyzes GTP";   Reactome:R-HSA-9649736 "RAS intrinsic GTPase activity hydrolyzes GTP to GDP";   reactome:R-HSA-1445143 "RAB8A,10,13,14 hydrolyze GTP";   reactome:R-HSA-1458485 "RALA hydrolyzes GTP";   reactome:R-HSA-156923 "Hydrolysis of eEF1A:GTP";   reactome:R-HSA-164381 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP";   reactome:R-HSA-165055 "Hydrolysis of Ran:GTP to Ran:GDP";   reactome:R-HSA-167415 "G-protein alpha subunit is inactivated";   reactome:R-HSA-170666 "Adenylate cyclase increases the GTPase activity of G alpha-olf";   reactome:R-HSA-170685 "Adenylaye cyclase increases the GTPase activity of G alpha-olf";   reactome:R-HSA-170686 "Adenylate cyclase increases the GTPase activity of Gi alpha";   reactome:R-HSA-177501 "Endocytosis (internalization) of clathrin-coated vesicle";   reactome:R-HSA-203973 "Vesicle budding";   reactome:R-HSA-2130641 "Translocation of TGN-lysosome vesicle to lysosome";   reactome:R-HSA-2130725 "Internalization of MHC II:Ii clathrin coated vesicle";   reactome:R-HSA-2584246 "GNAT1-GTP hydrolyses its bound GTP to GDP";   reactome:R-HSA-380979 "RHEB in mTORC1:RHEB:GTP hydrolyses GTP";   reactome:R-HSA-392133 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP";   reactome:R-HSA-392212 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP";   reactome:R-HSA-418574 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP";   reactome:R-HSA-418582 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP";   reactome:R-HSA-421835 "trans-Golgi Network Vesicle Scission";   reactome:R-HSA-428941 "P2Y purinoceptor 1 activates MAP kinase p38 alpha";   reactome:R-HSA-432707 "trans-Golgi Network Lysosomal Vesicle Scission";   reactome:R-HSA-5333615 "80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC";   reactome:R-HSA-5389839 "39S subunit binds 28S subunit:mRNA:fMet-tRNA";   reactome:R-HSA-5389842 "TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome";   reactome:R-HSA-5419273 "Hydrolysis of GTP and dissociation of 28S and 39S subunits";   reactome:R-HSA-5419279 "Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)";   reactome:R-HSA-555065 "Formation of clathrin coated vesicle";   reactome:R-HSA-5623513 "ASAP1 stimulates GTPase activity of ARF4";   reactome:R-HSA-5638006 "ARL3 hydrolyzes GTP";   reactome:R-HSA-5658231 "RAS GAPs stimulate RAS GTPase activity";   reactome:R-HSA-5665809 "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments";   reactome:R-HSA-5672017 "Rheb in the mTORC1 complex hydrolyses GTP";   reactome:R-HSA-5694527 "Loss of SAR1B GTPase";   reactome:R-HSA-6807877 "ARFGAPs stimulate ARF GTPase activity";   reactome:R-HSA-6814833 "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP";   reactome:R-HSA-8847534 "RAB43 hydrolyses GTP";   reactome:R-HSA-8847883 "CYTH proteins stimulate ARF1 GTPase activity";   reactome:R-HSA-8849082 "ARHGAP35 stimulates RHOA GTPase activity";   reactome:R-HSA-8854173 "TBC RabGAPs accelerate GTP hydrolysis by RAB35";   reactome:R-HSA-8854255 "TBC1D2A accelerates GTP hydrolysis by RAB7";   reactome:R-HSA-8854329 "TBC1D15 accelerates GTP hydrolysis by RAB7";   reactome:R-HSA-8854604 "TBC1D16 accelerates GTP hydrolysis by RAB4A";   reactome:R-HSA-8854612 "TBC1D25 accelerates GTP hydrolysis by RAB33B";   reactome:R-HSA-8868661 "Dynamin-mediated GTP hydrolysis promotes vesicle scission";   reactome:R-HSA-8981353 "RASA1 stimulates RAS GTPase activity";   reactome:R-HSA-8982020 "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated";   reactome:R-HSA-8982021 "G alpha (z) in G alpha (z):RGS complex is inactivated";   reactome:R-HSA-8982025 "G alpha (q) in G (q):RGS complex is inactivated";   reactome:R-HSA-983422 "Disassembly of COPII coated vesicle"

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GTPase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abce1 ATP binding cassette subfamily E member 1 enables ISO (PMID:20122402) UniProt PMID:20122402 NCBI chrNW_004955428:1,029,909...1,058,902
Ensembl chrNW_004955428:1,029,399...1,058,902 		JBrowse link
G Adss1 adenylosuccinate synthase 1 ISO RGD PMID:3542024 RGD:5135521 NCBI chrNW_004955538:3,179,299...3,196,251
Ensembl chrNW_004955538:3,179,299...3,196,251 		JBrowse link
G Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 enables ISO (PMID:11136977), (PMID:12640130) MGI PMID:11136977 PMID:12640130 NCBI chrNW_004955458:5,436,544...5,448,201
Ensembl chrNW_004955458:5,436,630...5,448,057 		JBrowse link
G Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 enables ISO (PMID:16461359) MGI PMID:16461359 NCBI chrNW_004955491:5,546,097...5,573,866
Ensembl chrNW_004955491:5,523,969...5,573,387 		JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta enables ISO (PMID:24554735) CACAO PMID:24554735 NCBI chrNW_004955413:11,670,889...11,688,357
Ensembl chrNW_004955413:11,670,687...11,688,611 		JBrowse link
G Arl1 ADP ribosylation factor like GTPase 1 enables ISO (PMID:8798635), (PMID:9624189) UniProt PMID:8798635 PMID:9624189 NCBI chrNW_004955405:36,913,011...36,932,383
Ensembl chrNW_004955405:36,913,011...36,918,017 		JBrowse link
G Arl2 ADP ribosylation factor like GTPase 2 enables ISO (PMID:10831612) UniProt PMID:10831612 NCBI chrNW_004955422:20,166,956...20,172,954
Ensembl chrNW_004955422:20,166,956...20,172,950 		JBrowse link
G Arl3 ADP ribosylation factor like GTPase 3 enables ISO (MGI:1928255|PMID:10518933), (MGI:4943386|PMID:18376416) UniProt PMID:10518933 PMID:18376416 MGI:1928255 MGI:4943386 NCBI chrNW_004955485:7,739,556...7,772,582
Ensembl chrNW_004955485:7,733,211...7,775,687 		JBrowse link
G Atl1 atlastin GTPase 1 enables ISO (PMID:14506257)
PMID:16537571		 UniProt PMID:14506257 PMID:16537571 RGD:8553504 NCBI chrNW_004955409:12,222,591...12,301,990
Ensembl chrNW_004955409:12,222,591...12,301,990 		JBrowse link
G Cdc42 cell division cycle 42 enables ISO (PMID:19787194), (PMID:27917469)
(PMID:10699171), (PMID:15249579), (PMID:18838382)
(PMID:18838382)		 MGI PMID:10699171 PMID:15249579 PMID:18838382 PMID:19787194 PMID:27917469 NCBI chrNW_004955452:2,255,940...2,299,042
Ensembl chrNW_004955452:2,255,117...2,299,042 		JBrowse link
G Cplane2 ciliogenesis and planar polarity effector complex subunit 2 enables ISO (PMID:29038301) MGI PMID:29038301 NCBI chrNW_004955527:2,060,063...2,064,152
Ensembl chrNW_004955527:2,060,063...2,064,152 		JBrowse link
G Cracr2a calcium release activated channel regulator 2A enables ISO (PMID:27016526) UniProt PMID:27016526 NCBI chrNW_004955413:1,425,165...1,544,226
Ensembl chrNW_004955413:1,429,021...1,543,662 		JBrowse link
G Ddx3x DEAD-box helicase 3 X-linked enables ISO (PMID:10074132) AgBase PMID:10074132 NCBI chrNW_004955565:1,387,043...1,403,624
Ensembl chrNW_004955565:1,386,973...1,404,220 		JBrowse link
G Diras1 DIRAS family GTPase 1 enables ISO (PMID:12194967) UniProt PMID:12194967 NCBI chrNW_004955495:5,002,803...5,005,203
Ensembl chrNW_004955495:5,004,548...5,005,144 		JBrowse link
G Dnajc27 DnaJ heat shock protein family (Hsp40) member C27 enables ISO (MGI:5571536|PMID:24746703) UniProt PMID:24746703 MGI:5571536 NCBI chrNW_004955469:7,046,671...7,078,666
Ensembl chrNW_004955469:7,044,804...7,078,666 		JBrowse link
G Dnm1 dynamin 1 enables ISO (MGI:5559669|PMID:19781630)
(PMID:20428113)		 UniProt PMID:19781630 PMID:20428113 MGI:5559669 NCBI chrNW_004955570:752,335...781,770
Ensembl chrNW_004955570:752,335...781,770 		JBrowse link
G Dnm1l dynamin 1 like enables ISO (PMID:22265414), (PMID:23530241) UniProt PMID:22265414 PMID:23530241 NCBI chrNW_004955505:3,025,742...3,081,491
Ensembl chrNW_004955505:3,023,018...3,081,680 		JBrowse link
G Dnm2 dynamin 2 enables ISO (PMID:34744632)
PMID:35620056
PMID:19605363
PMID:16325581		 RGD
UniProt		 PMID:16325581 PMID:19605363 PMID:21281588 PMID:34744632 PMID:35620056 RGD:13504769 RGD:401901208 RGD:401901236 RGD:8554402 NCBI chrNW_004955495:1,860,644...1,934,589
Ensembl chrNW_004955495:1,860,644...1,934,818 		JBrowse link
G Dnm3 dynamin 3 enables ISO PMID:17880892 UniProt PMID:17880892 RGD:8553820 NCBI chrNW_004955406:12,345,483...12,881,182
Ensembl chrNW_004955406:12,345,693...12,881,269 		JBrowse link
G Drg1 developmentally regulated GTP binding protein 1 enables ISO (PMID:23711155), (PMID:29915238) UniProt PMID:23711155 PMID:29915238 NCBI chrNW_004955455:5,588,313...5,608,091
Ensembl chrNW_004955455:5,588,313...5,610,964 		JBrowse link
G Drg2 developmentally regulated GTP binding protein 2 enables ISO (PMID:29915238) UniProt PMID:29915238 NCBI chrNW_004955478:11,193,245...11,210,917
Ensembl chrNW_004955478:11,193,245...11,210,914 		JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 enables ISO (PMID:26593721) UniProt PMID:26593721 NCBI chrNW_004955493:8,661,317...8,663,190 JBrowse link
G Eef2 eukaryotic translation elongation factor 2 enables ISO (PMID:26593721)
(PMID:22157746)		 UniProt
MGI		 PMID:22157746 PMID:26593721 NCBI chrNW_004955495:4,800,103...4,807,714
Ensembl chrNW_004955495:4,799,922...4,807,252 		JBrowse link
G Eefsec eukaryotic elongation factor, selenocysteine-tRNA specific enables ISO (PMID:27708257), (PMID:35709277)
(PMID:22992746)		 UniProt
MGI		 PMID:22992746 PMID:27708257 PMID:35709277 NCBI chrNW_004955429:15,381,257...15,598,355
Ensembl chrNW_004955429:15,380,601...15,585,866 		JBrowse link
G Efl1 elongation factor like GTPase 1 enables ISO (PMID:21536732) UniProt PMID:21536732 NCBI chrNW_004955416:12,658,177...12,789,657
Ensembl chrNW_004955416:12,655,563...12,789,731 		JBrowse link
G Eif5b eukaryotic translation initiation factor 5B enables ISO (PMID:35732735)
(PMID:10659855)		 UniProt PMID:10659855 PMID:35732735 NCBI chrNW_004955470:5,622,128...5,676,533
Ensembl chrNW_004955470:5,622,128...5,676,533 		JBrowse link
G Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 enables ISO (PMID:11278936) UniProt PMID:11278936 NCBI chrNW_004955507:5,552,788...5,594,911
Ensembl chrNW_004955507:5,552,764...5,594,911 		JBrowse link
G Gbp5 guanylate binding protein 5 enables ISO (PMID:26996307), (PMID:33876762) UniProt PMID:26996307 PMID:33876762 NCBI chrNW_004955423:4,914,430...4,926,850
Ensembl chrNW_004955423:4,917,590...4,926,007 		JBrowse link
G Gch1 GTP cyclohydrolase 1 enables ISO (PMID:2463916) UniProt PMID:2463916 NCBI chrNW_004955409:8,624,225...8,670,436
Ensembl chrNW_004955409:8,624,468...8,668,614 		JBrowse link
G Gem GTP binding protein overexpressed in skeletal muscle enables ISO (PMID:17107948) BHF-UCL PMID:17107948 NCBI chrNW_004955417:10,475,967...10,486,879
Ensembl chrNW_004955417:10,475,822...10,487,825 		JBrowse link
G Gfm1 G elongation factor mitochondrial 1 enables ISO (PMID:19716793) UniProt PMID:19716793 NCBI chrNW_004955448:9,390,576...9,432,919
Ensembl chrNW_004955448:9,390,576...9,433,404 		JBrowse link
G Gfm2 GTP dependent ribosome recycling factor mitochondrial 2 enables ISO (PMID:19716793) UniProt PMID:19716793 NCBI chrNW_004955425:25,904,020...25,942,384
Ensembl chrNW_004955425:25,904,020...25,942,376 		JBrowse link
G Gnai1 G protein subunit alpha i1 enables ISO PMID:21158412
PMID:8939752		 UniProt
CAFA		 PMID:8939752 PMID:21158412 RGD:12792995 RGD:8553612 NCBI chrNW_004955410:5,388,184...5,467,022
Ensembl chrNW_004955410:5,388,184...5,467,022 		JBrowse link
G Gnai3 G protein subunit alpha i3 enables ISO (PMID:19478087) UniProt PMID:19478087 NCBI chrNW_004955435:12,965,006...13,005,614
Ensembl chrNW_004955435:12,965,006...13,005,614 		JBrowse link
G Gnao1 G protein subunit alpha o1 enables ISO (MGI:5009199|PMID:10926822) RGD
UniProt		 PMID:10926822 PMID:20530129 MGI:5009199 RGD:7207369 NCBI chrNW_004955433:14,004,813...14,170,631
Ensembl chrNW_004955433:14,004,813...14,172,707 		JBrowse link
G Gnat1 G protein subunit alpha transducin 1 enables ISO (PMID:17881533) MGI PMID:17881533 NCBI chrNW_004955532:2,018,850...2,023,603
Ensembl chrNW_004955532:2,018,850...2,023,603 		JBrowse link
G Gnat3 G protein subunit alpha transducin 3 enables ISO (PMID:10570481) RGD
MGI		 PMID:7626029 PMID:10570481 RGD:2302152 NCBI chrNW_004955410:5,145,768...5,211,594
Ensembl chrNW_004955410:5,163,784...5,211,594 		JBrowse link
G Gnb1 G protein subunit beta 1 enables ISO (PMID:1543505) MGI PMID:1543505 NCBI chrNW_004955486:9,165,850...9,192,306
Ensembl chrNW_004955486:9,165,850...9,193,066 		JBrowse link
G Gngt2 G protein subunit gamma transducin 2 enables ISO (PMID:10570481) MGI PMID:10570481 NCBI chrNW_004955451:12,248,916...12,252,101
Ensembl chrNW_004955451:12,249,061...12,252,101 		JBrowse link
G Gspt1 G1 to S phase transition 1 enables ISO (PMID:15987998) UniProt PMID:15987998 NCBI chrNW_004955442:6,704,272...6,740,207
Ensembl chrNW_004955442:6,704,573...6,740,207 		JBrowse link
G Gspt2 G1 to S phase transition 2 enables ISO (PMID:15987998) UniProt PMID:15987998 NCBI chrNW_004955543:2,879,974...2,882,473 JBrowse link
G Gtpbp1 GTP binding protein 1 enables ISO PMID:21515746
(PMID:30108131)		 UniProt
FlyBase		 PMID:21515746 PMID:30108131 RGD:8553842 NCBI chrNW_004955413:24,823,113...24,849,522
Ensembl chrNW_004955413:24,823,113...24,852,691 		JBrowse link
G Gtpbp4 GTP binding protein 4 enables ISO (PMID:17210637) HGNC-UCL PMID:17210637 NCBI chrNW_004955492:5,594...33,558
Ensembl chrNW_004955492:5,594...34,111 		JBrowse link
G Hras HRas proto-oncogene, GTPase enables ISO (PMID:9178006)
(PMID:9230043)		 WB
CAFA		 PMID:9178006 PMID:9230043 NCBI chrNW_004955476:11,508,446...11,510,333
Ensembl chrNW_004955476:11,508,126...11,510,333 		JBrowse link
G Irgm immunity related GTPase M enables ISO (PMID:29420192)
(MGI:4354422|PMID:19620982)		 UniProt PMID:19620982 PMID:29420192 MGI:4354422 NCBI chrNW_004955408:2,338,510...2,344,566 JBrowse link
G Kras KRAS proto-oncogene, GTPase enables ISO (PMID:26037647)
(PMID:15665300)		 DisProt
MGI		 PMID:15665300 PMID:26037647 NCBI chrNW_004955413:20,298,852...20,328,756
Ensembl chrNW_004955413:20,298,824...20,328,758 		JBrowse link
G Lrrk2 leucine rich repeat kinase 2 enables ISO (PMID:21048939) BHF-UCL PMID:21048939 NCBI chrNW_004955505:84,324...216,923
Ensembl chrNW_004955505:81,796...216,923 		JBrowse link
G Lsg1 large 60S subunit nuclear export GTPase 1 enables ISO (PMID:16209721) UniProt PMID:16209721 NCBI chrNW_004955420:14,216,430...14,244,289 JBrowse link
G Mfn1 mitofusin 1 enables ISO (PMID:27920125)
(PMID:28114303)		 UniProt PMID:27920125 PMID:28114303 NCBI chrNW_004955420:8,541,547...8,596,494
Ensembl chrNW_004955420:8,541,936...8,594,437 		JBrowse link
G Mmaa metabolism of cobalamin associated A enables ISO (PMID:28497574)
(PMID:20876572), (PMID:21138732), (PMID:28943303)		 UniProt PMID:20876572 PMID:21138732 PMID:28497574 PMID:28943303 NCBI chrNW_004955428:1,465,118...1,489,332
Ensembl chrNW_004955428:1,473,898...1,489,665 		JBrowse link
G Mmut methylmalonyl-CoA mutase enables ISO (PMID:20876572) UniProt PMID:20876572 NCBI chrNW_004955411:8,363,142...8,397,839
Ensembl chrNW_004955411:8,363,142...8,399,216 		JBrowse link
G Mras muscle RAS oncogene homolog enables ISO (PMID:28289718) UniProt PMID:28289718 NCBI chrNW_004955501:615,303...670,404
Ensembl chrNW_004955501:615,303...670,782 		JBrowse link
G Mtg1 mitochondrial ribosome associated GTPase 1 enables ISO (PMID:23396448) UniProt PMID:23396448 NCBI chrNW_004955477:11,040,381...11,057,912
Ensembl chrNW_004955477:11,041,045...11,057,574 		JBrowse link
G Mtg2 mitochondrial ribosome associated GTPase 2 enables ISO (PMID:23396448) UniProt PMID:23396448 NCBI chrNW_004955528:1,838,051...1,849,331
Ensembl chrNW_004955528:1,838,051...1,847,672 		JBrowse link
G Nras NRAS proto-oncogene, GTPase enables ISO (PMID:30712867) UniProt PMID:30712867 NCBI chrNW_004955435:18,001,517...18,009,105
Ensembl chrNW_004955435:18,001,517...18,009,103 		JBrowse link
G Nuggc nuclear GTPase, germinal center associated enables ISO (PMID:19734146) UniProt PMID:19734146 NCBI chrNW_004955403:50,507,971...50,558,881
Ensembl chrNW_004955403:50,507,116...50,558,826 		JBrowse link
G Opa1 OPA1 mitochondrial dynamin like GTPase enables ISO (PMID:20185555), (PMID:27667664) UniProt PMID:20185555 PMID:27667664 NCBI chrNW_004955420:14,927,490...15,007,082
Ensembl chrNW_004955420:14,923,575...15,007,081 		JBrowse link
G Rab11a RAB11A, member RAS oncogene family enables ISO (PMID:15837192), (PMID:16905101), (PMID:17007872), (PMID:17030804), (PMID:17562788) RGD
UniProt		 PMID:15837192 PMID:16473307 PMID:16905101 PMID:17007872 PMID:17030804 More... RGD:2306439 NCBI chrNW_004955450:9,638,761...9,656,291
Ensembl chrNW_004955450:9,638,761...9,656,603 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family enables ISO (PMID:16545962)
(MGI:5486575|PMID:10942597)		 UniProt PMID:10942597 PMID:16545962 MGI:5486575 NCBI chrNW_004955563:1,008,267...1,017,315
Ensembl chrNW_004955563:1,008,769...1,017,315 		JBrowse link
G Rab13 RAB13, member RAS oncogene family enables ISO (PMID:8294494) UniProt PMID:8294494 NCBI chrNW_004955545:590,021...594,191
Ensembl chrNW_004955545:589,239...594,835 		JBrowse link
G Rab14 RAB14, member RAS oncogene family enables ISO (PMID:16034420), (PMID:17562788) UniProt PMID:16034420 PMID:17562788 NCBI chrNW_004955419:6,790,110...6,812,870
Ensembl chrNW_004955419:6,790,707...6,812,870 		JBrowse link
G Rab17 RAB17, member RAS oncogene family enables ISO (PMID:17646400) UniProt PMID:17646400 NCBI chrNW_004955542:2,751,953...2,759,661 JBrowse link
G Rab1a RAB1A, member RAS oncogene family enables ISO (PMID:17684057), (PMID:22939626) UniProt PMID:17684057 PMID:22939626 NCBI chrNW_004955424:19,393,589...19,421,373
Ensembl chrNW_004955424:19,393,589...19,421,373 		JBrowse link
G Rab21 RAB21, member RAS oncogene family enables ISO (PMID:16034420) UniProt PMID:16034420 NCBI chrNW_004955405:11,766,674...11,778,637
Ensembl chrNW_004955405:11,765,857...11,777,192 		JBrowse link
G Rab22a RAB22A, member RAS oncogene family enables ISO (PMID:24466322)
(MGI:4399023|PMID:16034420)		 UniProt PMID:16034420 PMID:24466322 MGI:4399023 NCBI chrNW_004955445:1,167,941...1,224,932
Ensembl chrNW_004955445:1,174,817...1,225,763 		JBrowse link
G Rab23 RAB23, member RAS oncogene family enables ISO (PMID:17646400), (PMID:22365972) UniProt PMID:17646400 PMID:22365972 NCBI chrNW_004955502:2,947,170...2,980,634
Ensembl chrNW_004955502:2,950,562...2,980,634 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family enables ISO (MGI:4412435|PMID:18940603) UniProt PMID:18940603 MGI:4412435 NCBI chrNW_004955409:588,725...621,874
Ensembl chrNW_004955409:588,254...621,874 		JBrowse link
G Rab27b RAB27B, member RAS oncogene family enables ISO (MGI:4412434|PMID:18940604) UniProt PMID:18940604 MGI:4412434 NCBI chrNW_004955402:39,357,500...39,415,530
Ensembl chrNW_004955402:39,357,500...39,415,530 		JBrowse link
G Rab2a RAB2A, member RAS oncogene family enables ISO (PMID:16034420), (PMID:17562788), (PMID:17684057) UniProt PMID:16034420 PMID:17562788 PMID:17684057 NCBI chrNW_004955444:18,091,640...18,169,971
Ensembl chrNW_004955444:18,091,640...18,169,971 		JBrowse link
G Rab32 RAB32, member RAS oncogene family enables ISO (PMID:21808068) UniProt PMID:21808068 NCBI chrNW_004955436:14,171,123...14,177,255
Ensembl chrNW_004955436:14,171,123...14,177,577 		JBrowse link
G Rab33b RAB33B, member RAS oncogene family enables ISO (PMID:21808068) UniProt PMID:21808068 NCBI chrNW_004955428:4,192,357...4,211,740
Ensembl chrNW_004955428:4,190,061...4,211,740 		JBrowse link
G Rab34 RAB34, member RAS oncogene family enables ISO (PMID:12446704) MGI PMID:12446704 NCBI chrNW_004955481:4,441,290...4,445,969
Ensembl chrNW_004955481:4,441,407...4,445,969 		JBrowse link
G Rab35 RAB35, member RAS oncogene family enables ISO (PMID:17562788) UniProt PMID:17562788 NCBI chrNW_004955455:11,484,557...11,502,630
Ensembl chrNW_004955455:11,484,557...11,502,630 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family enables ISO (PMID:24891604)
(PMID:10859313)		 UniProt PMID:10859313 PMID:24891604 NCBI chrNW_004955524:3,220,108...3,224,376
Ensembl chrNW_004955524:3,221,366...3,224,376 		JBrowse link
G Rab3b RAB3B, member RAS oncogene family enables ISO (PMID:24891604) UniProt PMID:24891604 NCBI chrNW_004955464:7,117,908...7,177,138
Ensembl chrNW_004955464:7,117,883...7,177,534 		JBrowse link
G Rab3c RAB3C, member RAS oncogene family enables ISO (PMID:24891604) UniProt PMID:24891604 NCBI chrNW_004955446:9,335,298...9,577,919
Ensembl chrNW_004955446:9,343,388...9,578,209 		JBrowse link
G Rab43 RAB43, member RAS oncogene family enables ISO (PMID:17562788), (PMID:24891604) UniProt PMID:17562788 PMID:24891604 NCBI chrNW_004955429:13,474,460...13,506,979
Ensembl chrNW_004955429:13,474,460...13,506,979 		JBrowse link
G Rab4a RAB4A, member RAS oncogene family enables ISO (PMID:15907487), (PMID:16034420), (PMID:17562788) RGD
UniProt		 PMID:9169411 PMID:11063739 PMID:15907487 PMID:16034420 PMID:17562788 RGD:2306283 RGD:2306443 NCBI chrNW_004955492:8,715,252...8,743,432
Ensembl chrNW_004955492:8,713,968...8,743,434 		JBrowse link
G Rab5a RAB5A, member RAS oncogene family enables ISO (PMID:15378032), (PMID:17562788), (PMID:24891604)
(PMID:12446704)		 UniProt
MGI		 PMID:12446704 PMID:15378032 PMID:17562788 PMID:24891604 NCBI chrNW_004955430:11,991,548...12,040,003 JBrowse link
G Rab5b RAB5B, member RAS oncogene family enables ISO (PMID:17562788) UniProt PMID:17562788 NCBI chrNW_004955458:3,563,363...3,582,620
Ensembl chrNW_004955458:3,576,247...3,580,192 		JBrowse link
G Rab5c RAB5C, member RAS oncogene family enables ISO (PMID:17562788) UniProt PMID:17562788 NCBI chrNW_004955451:16,200,442...16,215,583
Ensembl chrNW_004955451:16,200,442...16,215,583 		JBrowse link
G Rab6a RAB6A, member RAS oncogene family enables ISO (PMID:16332443), (PMID:18243103) UniProt PMID:16332443 PMID:18243103 NCBI chrNW_004955414:17,758,071...17,806,727
Ensembl chrNW_004955414:17,758,071...17,806,727 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family enables ISO (PMID:18272684) BHF-UCL PMID:18272684 NCBI chrNW_004955429:15,103,792...15,167,498 JBrowse link
G Rab8a RAB8A, member RAS oncogene family enables ISO (PMID:17646400) UniProt PMID:17646400 NCBI chrNW_004955524:1,403,811...1,416,005
Ensembl chrNW_004955524:1,403,811...1,416,005 		JBrowse link
G Rab9a RAB9A, member RAS oncogene family enables ISO (PMID:15263003) UniProt PMID:15263003 NCBI chrNW_004955519:4,489,159...4,496,089
Ensembl chrNW_004955519:4,489,159...4,496,089 		JBrowse link
G Rac1 Rac family small GTPase 1 enables ISO (PMID:10699171), (PMID:12525493), (PMID:15249579)
(PMID:19787194), (PMID:27917469)		 RGD
MGI		 PMID:10699171 PMID:12525493 PMID:12672819 PMID:15249579 PMID:19787194 More... RGD:704329 NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351 		JBrowse link
G Rac2 Rac family small GTPase 2 enables ISO (PMID:15249579) MGI PMID:15249579 NCBI chrNW_004955413:23,697,504...23,710,668
Ensembl chrNW_004955413:23,693,669...23,710,704 		JBrowse link
G Rac3 Rac family small GTPase 3 enables ISO (PMID:11956649) UniProt PMID:11956649 NCBI chrNW_004955506:1,139,098...1,142,443
Ensembl chrNW_004955506:1,137,204...1,141,336 		JBrowse link
G Rala RAS like proto-oncogene A enables ISO (MGI:5317053|PMID:21148297), (MGI:5770072|PMID:17765682)
(PMID:30500825)		 Reactome
UniProt		 PMID:17765682 PMID:21148297 PMID:30500825 MGI:5317053 MGI:5770072 NCBI chrNW_004955460:3,789,136...3,853,315
Ensembl chrNW_004955460:3,789,136...3,808,676 		JBrowse link
G Ralb RAS like proto-oncogene B enables ISO (PMID:19166349) UniProt PMID:19166349 NCBI chrNW_004955459:9,533,081...9,574,464
Ensembl chrNW_004955459:9,531,538...9,574,766 		JBrowse link
G Ran RAN, member RAS oncogene family enables ISO (PMID:26272610), (PMID:8636225) UniProt PMID:8636225 PMID:26272610 NCBI chrNW_004955482:1,222,944...1,223,891
Ensembl chrNW_004955482:1,220,876...1,224,395 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family enables ISO (PMID:12473665) MGI PMID:12473665 NCBI chrNW_004955435:15,090,521...15,171,397
Ensembl chrNW_004955435:15,150,827...15,171,397 		JBrowse link
G Rap1b RAP1B, member of RAS oncogene family enables ISO (PMID:18309292) UniProt PMID:18309292 NCBI chrNW_004955458:15,110,709...15,121,868
Ensembl chrNW_004955458:15,080,778...15,123,203 		JBrowse link
G Rap2a RAP2A, member of RAS oncogene family enables ISO (PMID:1900290) UniProt PMID:1900290 NCBI chrNW_004955404:12,897,518...12,936,964
Ensembl chrNW_004955404:12,897,240...12,936,964 		JBrowse link
G Rem2 RRAD and GEM like GTPase 2 ISO RGD PMID:10727423 RGD:68879 NCBI chrNW_004955409:37,403,758...37,408,312
Ensembl chrNW_004955409:37,402,212...37,408,312 		JBrowse link
G Rerg RAS like estrogen regulated growth inhibitor enables ISO (PMID:11533059) UniProt PMID:11533059 NCBI chrNW_004955413:11,825,235...11,940,390
Ensembl chrNW_004955413:11,825,235...11,940,804 		JBrowse link
G Rheb Ras homolog, mTORC1 binding enables ISO (PMID:15340059), (PMID:22819219), (PMID:29416044), (PMID:32470140) RGD
UniProt		 PMID:15340059 PMID:16354680 PMID:22819219 PMID:29416044 PMID:32470140 RGD:1625606 NCBI chrNW_004955491:5,795,040...5,833,897
Ensembl chrNW_004955491:5,794,911...5,834,912 		JBrowse link
G Rhoa ras homolog family member A enables ISO (PMID:18829532)
(PMID:10699171), (PMID:15249579), (PMID:15798203)
PMID:21440892
(PMID:19734146), (PMID:19787194), (PMID:26529257), (PMID:27917469)		 Reactome
MGI
BHF-UCL
UniProt		 PMID:10699171 PMID:15249579 PMID:15798203 PMID:18829532 PMID:19734146 More... RGD:7248703 NCBI chrNW_004955532:1,300,821...1,347,453
Ensembl chrNW_004955532:1,300,462...1,347,451 		JBrowse link
G Rhog ras homolog family member G enables ISO (PMID:12376551) MGI PMID:12376551 NCBI chrNW_004955414:19,630,564...19,641,722
Ensembl chrNW_004955414:19,630,564...19,641,550 		JBrowse link
G Rhoj ras homolog family member J enables ISO (PMID:27660391) UniProt PMID:27660391 NCBI chrNW_004955466:6,476,822...6,564,890
Ensembl chrNW_004955466:6,476,822...6,564,988 		JBrowse link
G Rhoq ras homolog family member Q enables ISO (PMID:10445846) BHF-UCL PMID:10445846 NCBI chrNW_004955441:13,457,757...13,495,221
Ensembl chrNW_004955441:13,457,757...13,495,221 		JBrowse link
G Rhou ras homolog family member U enables ISO (PMID:11459829) MGI PMID:11459829 NCBI chrNW_004955492:8,949,003...8,955,502
Ensembl chrNW_004955492:8,949,008...8,955,502 		JBrowse link
G Rit1 Ras like without CAAX 1 enables ISO (PMID:10545207) ParkinsonsUK-UCL PMID:10545207 NCBI chrNW_004955545:2,089,530...2,099,404
Ensembl chrNW_004955545:2,089,536...2,099,404 		JBrowse link
G Rit2 Ras like without CAAX 2 enables ISO (MGI:4456963|PMID:10545207) ParkinsonsUK-UCL PMID:10545207 MGI:4456963 NCBI chrNW_004955402:28,737,882...29,137,006
Ensembl chrNW_004955402:28,737,575...29,078,777 		JBrowse link
G Rnf112 ring finger protein 112 enables ISO (MGI:5779470|PMID:26212327) UniProt PMID:26212327 MGI:5779470 NCBI chrNW_004955467:349,703...355,922
Ensembl chrNW_004955467:349,256...355,922 		JBrowse link
G Rraga Ras related GTP binding A enables ISO (PMID:23723238), (PMID:31601708), (PMID:31601764)
(MGI:5473730|PMID:23263183)		 UniProt PMID:23263183 PMID:23723238 PMID:31601708 PMID:31601764 MGI:5473730 NCBI chrNW_004955434:21,509,528...21,510,885
Ensembl chrNW_004955434:21,509,529...21,510,470 		JBrowse link
G Rragb Ras related GTP binding B enables ISO (PMID:23723238) SGD PMID:23723238 NCBI chrNW_004955475:2,662,969...2,692,253
Ensembl chrNW_004955475:2,662,868...2,696,364 		JBrowse link
G Rragc Ras related GTP binding C enables ISO (PMID:11073942), (PMID:23723238), (PMID:31601708), (PMID:31601764) UniProt PMID:11073942 PMID:23723238 PMID:31601708 PMID:31601764 NCBI chrNW_004955452:16,469,426...16,486,336
Ensembl chrNW_004955452:16,466,453...16,486,336 		JBrowse link
G Rragd Ras related GTP binding D enables ISO (PMID:22424946) CAFA PMID:22424946 NCBI chrNW_004955411:16,111,931...16,155,662
Ensembl chrNW_004955411:16,114,755...16,138,433 		JBrowse link
G Rras RAS related enables ISO (PMID:24705357)
(PMID:16773572)		 UniProt PMID:16773572 PMID:24705357 NCBI chrNW_004955559:1,244,658...1,248,774
Ensembl chrNW_004955559:1,244,658...1,248,774 		JBrowse link
G Rras2 RAS related 2 enables ISO (PMID:31130282) UniProt PMID:31130282 NCBI chrNW_004955414:29,482,502...29,546,102
Ensembl chrNW_004955414:29,481,343...29,493,070 		JBrowse link
G Septin4 septin 4 enables ISO (PMID:17105210) CAFA PMID:17105210 NCBI chrNW_004955451:4,505,318...4,530,387 JBrowse link
G Srp54 signal recognition particle 54 contributes_to
enables		 ISO (PMID:8247130)
(PMID:28972538)		 UniProtKB
UniProt		 PMID:8247130 PMID:28972538 NCBI chrNW_004955409:25,977,226...26,016,351
Ensembl chrNW_004955409:25,977,226...26,016,351 		JBrowse link
G Tbcc tubulin folding cofactor C enables ISO (PMID:11847227) UniProt PMID:11847227 NCBI chrNW_004955437:8,808,021...8,809,598 JBrowse link
G Trim23 tripartite motif containing 23 enables ISO (PMID:8700863) HGNC-UCL PMID:8700863 NCBI chrNW_004955446:3,480,177...3,509,050
Ensembl chrNW_004955446:3,479,858...3,509,050 		JBrowse link
G Zng1a Zn regulated GTPase metalloprotein activator 1A enables ISO (PMID:35584702) UniProt PMID:35584702 NCBI chrNW_004955434:4,732,584...4,780,990 JBrowse link
G protein activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arf6 ADP ribosylation factor 6 enables ISO (PMID:32103017) UniProt PMID:32103017 NCBI chrNW_004955409:12,814,814...12,818,142
Ensembl chrNW_004955409:12,817,496...12,818,023 		JBrowse link
G Arl8b ADP ribosylation factor like GTPase 8B enables ISO (PMID:16537643) UniProt PMID:16537643 NCBI chrNW_004955421:8,231,337...8,276,907
Ensembl chrNW_004955421:8,231,582...8,276,907 		JBrowse link
G Gna11 G protein subunit alpha 11 enables ISO (PMID:26075576) MGI PMID:26075576 NCBI chrNW_004955495:5,286,891...5,302,631
Ensembl chrNW_004955495:5,285,380...5,302,631 		JBrowse link
G Gnaq G protein subunit alpha q enables ISO (PMID:26075576) MGI PMID:26075576 NCBI chrNW_004955512:1,381,159...1,658,409 JBrowse link
G Irgm immunity related GTPase M enables ISO (PMID:30612879) UniProt PMID:30612879 NCBI chrNW_004955408:2,338,510...2,344,566 JBrowse link
G Rac1 Rac family small GTPase 1 enables ISO (PMID:17058265), (PMID:35676269)
(PMID:35263589)		 MGI
UniProt		 PMID:17058265 PMID:35263589 PMID:35676269 NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351 		JBrowse link
G Ran RAN, member RAS oncogene family enables ISO (PMID:11336674) UniProt PMID:11336674 NCBI chrNW_004955482:1,222,944...1,223,891
Ensembl chrNW_004955482:1,220,876...1,224,395 		JBrowse link
G Rap1b RAP1B, member of RAS oncogene family enables ISO (PMID:11056535) MGI PMID:11056535 NCBI chrNW_004955458:15,110,709...15,121,868
Ensembl chrNW_004955458:15,080,778...15,123,203 		JBrowse link
G Sar1a secretion associated Ras related GTPase 1A enables ISO (PMID:32358066) UniProt PMID:32358066 NCBI chrNW_004955437:21,075,632...21,093,608
Ensembl chrNW_004955437:21,074,930...21,093,608 		JBrowse link
G Sar1b secretion associated Ras related GTPase 1B enables ISO (PMID:32358066) UniProt PMID:32358066 NCBI chrNW_004955408:5,737,197...5,761,228 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14206
    catalytic activity 3710
      hydrolase activity 1331
        hydrolase activity, acting on acid anhydrides 284
          hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 284
            pyrophosphatase activity 284
              ribonucleoside triphosphate phosphatase activity 237
                GTPase activity 122
                  G protein activity 10
                  GTPase motor activity + 0
paths to the root