Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
go back to main search page
Accession:GO:0003918 term browser browse the term
Definition:Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
Synonyms:exact_synonym: deoxyribonucleic topoisomerase activity
 narrow_synonym: DNA topoisomerase II activity;   DNA topoisomerase IV activity
 broad_synonym: deoxyribonucleate topoisomerase;   topoisomerase
 related_synonym: DNA topoisomerase (ATP-hydrolysing);   DNA topoisomerase II;   DNA topoisomerase type II activity;   topoisomerase II
 alt_id: GO:0061505
 xref: EC:5.6.2.2;   MetaCyc:5.99.1.3-RXN;   Wikipedia:Type_II_topoisomerase



show annotations for term's descendants           Sort by:
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spo11 SPO11 initiator of meiotic double strand breaks enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:161,755,299...161,770,930
Ensembl chr 3:161,757,519...161,770,925
JBrowse link
G Top2a DNA topoisomerase II alpha enables IDA
ISO
IEA
(PMID:12711669), (PMID:16611985)
GO_REF:0000117
SGD:S000005032 (PMID:1331984), (PMID:7842491), (PMID:7937150), (PMID:9094096)
RGD
UniProt
PMID:1331984 PMID:7842491 PMID:7937150 PMID:9094096 PMID:12711669 More... GO_REF:0000117, RGD:1580614 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Top2b DNA topoisomerase II beta enables ISO (PMID:10684600), (PMID:31409799), (PMID:32128574)
(PMID:31409799)
RGD PMID:10684600 PMID:31409799 PMID:32128574 NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085
JBrowse link
DNA negative supercoiling activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Top2a DNA topoisomerase II alpha enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20623
    ATP-dependent activity 629
      ATP-dependent activity, acting on DNA 153
        DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity 3
          DNA negative supercoiling activity 1
Path 2
Term Annotations click to browse term
  molecular_function 20623
    catalytic activity 6029
      catalytic activity, acting on a nucleic acid 650
        catalytic activity, acting on DNA 284
          DNA topoisomerase activity 7
            DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity 3
              DNA negative supercoiling activity 1
paths to the root