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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
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Accession:GO:0003918 term browser browse the term
Definition:Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
Synonyms:exact_synonym: deoxyribonucleic topoisomerase activity
 narrow_synonym: DNA topoisomerase II activity;   DNA topoisomerase IV activity
 broad_synonym: deoxyribonucleate topoisomerase;   topoisomerase
 related_synonym: DNA topoisomerase (ATP-hydrolysing);   DNA topoisomerase II;   DNA topoisomerase type II activity;   topoisomerase II
 alt_id: GO:0061505
 xref: EC:5.6.2.2;   MetaCyc:5.99.1.3-RXN;   Wikipedia:Type_II_topoisomerase


show annotations for term's descendants           Sort by:
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SPO11 SPO11 initiator of meiotic double strand breaks enables IEA InterPro GO_REF:0000002 NCBI chr17:57,730,676...57,745,875
Ensembl chr17:57,730,675...57,745,875 		JBrowse link
G TOP2A DNA topoisomerase II alpha enables ISO
IEA
ISS		 RGD
Ensembl
UniProt
InterPro		 PMID:11334111 GO_REF:0000002 GO_REF:0000024 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117 RGD:1580614 NCBI chr12:22,001,300...22,028,452
Ensembl chr12:22,001,282...22,028,450 		JBrowse link
G TOP2B DNA topoisomerase II beta enables IEA UniProt
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117 NCBI chr13:12,507,738...12,575,042
Ensembl chr13:12,507,138...12,575,583 		JBrowse link
DNA negative supercoiling activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TOP2A DNA topoisomerase II alpha enables IEA UniProt GO_REF:0000003 NCBI chr12:22,001,300...22,028,452
Ensembl chr12:22,001,282...22,028,450 		JBrowse link
G TOP2B DNA topoisomerase II beta enables IEA UniProt GO_REF:0000003 NCBI chr13:12,507,738...12,575,042
Ensembl chr13:12,507,138...12,575,583 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18634
    ATP-dependent activity 598
      ATP-dependent activity, acting on DNA 131
        DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity 3
          DNA negative supercoiling activity 2
Path 2
Term Annotations click to browse term
  molecular_function 18634
    catalytic activity 5562
      catalytic activity, acting on a nucleic acid 606
        catalytic activity, acting on DNA 253
          DNA topoisomerase activity 7
            DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity 3
              DNA negative supercoiling activity 2
paths to the root