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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
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Accession:GO:0003918 term browser browse the term
Definition:Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
Synonyms:exact_synonym: deoxyribonucleic topoisomerase activity
 narrow_synonym: DNA topoisomerase II activity;   DNA topoisomerase IV activity
 broad_synonym: deoxyribonucleate topoisomerase;   topoisomerase
 related_synonym: DNA topoisomerase (ATP-hydrolysing);   DNA topoisomerase II;   DNA topoisomerase type II activity;   topoisomerase II
 alt_id: GO:0061505
 xref: EC:5.6.2.2;   MetaCyc:5.99.1.3-RXN;   Wikipedia:Type_II_topoisomerase

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DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101702367 DNA topoisomerase 2-alpha enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000117 NCBI chrNW_004624795:2,903,686...2,927,028
Ensembl chrNW_004624795:2,898,038...2,926,049 		JBrowse link
G Spo11 SPO11 initiator of meiotic double strand breaks enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624741:23,784,362...23,800,127
Ensembl chrNW_004624741:23,784,298...23,800,168 		JBrowse link
G Top2b DNA topoisomerase II beta enables IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000117 NCBI chrNW_004624788:3,493,188...3,590,138 JBrowse link
DNA negative supercoiling activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101702367 DNA topoisomerase 2-alpha enables IEA UniProt GO_REF:0000003 NCBI chrNW_004624795:2,903,686...2,927,028
Ensembl chrNW_004624795:2,898,038...2,926,049 		JBrowse link
G Top2b DNA topoisomerase II beta enables IEA UniProt GO_REF:0000003 NCBI chrNW_004624788:3,493,188...3,590,138 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 16462
    ATP-dependent activity 546
      ATP-dependent activity, acting on DNA 116
        DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity 3
          DNA negative supercoiling activity 2
Path 2
Term Annotations click to browse term
  molecular_function 16462
    catalytic activity 5198
      catalytic activity, acting on a nucleic acid 576
        catalytic activity, acting on DNA 233
          DNA topoisomerase activity 6
            DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity 3
              DNA negative supercoiling activity 2
paths to the root