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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
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Accession:GO:0003918 term browser browse the term
Definition:Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
Synonyms:exact_synonym: deoxyribonucleic topoisomerase activity
 narrow_synonym: DNA topoisomerase II activity;   DNA topoisomerase IV activity
 broad_synonym: deoxyribonucleate topoisomerase;   topoisomerase
 related_synonym: DNA topoisomerase (ATP-hydrolysing);   DNA topoisomerase II;   DNA topoisomerase type II activity;   topoisomerase II
 alt_id: GO:0061505
 xref: EC:5.6.2.2;   MetaCyc:5.99.1.3-RXN;   Wikipedia:Type_II_topoisomerase


show annotations for term's descendants           Sort by:
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SPO11 SPO11 initiator of meiotic double strand breaks enables IEA InterPro GO_REF:0000002 NCBI chr20:57,329,803...57,343,993
Ensembl chr20:57,329,803...57,343,994 		JBrowse link
G TOP2A DNA topoisomerase II alpha enables ISO
IEA
IMP
IDA		 (PMID:12711669)
(PMID:16611985)		 RGD
UniProt
Ensembl
InterPro		 PMID:11334111 PMID:12711669 PMID:16611985 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117 RGD:1580614 NCBI chr17:40,388,525...40,417,896
Ensembl chr17:40,388,525...40,417,896 		JBrowse link
G TOP2B DNA topoisomerase II beta enables IDA
IEA
IMP		 (PMID:10684600)
(PMID:31409799), (PMID:32128574)		 UniProt
InterPro
Ensembl		 PMID:10684600 PMID:31409799 PMID:32128574 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000117 NCBI chr 3:25,597,905...25,664,907
Ensembl chr 3:25,597,978...25,664,909 		JBrowse link
DNA negative supercoiling activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SPO11 SPO11 initiator of meiotic double strand breaks enables IEA UniProt GO_REF:0000003 NCBI chr20:57,329,803...57,343,993
Ensembl chr20:57,329,803...57,343,994 		JBrowse link
G TOP2A DNA topoisomerase II alpha enables IEA UniProt GO_REF:0000003 NCBI chr17:40,388,525...40,417,896
Ensembl chr17:40,388,525...40,417,896 		JBrowse link
G TOP2B DNA topoisomerase II beta enables IEA UniProt GO_REF:0000003 NCBI chr 3:25,597,905...25,664,907
Ensembl chr 3:25,597,978...25,664,909 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19524
    ATP-dependent activity 618
      ATP-dependent activity, acting on DNA 217
        DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity 3
          DNA negative supercoiling activity 3
Path 2
Term Annotations click to browse term
  molecular_function 19524
    catalytic activity 6003
      catalytic activity, acting on a nucleic acid 683
        catalytic activity, acting on DNA 354
          DNA topoisomerase activity 7
            DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity 3
              DNA negative supercoiling activity 3
paths to the root