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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA topoisomerase type I (single strand cut, ATP-independent) activity
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Accession:GO:0003917 term browser browse the term
Definition:Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
Comment:Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity.
Synonyms:exact_synonym: type I DNA topoisomerase activity;   type I topoisomerase activity
 narrow_synonym: DNA topoisomerase I activity
 broad_synonym: deoxyribonucleate topoisomerase;   topoisomerase
 related_synonym: nicking-closing enzyme activity;   omega-protein activity;   relaxing enzyme activity;   swivelase activity;   untwisting enzyme activity
 xref: EC:5.6.2.1;   MetaCyc:5.99.1.2-RXN


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DNA topoisomerase type I (single strand cut, ATP-independent) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TOP1 DNA topoisomerase I enables ISO
IBA
IMP
IEA
IDA		 (PMID:14654701), (PMID:17355975), (PMID:8567649), (PMID:8631793), (PMID:8631794), (PMID:9611241)
(PMID:14594810)		 RGD
GO_Central
CAFA
InterPro
Ensembl
UniProt		 PMID:1332866 PMID:8567649 PMID:8631793 PMID:8631794 PMID:9611241 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 RGD:1580856 NCBI chr20:41,028,822...41,124,487
Ensembl chr20:41,028,822...41,124,487 		JBrowse link
G TOP1MT DNA topoisomerase I mitochondrial enables IEA
IBA		 InterPro
UniProt
GO_Central		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 NCBI chr 8:143,309,324...143,359,977
Ensembl chr 8:143,304,384...143,359,979 		JBrowse link
G TOP3A DNA topoisomerase III alpha enables IEA
IBA
IDA		 (PMID:20445207) InterPro
GO_Central
UniProt		 PMID:20445207 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 NCBI chr17:18,271,428...18,314,994
Ensembl chr17:18,271,428...18,315,007 		JBrowse link
G TOP3B DNA topoisomerase III beta enables IEA
IBA		 InterPro
GO_Central
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 NCBI chr22:21,957,025...21,982,787
Ensembl chr22:21,957,025...21,982,813 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19524
    catalytic activity 6003
      isomerase activity 203
        DNA topoisomerase activity 7
          DNA topoisomerase type I (single strand cut, ATP-independent) activity 4
Path 2
Term Annotations click to browse term
  molecular_function 19524
    catalytic activity 6003
      catalytic activity, acting on a nucleic acid 683
        catalytic activity, acting on DNA 354
          DNA topoisomerase activity 7
            DNA topoisomerase type I (single strand cut, ATP-independent) activity 4
paths to the root