Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:DNA topoisomerase type I (single strand cut, ATP-independent) activity
go back to main search page
Accession:GO:0003917 term browser browse the term
Definition:Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
Comment:Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity.
Synonyms:exact_synonym: type I DNA topoisomerase activity;   type I topoisomerase activity
 narrow_synonym: DNA topoisomerase I activity
 broad_synonym: deoxyribonucleate topoisomerase;   topoisomerase
 related_synonym: nicking-closing enzyme activity;   omega-protein activity;   relaxing enzyme activity;   swivelase activity;   untwisting enzyme activity
 xref: EC:5.6.2.1;   MetaCyc:5.99.1.2-RXN

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
DNA topoisomerase type I (single strand cut, ATP-independent) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC103237562 DNA topoisomerase I mitochondrial enables IEA UniProt
InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000118 NCBI chr 8:137,523,739...137,574,672
Ensembl chr 8:137,523,955...137,552,407 		JBrowse link
G TOP1 DNA topoisomerase I enables ISO
IEA		 RGD
UniProt
Ensembl
InterPro
TreeGrafter		 PMID:1332866 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1580856 NCBI chr 2:22,655,085...22,751,082
Ensembl chr 2:22,651,995...22,751,102 		JBrowse link
G TOP3A DNA topoisomerase III alpha enables IEA InterPro
Ensembl
UniProt
TreeGrafter		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr16:17,315,466...17,358,863
Ensembl chr16:17,316,048...17,358,580 		JBrowse link
G TOP3B DNA topoisomerase III beta enables IEA InterPro
UniProt
TreeGrafter		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000118 NCBI chr19:4,137,823...4,163,860
Ensembl chr19:4,137,862...4,166,436 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18124
    catalytic activity 5456
      isomerase activity 191
        DNA topoisomerase activity 7
          DNA topoisomerase type I (single strand cut, ATP-independent) activity 4
Path 2
Term Annotations click to browse term
  molecular_function 18124
    catalytic activity 5456
      catalytic activity, acting on a nucleic acid 598
        catalytic activity, acting on DNA 252
          DNA topoisomerase activity 7
            DNA topoisomerase type I (single strand cut, ATP-independent) activity 4
paths to the root