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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA topoisomerase type I (single strand cut, ATP-independent) activity
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Accession:GO:0003917 term browser browse the term
Definition:Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.
Comment:Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity.
Synonyms:exact_synonym: type I DNA topoisomerase activity;   type I topoisomerase activity
 narrow_synonym: DNA topoisomerase I activity
 broad_synonym: deoxyribonucleate topoisomerase;   topoisomerase
 related_synonym: nicking-closing enzyme activity;   omega-protein activity;   relaxing enzyme activity;   swivelase activity;   untwisting enzyme activity
 xref: EC:5.6.2.1;   MetaCyc:5.99.1.2-RXN


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DNA topoisomerase type I (single strand cut, ATP-independent) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TOP1 DNA topoisomerase I enables ISO
IEA		 RGD
TreeGrafter
Ensembl
UniProt
InterPro		 PMID:1332866 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1580856 NCBI chr20:37,368,606...37,464,649
Ensembl chr20:38,468,452...38,562,652 		JBrowse link
G TOP1MT DNA topoisomerase I mitochondrial enables IEA UniProt
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000118 NCBI chr 8:140,056,468...140,106,510 JBrowse link
G TOP3A DNA topoisomerase III alpha enables IEA InterPro
UniProt
Ensembl
TreeGrafter		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr17:32,814,448...32,858,076
Ensembl chr17:37,897,037...37,936,135 		JBrowse link
G TOP3B DNA topoisomerase III beta enables IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000118 NCBI chr22:4,076,295...4,102,086
Ensembl chr22:20,557,248...20,583,464 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17686
    catalytic activity 5353
      isomerase activity 176
        DNA topoisomerase activity 7
          DNA topoisomerase type I (single strand cut, ATP-independent) activity 4
Path 2
Term Annotations click to browse term
  molecular_function 17686
    catalytic activity 5353
      catalytic activity, acting on a nucleic acid 602
        catalytic activity, acting on DNA 254
          DNA topoisomerase activity 7
            DNA topoisomerase type I (single strand cut, ATP-independent) activity 4
paths to the root