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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA topoisomerase activity
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Accession:GO:0003916 term browser browse the term
Definition:Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
Synonyms:alt_id: GO:0009387


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DNA topoisomerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101702367 DNA topoisomerase 2-alpha enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624795:2,903,686...2,927,028
Ensembl chrNW_004624795:2,898,038...2,926,049
JBrowse link
G Spo11 SPO11 initiator of meiotic double strand breaks enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624741:23,784,362...23,800,127
Ensembl chrNW_004624741:23,784,298...23,800,168
JBrowse link
G Top1 DNA topoisomerase I enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624919:1,668,712...1,756,624
Ensembl chrNW_004624919:1,668,440...1,756,629
JBrowse link
G Top2b DNA topoisomerase II beta enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624788:3,493,188...3,590,138 JBrowse link
G Top3a DNA topoisomerase III alpha enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624849:3,159,432...3,196,235
Ensembl chrNW_004624849:3,159,810...3,194,860
JBrowse link
G Top3b DNA topoisomerase III beta enables IEA UniProt GO_REF:0000043 NCBI chrNW_004624747:1,450,236...1,473,467
Ensembl chrNW_004624747:1,446,412...1,473,600
JBrowse link
DNA negative supercoiling activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101702367 DNA topoisomerase 2-alpha enables IEA UniProt GO_REF:0000003 NCBI chrNW_004624795:2,903,686...2,927,028
Ensembl chrNW_004624795:2,898,038...2,926,049
JBrowse link
G Top2b DNA topoisomerase II beta enables IEA UniProt GO_REF:0000003 NCBI chrNW_004624788:3,493,188...3,590,138 JBrowse link
DNA topoisomerase type I (single strand cut, ATP-independent) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Top1 DNA topoisomerase I enables ISO
IEA
RGD
UniProt
InterPro
TreeGrafter
PMID:1332866 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000118 RGD:1580856 NCBI chrNW_004624919:1,668,712...1,756,624
Ensembl chrNW_004624919:1,668,440...1,756,629
JBrowse link
G Top3a DNA topoisomerase III alpha enables IEA UniProt
InterPro
TreeGrafter
GO_REF:0000002 GO_REF:0000003 GO_REF:0000118 NCBI chrNW_004624849:3,159,432...3,196,235
Ensembl chrNW_004624849:3,159,810...3,194,860
JBrowse link
G Top3b DNA topoisomerase III beta enables IEA InterPro
UniProt
TreeGrafter
GO_REF:0000002 GO_REF:0000003 GO_REF:0000118 NCBI chrNW_004624747:1,450,236...1,473,467
Ensembl chrNW_004624747:1,446,412...1,473,600
JBrowse link
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101702367 DNA topoisomerase 2-alpha enables IEA UniProt
InterPro
GO_REF:0000002 GO_REF:0000104 GO_REF:0000117 NCBI chrNW_004624795:2,903,686...2,927,028
Ensembl chrNW_004624795:2,898,038...2,926,049
JBrowse link
G Spo11 SPO11 initiator of meiotic double strand breaks enables IEA InterPro GO_REF:0000002 NCBI chrNW_004624741:23,784,362...23,800,127
Ensembl chrNW_004624741:23,784,298...23,800,168
JBrowse link
G Top2b DNA topoisomerase II beta enables IEA UniProt
InterPro
GO_REF:0000002 GO_REF:0000104 GO_REF:0000117 NCBI chrNW_004624788:3,493,188...3,590,138 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 16315
    catalytic activity 5042
      isomerase activity 158
        DNA topoisomerase activity 6
          DNA topoisomerase type I (single strand cut, ATP-independent) activity 3
          DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity + 3
          reverse gyrase activity 0
Path 2
Term Annotations click to browse term
  molecular_function 16315
    catalytic activity 5042
      catalytic activity, acting on a nucleic acid 567
        catalytic activity, acting on DNA 233
          DNA topoisomerase activity 6
            DNA topoisomerase type I (single strand cut, ATP-independent) activity 3
            DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity + 3
            reverse gyrase activity 0
paths to the root