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ONTOLOGY REPORT - ANNOTATIONS

Term:DNA-(apurinic or apyrimidinic site) endonuclease activity
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Accession:GO:0003906 term browser browse the term
Definition:Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).
Comment:Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV.
Synonyms:exact_synonym: AP deoxyendoribonuclease activity;   abasic deoxyendoribonuclease activity;   apurinic deoxyendoribonuclease activity;   apurinic/apyrimidinic endodeoxyribonuclease activity;   apyrimidinic deoxyendoribonuclease activity;   deoxyribonuclease (apurinic or apyrimidinic) activity
 broad_synonym: UV endonuclease
 related_synonym: endonuclease VIII activity
 xref: reactome:R-HSA-110375 "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break";   reactome:R-HSA-5649711 "NEIL1,NEIL2 incises DNA strand 5' to the AP site";   reactome:R-HSA-5649725 "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)"


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DNA-(apurinic or apyrimidinic site) endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISS
IEA
IBA
ISO		 GO_REF:0000024
GO_REF:0000118
GO_REF:0000033
(PMID:15707971), (PMID:18973764), (PMID:19188445), (PMID:24703901), (PMID:8932386)		 UniProt
TreeGrafter
GO_Central
RGD		 PMID:8932386 PMID:15707971 PMID:18973764 PMID:19188445 PMID:24703901 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Apex2 apurinic/apyrimidinic endodeoxyribonuclease 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:19,425,684...19,508,459
Ensembl chr  X:19,487,419...19,508,439 		JBrowse link
G Apex2l1 APEX nuclease (apurinic/apyrimidinic endonuclease) 2-like 1 enables IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr14:67,166,252...67,168,138
Ensembl chr14:67,166,530...67,168,080 		JBrowse link
G Aplf aprataxin and PNKP like factor enables ISO
IBA		 (PMID:17396150)
GO_REF:0000033		 RGD
GO_Central		 PMID:17396150 GO_REF:0000033 NCBI chr 4:120,070,471...120,122,656
Ensembl chr 4:120,070,471...120,122,633 		JBrowse link
G Hmces 5-hydroxymethylcytosine binding, ES cell specific NOT|enables ISS
ISO		 GO_REF:0000024
(PMID:30554877)		 UniProt
RGD		 PMID:30554877 GO_REF:0000024 NCBI chr 4:120,392,812...120,415,616
Ensembl chr 4:120,366,542...120,415,616 		JBrowse link
G Hmga1 high mobility group AT-hook 1 enables ISO (PMID:19465398) RGD PMID:19465398 NCBI chr20:5,611,088...5,618,755
Ensembl chr20:5,611,694...5,618,752 		JBrowse link
G Hmga2 high mobility group AT-hook 2 enables ISS
ISO		 GO_REF:0000024
(PMID:19465398)		 UniProt
RGD		 PMID:19465398 GO_REF:0000024 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784 		JBrowse link
G Neil1 nei-like DNA glycosylase 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:57,550,142...57,556,884
Ensembl chr 8:57,550,147...57,556,258 		JBrowse link
G Neil2 nei-like DNA glycosylase 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:37,444,676...37,454,863
Ensembl chr15:37,445,381...37,454,863 		JBrowse link
G Neil3 nei-like DNA glycosylase 3 enables ISO
IBA		 (PMID:19170771)
GO_REF:0000033
(MGI:4440390|PMID:20185759)		 RGD
GO_Central		 PMID:19170771 PMID:20185759 GO_REF:0000033 MGI:4440390 NCBI chr16:38,359,305...38,418,528
Ensembl chr16:38,359,371...38,418,527 		JBrowse link
G Nthl1 nth-like DNA glycosylase 1 enables ISO
IBA		 (PMID:8990169), (PMID:9927729)
GO_REF:0000033
(MGI:1289919|PMID:9743625)		 RGD
GO_Central		 PMID:8990169 PMID:9743625 PMID:9927729 GO_REF:0000033 MGI:1289919 NCBI chr10:13,655,791...13,661,958
Ensembl chr10:13,655,785...13,661,957 		JBrowse link
G Rps3 ribosomal protein S3 enables ISO (PMID:15707971), (PMID:16737853), (PMID:18610840), (PMID:19059439), (PMID:7775413)
(MGI:3529384|PMID:15707971)		 RGD PMID:7775413 PMID:15707971 PMID:16737853 PMID:18610840 PMID:19059439 MGI:3529384 NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680 		JBrowse link
class I DNA-(apurinic or apyrimidinic site) endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh1 alkB homolog 1, histone H2A dioxygenase enables ISO (PMID:19959401) RGD PMID:19959401 NCBI chr 6:107,068,301...107,088,784
Ensembl chr 6:107,068,475...107,088,759 		JBrowse link
G Neil2 nei-like DNA glycosylase 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:37,444,676...37,454,863
Ensembl chr15:37,445,381...37,454,863 		JBrowse link
G Neil3 nei-like DNA glycosylase 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr16:38,359,305...38,418,528
Ensembl chr16:38,359,371...38,418,527 		JBrowse link
G Nthl1 nth-like DNA glycosylase 1 enables ISO (PMID:8990169) RGD PMID:8990169 NCBI chr10:13,655,791...13,661,958
Ensembl chr10:13,655,785...13,661,957 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Polb DNA polymerase beta enables ISO (PMID:9614142) RGD PMID:9614142 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812 		JBrowse link
G Rps3 ribosomal protein S3 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680 		JBrowse link
G Rps3l1 ribosomal protein S3 like 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 3:51,559,683...51,560,522
Ensembl chr 3:51,559,683...51,560,524 		JBrowse link
class II DNA-(apurinic or apyrimidinic site) endonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISO
ISS
IEA		 (PMID:11160897), (PMID:11286553), (PMID:1627644), (PMID:9804798)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:1627644 PMID:9804798 PMID:11160897 PMID:11286553 GO_REF:0000024 GO_REF:0000107 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      catalytic activity, acting on a nucleic acid 642
        catalytic activity, acting on DNA 260
          DNA-(apurinic or apyrimidinic site) endonuclease activity 16
            class I DNA-(apurinic or apyrimidinic site) endonuclease activity 8
            class II DNA-(apurinic or apyrimidinic site) endonuclease activity 1
            class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity 0
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