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ONTOLOGY REPORT - ANNOTATIONS


Term:6-pyruvoyltetrahydropterin synthase activity
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Accession:GO:0003874 term browser browse the term
Definition:Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate.
Synonyms:related_synonym: 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity;   2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming);   6-pyruvoyl tetrahydrobiopterin synthase activity;   PTPS activity
 xref: EC:4.2.3.12;   KEGG_REACTION:R04286;   MetaCyc:4.2.3.12-RXN;   RHEA:22048;   reactome:R-HSA-1474184 "DHNTP is dephosphorylated by PTPS to PTHP"



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6-pyruvoyltetrahydropterin synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pts 6-pyruvoyl-tetrahydropterin synthase enables IDA
ISO
(MGI:1328867|PMID:9894812) RGD PMID:9894812 PMID:1939130 MGI:1328867, RGD:68294 NCBI chr 8:50,870,838...50,877,878
Ensembl chr 8:50,870,841...50,877,869
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  molecular_function 19983
    catalytic activity 5668
      lyase activity 207
        carbon-oxygen lyase activity 89
          carbon-oxygen lyase activity, acting on phosphates 5
            6-pyruvoyltetrahydropterin synthase activity 1
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