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ONTOLOGY REPORT - ANNOTATIONS


Term:gamma-glutamylcyclotransferase activity
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Accession:GO:0003839 term browser browse the term
Definition:Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.
Synonyms:exact_synonym: (5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing);   L-glutamic cyclase activity;   gamma-L-glutamylcyclotransferase activity;   gamma-glutamyl-amino acid cyclotransferase activity
 xref: EC:4.3.2.9;   MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN;   RHEA:20505;   reactome:R-HSA-1247922 "GGCT transforms gGluCys to OPRO";   reactome:R-HSA-6785928 "CHAC1,2 cleaves GSH to OPRO and CysGly"



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gamma-glutamylcyclotransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 enables IEA UniProt
TreeGrafter
GO_REF:0000104 GO_REF:0000118 NCBI chr 1:130,360,510...130,363,332
Ensembl chr 1:130,360,514...130,363,308
JBrowse link
G CHAC2 ChaC glutathione specific gamma-glutamylcyclotransferase 2 enables IEA UniProt
TreeGrafter
GO_REF:0000104 GO_REF:0000118 NCBI chr 3:87,405,937...87,417,268
Ensembl chr 3:87,405,978...87,416,260
JBrowse link
G GGCT gamma-glutamylcyclotransferase enables IEA UniProt
InterPro
Ensembl
TreeGrafter
GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr18:42,410,734...42,418,534
Ensembl chr18:42,410,792...42,418,980
JBrowse link

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  molecular_function 18689
    catalytic activity 5662
      lyase activity 202
        carbon-nitrogen lyase activity 14
          amidine-lyase activity 7
            gamma-glutamylcyclotransferase activity 3
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