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ONTOLOGY REPORT - ANNOTATIONS

Term:protein disulfide isomerase activity
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Accession:GO:0003756 term browser browse the term
Definition:Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.
Synonyms:exact_synonym: disulphide bond formation;   protein disulphide isomerase activity;   protein thiol-disulfide exchange;   protein thiol-disulphide exchange
 broad_synonym: protein disulfide-isomerase
 related_synonym: S-S rearrangase activity;   protein cysteine-thiol oxidation
 alt_id: GO:0006467
 xref: EC:5.3.4.1;   MetaCyc:5.3.4.1-RXN;   reactome:R-HSA-8950113 "IL12A binds IL12B";   reactome:R-HSA-8950183 "IL12B binds IL23A";   reactome:R-HSA-8950456 "IL12B dimerizes"


show annotations for term's descendants           Sort by:
protein disulfide isomerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creld1 cysteine-rich with EGF-like domains 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:146,631,883...146,641,493
Ensembl chr 4:146,631,883...146,641,499 		JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543 		JBrowse link
G Enox1 ecto-NOX disulfide-thiol exchanger 1 enables ISO
IBA		 (PMID:19055324)
GO_REF:0000033		 RGD
GO_Central		 PMID:19055324 GO_REF:0000033 NCBI chr15:52,517,833...53,079,752
Ensembl chr15:52,515,178...53,079,749 		JBrowse link
G Erp27 endoplasmic reticulum protein 27 NOT|enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:169,804,656...169,821,660
Ensembl chr 4:169,804,658...169,821,660 		JBrowse link
G Erp44 endoplasmic reticulum protein 44 enables ISO
IBA		 (PMID:11847130)
GO_REF:0000033		 RGD
GO_Central		 PMID:11847130 GO_REF:0000033 NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761 		JBrowse link
G Itgb3 integrin subunit beta 3 enables ISO
IEA		 (PMID:12204115), (PMID:15466936)
GO_REF:0000107		 RGD
Ensembl		 PMID:12204115 PMID:15466936 GO_REF:0000107 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta enables IMP
ISO
IBA
IEA		 (PMID:15225124), (PMID:15720785), (PMID:21091435), (PMID:32149426)
GO_REF:0000033
GO_REF:0000002		 RGD
GO_Central
InterPro		 PMID:15225124 PMID:15720785 PMID:21091435 PMID:32149426 PMID:2841089 GO_REF:0000002 GO_REF:0000033, RGD:633506 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500 		JBrowse link
G Pdia2 protein disulfide isomerase family A, member 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 enables IEA
IBA		 GO_REF:0000003
GO_REF:0000033
GO_REF:0000002		 UniProt
GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 enables IDA
ISO
IBA
IEA		 (PMID:28576878)
GO_REF:0000033
GO_REF:0000002
GO_REF:0000003
PMID:22665516		 RGD
GO_Central
InterPro
UniProt		 PMID:28576878 PMID:8477750 PMID:22665516 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033, RGD:632673, RGD:8553430 NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107 		JBrowse link
G Pdia5 protein disulfide isomerase family A, member 5 enables ISO
IBA		 (PMID:14627699)
GO_REF:0000033		 RGD
GO_Central		 PMID:14627699 GO_REF:0000033 NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 enables ISS
IEA		 GO_REF:0000024
GO_REF:0000002
GO_REF:0000003		 UniProt
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613 		JBrowse link
G Pdia6l1 protein disulfide isomerase family A, member 6 like 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:47,606,582...47,607,800
Ensembl chr 4:47,606,582...47,607,800 		JBrowse link
G Pdilt protein disulfide isomerase-like, testis expressed enables ISO MGI:5316367 (PMID:22357757) RGD PMID:22357757 NCBI chr 1:173,837,477...173,868,685
Ensembl chr 1:173,837,478...173,868,685 		JBrowse link
G Qsox1 quiescin sulfhydryl oxidase 1 enables ISO
IBA
ISS		 (PMID:17331072), (PMID:18393449)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:17331072 PMID:18393449 GO_REF:0000024 GO_REF:0000033 NCBI chr13:67,949,780...67,987,434
Ensembl chr13:67,949,780...67,987,459 		JBrowse link
G Qsox2 quiescin sulfhydryl oxidase 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:9,034,994...9,064,649
Ensembl chr 3:9,034,994...9,064,664 		JBrowse link
G Tmx1 thioredoxin-related transmembrane protein 1 enables ISO (PMID:29932915) RGD PMID:29932915 NCBI chr 6:88,960,691...88,971,744
Ensembl chr 6:88,960,695...88,971,301 		JBrowse link
G Txndc2 thioredoxin domain containing 2 enables ISO (PMID:12149401) RGD PMID:12149401 NCBI chr 9:105,230,575...105,235,131
Ensembl chr 9:105,230,578...105,235,126 		JBrowse link
G Txndc5 thioredoxin domain containing 5 enables IBA
ISO		 GO_REF:0000033
UniProtKB:P17967 (PMID:12930873)		 GO_Central
RGD		 PMID:12930873 GO_REF:0000033 NCBI chr17:26,289,880...26,318,025
Ensembl chr17:26,289,880...26,318,025 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      catalytic activity, acting on a protein 2509
        protein disulfide isomerase activity 19
Path 2
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      isomerase activity 212
        intramolecular oxidoreductase activity 68
          intramolecular oxidoreductase activity, transposing S-S bonds 19
            protein disulfide isomerase activity 19
paths to the root