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ONTOLOGY REPORT - ANNOTATIONS

Term:peptidyl-prolyl cis-trans isomerase activity
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Accession:GO:0003755 term browser browse the term
Definition:Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
Synonyms:exact_synonym: cis-trans proline isomerase activity
 narrow_synonym: FK506-sensitive peptidyl-prolyl cis-trans isomerase;   cyclophilin-type peptidyl-prolyl cis-trans isomerase activity;   juglone-sensitive cis-trans proline isomerase activity;   juglone-sensitive peptidyl-prolyl cis-trans isomerase activity
 related_synonym: PPIase activity;   cyclophilin activity;   immunophilin;   parvulin;   peptide bond isomerase activity;   peptidyl-prolyl isomerase B reaction;   peptidylproline cis-trans-isomerase activity;   peptidylprolyl cis-trans isomerase activity;   peptidylprolyl isomerase activity;   rotamase activity
 alt_id: GO:0004752;   GO:0042028
 xref: EC:5.2.1.8;   MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN;   RHEA:16237;   reactome:R-HSA-2022073 "Procollagen triple helix formation";   reactome:R-HSA-9626816 "PIN1 binds p-S345-NCF1"


show annotations for term's descendants           Sort by:
peptidyl-prolyl cis-trans isomerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:201,408,002...201,419,220
Ensembl chr 1:201,407,288...201,419,122 		JBrowse link
G Aipl1 aryl hydrocarbon receptor-interacting protein-like 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:56,655,693...56,664,922
Ensembl chr10:56,655,693...56,664,922 		JBrowse link
G Cwc27 CWC27 spliceosome associated cyclophilin NOT|enables ISO
IEA		 (PMID:20676357)
GO_REF:0000002		 RGD
InterPro		 PMID:20676357 GO_REF:0000002 NCBI chr 2:35,764,674...35,975,908
Ensembl chr 2:35,764,686...35,975,872 		JBrowse link
G ENSRNOG00000062802 enables IEA GO_REF:0000104 UniProt GO_REF:0000104 Ensembl chr 6:50,647,961...50,648,980 JBrowse link
G ENSRNOG00000063066 enables IEA GO_REF:0000104 UniProt GO_REF:0000104 Ensembl chr 8:65,669,645...65,670,408 JBrowse link
G ENSRNOG00000065084 enables IEA GO_REF:0000104 UniProt GO_REF:0000104 Ensembl chr14:20,090,914...20,091,715 JBrowse link
G ENSRNOG00000066761 enables IEA GO_REF:0000104 UniProt GO_REF:0000104 Ensembl chr 1:225,740,283...225,742,143 JBrowse link
G ENSRNOG00000067128 enables IEA GO_REF:0000104 UniProt GO_REF:0000104 Ensembl chr 9:76,313,221...76,313,685 JBrowse link
G ENSRNOG00000067890 enables IEA GO_REF:0000104 UniProt GO_REF:0000104 Ensembl chr 5:146,987,628...146,988,217 JBrowse link
G ENSRNOG00000068459 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 Ensembl chr14:6,679,295...6,680,432 JBrowse link
G ENSRNOG00000068575 enables IEA GO_REF:0000104 UniProt GO_REF:0000104 Ensembl chr10:79,800,920...79,802,510 JBrowse link
G ENSRNOG00000070232 enables IEA GO_REF:0000104 UniProt GO_REF:0000104 Ensembl chr14:8,916,368...8,917,014 JBrowse link
G ENSRNOG00000071104 enables IEA GO_REF:0000104 UniProt GO_REF:0000104 Ensembl chr 4:87,855,579...87,857,086 JBrowse link
G Fkbp10 FKBP prolyl isomerase 10 enables IBA
ISO		 GO_REF:0000033
(PMID:7493967)		 GO_Central
RGD		 PMID:7493967 GO_REF:0000033 NCBI chr10:85,345,434...85,357,998
Ensembl chr10:85,346,126...85,427,330 		JBrowse link
G Fkbp11 FKBP prolyl isomerase 11 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:129,871,870...129,877,760
Ensembl chr 7:129,871,870...129,875,303 		JBrowse link
G Fkbp14 FKBP prolyl isomerase 14 enables IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:83,705,531...83,721,515
Ensembl chr 4:83,705,652...83,721,528 		JBrowse link
G Fkbp15 FKBP prolyl isomerase family member 15 NOT|enables ISO (PMID:16756961) RGD PMID:16756961 NCBI chr 5:75,750,786...75,815,038
Ensembl chr 5:75,750,787...75,814,990 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A enables ISO
IEA
IBA		 (PMID:1696686), (PMID:1701173), (PMID:2477715)
GO_REF:0000043
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:1696686 PMID:1701173 PMID:2477715 GO_REF:0000033 GO_REF:0000043 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743 		JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B enables ISO
IEA
IBA		 (PMID:7592869)
(PMID:7513996)
GO_REF:0000043
GO_REF:0000033
(PMID:16481613)		 RGD
UniProt
GO_Central		 PMID:7513996 PMID:7592869 PMID:16481613 GO_REF:0000033 GO_REF:0000043 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653 		JBrowse link
G Fkbp2 FKBP prolyl isomerase 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:204,167,724...204,170,399
Ensembl chr 1:204,167,726...204,170,420 		JBrowse link
G Fkbp3 FKBP prolyl isomerase 3 enables IEA GO_REF:0000003
GO_REF:0000043		 UniProt GO_REF:0000003 GO_REF:0000043 NCBI chr 6:83,113,885...83,125,500
Ensembl chr 6:83,113,786...83,127,011 		JBrowse link
G Fkbp4 FKBP prolyl isomerase 4 enables ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:11350175)
GO_REF:0000043
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:11350175 GO_REF:0000024 GO_REF:0000033 GO_REF:0000043 NCBI chr 4:161,703,379...161,711,833
Ensembl chr 4:161,703,379...161,711,833 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 enables ISO
IBA		 (PMID:11350175)
GO_REF:0000033		 RGD
GO_Central		 PMID:11350175 GO_REF:0000033 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Fkbp6 FKBP prolyl isomerase family member 6 NOT|enables ISS
ISO
IEA		 GO_REF:0000024
(MGI:5439219|PMID:22902560)
GO_REF:0000043		 UniProt
RGD		 PMID:22902560 GO_REF:0000024 GO_REF:0000043 MGI:5439219 NCBI chr12:21,318,251...21,390,350
Ensembl chr12:21,319,568...21,390,350 		JBrowse link
G Fkbp7 FKBP prolyl isomerase 7 enables IEA GO_REF:0000003
GO_REF:0000043
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000043 GO_REF:0000116 NCBI chr 3:61,609,384...61,623,710
Ensembl chr 3:61,608,557...61,623,280 		JBrowse link
G Fkbp8 FKBP prolyl isomerase 8 enables IEA GO_REF:0000116
GO_REF:0000003
GO_REF:0000043		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000043 GO_REF:0000116 NCBI chr16:18,895,608...18,902,648
Ensembl chr16:18,893,576...18,902,612 		JBrowse link
G Fkbp9 FKBP prolyl isomerase 9 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:86,106,256...86,156,723
Ensembl chr 4:86,106,282...86,156,721 		JBrowse link
G LOC100909955 peptidyl-prolyl cis-trans isomerase A-like enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:23,743,575...23,753,559 JBrowse link
G LOC100911252 peptidyl-prolyl cis-trans isomerase A-like enables IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 4:41,828,873...41,829,619
Ensembl chr 4:41,828,867...41,829,622 		JBrowse link
G LOC134479414 RING-type E3 ubiquitin-protein ligase PPIL2-like enables IEA GO_REF:0000002 InterPro GO_REF:0000002
G Nktr natural killer cell triggering receptor enables ISO
IBA		 (PMID:20676357)
GO_REF:0000033		 RGD
GO_Central		 PMID:20676357 GO_REF:0000033 NCBI chr 8:121,380,010...121,420,495
Ensembl chr 8:121,382,436...121,418,314 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 enables ISO
IBA		 (PMID:19122240), (PMID:20956805), (PMID:29686383)
GO_REF:0000033
(MGI:3620333|PMID:16554819), (MGI:6158095|PMID:29686383), (PMID:17548053)		 RGD
GO_Central		 PMID:16554819 PMID:17548053 PMID:19122240 PMID:20956805 PMID:29686383 GO_REF:0000033 MGI:3620333 MGI:6158095 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785 		JBrowse link
G Pin4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 enables IEA GO_REF:0000003
GO_REF:0000104		 UniProt GO_REF:0000003 GO_REF:0000104 NCBI chr  X:67,232,066...67,238,709
Ensembl chr  X:67,232,081...67,238,702 		JBrowse link
G Ppia peptidylprolyl isomerase A enables IEA
ISO
ISS
IBA		 GO_REF:0000003
(PMID:14993672), (PMID:2001362), (PMID:20676357), (PMID:21245143), (PMID:21593166), (PMID:25678563)
GO_REF:0000116
(MGI:6450355|PMID:24429998)
GO_REF:0000024
GO_REF:0000104
GO_REF:0000033		 UniProt
RGD
RHEA
GO_Central		 PMID:2001362 PMID:14993672 PMID:20676357 PMID:21245143 PMID:21593166 More... GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 GO_REF:0000116 MGI:6450355 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601 		JBrowse link
G Ppia-ps13 peptidylprolyl isomerase A, pseudogene 13 enables IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr16:29,386,385...29,387,079
Ensembl chr16:29,386,612...29,387,070
Ensembl chr16:29,386,612...29,387,070 		JBrowse link
G Ppial4d peptidylprolyl isomerase A (cyclophilin A)-like 4D enables ISS
IBA		 GO_REF:0000024
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 NCBI chr14:21,006,522...21,007,284
Ensembl chr14:21,006,538...21,007,310 		JBrowse link
G Ppial4g peptidylprolyl isomerase A like 4G enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:74,015,628...74,016,215
Ensembl chr15:74,015,628...74,016,215 		JBrowse link
G Ppib peptidylprolyl isomerase B enables ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:20676357)
GO_REF:0000104
GO_REF:0000033		 UniProt
CAFA
RGD
GO_Central		 PMID:20676357 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr 8:66,603,877...66,609,734
Ensembl chr 8:66,603,861...66,630,428 		JBrowse link
G Ppic peptidylprolyl isomerase C enables ISO
IBA		 (PMID:20676357)
(MGI:65336|PMID:1652374)
GO_REF:0000033		 RGD
GO_Central		 PMID:1652374 PMID:20676357 GO_REF:0000033 MGI:65336 NCBI chr18:46,842,410...46,855,016
Ensembl chr18:46,842,409...46,855,017 		JBrowse link
G Ppid peptidylprolyl isomerase D enables IDA
ISO
IEA
IBA		 (PMID:11350175), (PMID:20676357)
GO_REF:0000043
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:11350175 PMID:20676357 PMID:12077116 GO_REF:0000033 GO_REF:0000043, RGD:625503 NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221 		JBrowse link
G Ppidl1 peptidylprolyl isomerase D-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:112,843,668...112,844,916
Ensembl chr 9:112,843,665...112,844,992 		JBrowse link
G Ppie peptidylprolyl isomerase E enables ISO
IBA		 (PMID:18258190), (PMID:20676357)
GO_REF:0000033		 RGD
GO_Central		 PMID:18258190 PMID:20676357 GO_REF:0000033 NCBI chr 5:135,406,172...135,419,332
Ensembl chr 5:135,406,176...135,419,235 		JBrowse link
G Ppif peptidylprolyl isomerase F enables IDA
ISO
IEA
IBA		 (PMID:20676357)
GO_REF:0000104
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:20676357 PMID:1599421 PMID:15233627 GO_REF:0000033 GO_REF:0000104, RGD:729430, RGD:2303985 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913 		JBrowse link
G Ppig peptidylprolyl isomerase G enables IDA
ISO
IEA
IBA		 (PMID:20676357)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:20676357 PMID:9525923 GO_REF:0000033 GO_REF:0000107, RGD:633708 NCBI chr 3:54,484,023...54,512,929
Ensembl chr 3:54,484,023...54,512,926 		JBrowse link
G Ppih peptidylprolyl isomerase H enables ISO
IBA		 (PMID:20676357), (PMID:9570313)
GO_REF:0000033		 RGD
GO_Central		 PMID:9570313 PMID:20676357 GO_REF:0000033 NCBI chr 5:132,906,324...132,924,341
Ensembl chr 5:132,906,328...132,924,267 		JBrowse link
G Ppil1 peptidylprolyl isomerase like 1 enables ISO
IBA		 (PMID:16595688), (PMID:20676357)
GO_REF:0000033		 RGD
GO_Central		 PMID:16595688 PMID:20676357 GO_REF:0000033 NCBI chr20:7,302,292...7,322,349
Ensembl chr20:7,302,621...7,322,354 		JBrowse link
G Ppil2 peptidylprolyl isomerase like 2 NOT|enables ISO (PMID:20676357) RGD PMID:20676357 NCBI chr11:83,897,719...83,920,970
Ensembl chr11:83,897,764...83,922,144 		JBrowse link
G Ppil2-ps1 peptidylprolyl isomerase like 2, pseudogene 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:100,024,128...100,025,851
Ensembl chr 6:100,024,246...100,025,811 		JBrowse link
G Ppil3 peptidylprolyl isomerase like 3 enables IEA
IBA		 GO_REF:0000104
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000104 NCBI chr 9:59,966,405...59,980,147
Ensembl chr 9:59,964,919...59,979,886 		JBrowse link
G Ppil4 peptidylprolyl isomerase like 4 enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:2,273,582...2,305,639
Ensembl chr 1:2,273,609...2,305,632 		JBrowse link
G Ppil6 peptidylprolyl isomerase like 6 NOT|enables ISO (PMID:20676357) RGD PMID:20676357 NCBI chr20:44,989,509...45,017,833
Ensembl chr20:44,988,943...45,018,340 		JBrowse link
G Ppwd1 peptidylprolyl isomerase domain and WD repeat containing 1 enables ISO
IBA		 (PMID:20676357)
GO_REF:0000033		 RGD
GO_Central		 PMID:20676357 GO_REF:0000033 NCBI chr 2:35,337,301...35,360,661
Ensembl chr 2:35,335,962...35,360,460 		JBrowse link
G Ptpa protein phosphatase 2 phosphatase activator enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:13,689,742...13,720,287
Ensembl chr 3:13,689,741...13,722,549 		JBrowse link
G Ranbp2 RAN binding protein 2 NOT|enables ISO (PMID:20676357) RGD PMID:20676357 NCBI chr20:26,442,156...26,493,481
Ensembl chr20:26,442,217...26,493,481 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      catalytic activity, acting on a protein 2516
        peptidyl-prolyl cis-trans isomerase activity 54
          RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity + 0
Path 2
Term Annotations click to browse term
  molecular_function 21010
    catalytic activity 6145
      isomerase activity 210
        cis-trans isomerase activity 57
          peptidyl-prolyl cis-trans isomerase activity 54
            RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity + 0
paths to the root