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ONTOLOGY REPORT - ANNOTATIONS

Term:peptidyl-prolyl cis-trans isomerase activity
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Accession:GO:0003755 term browser browse the term
Definition:Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
Synonyms:exact_synonym: cis-trans proline isomerase activity
 narrow_synonym: FK506-sensitive peptidyl-prolyl cis-trans isomerase;   cyclophilin-type peptidyl-prolyl cis-trans isomerase activity;   juglone-sensitive cis-trans proline isomerase activity;   juglone-sensitive peptidyl-prolyl cis-trans isomerase activity
 related_synonym: PPIase activity;   cyclophilin activity;   immunophilin;   parvulin;   peptide bond isomerase activity;   peptidyl-prolyl isomerase B reaction;   peptidylproline cis-trans-isomerase activity;   peptidylprolyl cis-trans isomerase activity;   peptidylprolyl isomerase activity;   rotamase activity
 alt_id: GO:0004752;   GO:0042028
 xref: EC:5.2.1.8;   MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN;   RHEA:16237;   reactome:R-HSA-2022073 "Procollagen triple helix formation";   reactome:R-HSA-9626816 "PIN1 binds p-S345-NCF1"


show annotations for term's descendants           Sort by:
peptidyl-prolyl cis-trans isomerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein enables IEA InterPro GO_REF:0000002 NCBI chr19:4,163,756...4,177,233
Ensembl chr19:4,164,446...4,175,858 		JBrowse link
G Aipl1 aryl hydrocarbon receptor-interacting protein-like 1 enables IEA InterPro GO_REF:0000002 NCBI chr11:71,919,527...71,933,184
Ensembl chr11:71,918,789...71,928,335 		JBrowse link
G Cwc27 CWC27 spliceosome-associated protein NOT|enables ISO
IEA		 (PMID:20676357) UniProt
InterPro		 PMID:20676357 GO_REF:0000002 NCBI chr13:104,767,648...104,953,649
Ensembl chr13:104,767,648...104,953,650 		JBrowse link
G Fkbp10 FK506 binding protein 10 enables IDA
IBA		 (PMID:7493967) MGI
GO_Central		 PMID:7493967 GO_REF:0000033 NCBI chr11:100,306,520...100,315,666
Ensembl chr11:100,306,523...100,315,650 		JBrowse link
G Fkbp11 FK506 binding protein 11 enables IBA GO_Central GO_REF:0000033 NCBI chr15:98,622,249...98,626,079
Ensembl chr15:98,622,247...98,626,079 		JBrowse link
G Fkbp15 FK506 binding protein 15 NOT|enables IDA (PMID:16756961) MGI PMID:16756961 NCBI chr 4:62,218,579...62,278,828
Ensembl chr 4:62,218,579...62,278,785 		JBrowse link
G Fkbp1a FK506 binding protein 1a enables ISO
IBA		 GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr 2:151,384,403...151,403,611
Ensembl chr 2:151,384,403...151,403,612 		JBrowse link
G Fkbp1b FK506 binding protein 1b enables IDA
IBA
ISO		 (PMID:16481613) MGI
GO_Central		 PMID:16481613 GO_REF:0000033 GO_REF:0000119 NCBI chr12:4,883,174...4,891,736
Ensembl chr12:4,883,174...4,891,591 		JBrowse link
G Fkbp2 FK506 binding protein 2 enables IBA GO_Central GO_REF:0000033 NCBI chr19:6,955,105...6,957,832
Ensembl chr19:6,955,109...6,957,869 		JBrowse link
G Fkbp4 FK506 binding protein 4 enables ISO
IBA
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr 6:128,407,066...128,415,619
Ensembl chr 6:128,406,698...128,415,640 		JBrowse link
G Fkbp5 FK506 binding protein 5 enables ISO
IBA
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr17:28,617,727...28,705,123
Ensembl chr17:28,618,068...28,736,501 		JBrowse link
G Fkbp6 FK506 binding protein 6 NOT|enables IDA (PMID:22902560) UniProt PMID:22902560 NCBI chr 5:135,320,558...135,380,662
Ensembl chr 5:135,320,558...135,378,898 		JBrowse link
G Fkbp9 FK506 binding protein 9 enables IBA GO_Central GO_REF:0000033 NCBI chr 6:56,809,044...56,856,345
Ensembl chr 6:56,809,044...56,856,343 		JBrowse link
G Nktr natural killer tumor recognition sequence enables ISO
IBA
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr 9:121,542,244...121,585,908
Ensembl chr 9:121,548,235...121,585,909 		JBrowse link
G Pin1 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 enables IDA
IBA
ISO		 (PMID:16554819), (PMID:17548053), (PMID:29686383) UniProt
GO_Central		 PMID:16554819 PMID:17548053 PMID:29686383 GO_REF:0000033 GO_REF:0000119 NCBI chr 9:20,563,335...20,575,008
Ensembl chr 9:20,563,391...20,577,880 		JBrowse link
G Pin1rt1 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1, retrogene 1 enables IDA
IBA
ISO		 (PMID:17548053) MGI
GO_Central		 PMID:17548053 GO_REF:0000033 GO_REF:0000119 NCBI chr 2:104,544,232...104,546,707
Ensembl chr 2:104,544,271...104,546,724 		JBrowse link
G Ppia peptidylprolyl isomerase A enables ISS
IBA
IMP
ISO		 (PMID:24429998) UniProt
GO_Central		 PMID:24429998 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr11:6,365,867...6,369,817
Ensembl chr11:6,365,443...6,369,817 		JBrowse link
G Ppib peptidylprolyl isomerase B enables ISS
IBA
ISO		 CAFA
GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr 9:65,967,451...65,973,911
Ensembl chr 9:65,967,504...65,973,905 		JBrowse link
G Ppic peptidylprolyl isomerase C enables ISO
IBA
IDA		 (PMID:1652374) GO_Central
UniProt		 PMID:1652374 GO_REF:0000033 GO_REF:0000119 NCBI chr18:53,539,413...53,551,079
Ensembl chr18:53,539,404...53,551,187 		JBrowse link
G Ppid peptidylprolyl isomerase D (cyclophilin D) enables ISO
IBA
ISS		 (PMID:8812478) RGD
GO_Central
UniProt
MGI		 PMID:8812478 PMID:12077116 GO_REF:0000024 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:625503 NCBI chr 3:79,498,644...79,511,117
Ensembl chr 3:79,498,649...79,510,957 		JBrowse link
G Ppie peptidylprolyl isomerase E (cyclophilin E) enables ISS
IBA
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr 4:123,020,907...123,033,783
Ensembl chr 4:123,020,908...123,033,744 		JBrowse link
G Ppif peptidylprolyl isomerase F (cyclophilin F) enables ISO
IBA
TAS
ISS		 (PMID:18309324) RGD
GO_Central
UniProt		 PMID:1599421 PMID:15233627 PMID:18309324 GO_REF:0000024 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:2303985 RGD:729430 NCBI chr14:25,693,998...25,700,892
Ensembl chr14:25,694,578...25,700,892 		JBrowse link
G Ppig peptidyl-prolyl isomerase G (cyclophilin G) enables ISO
IBA
ISS		 RGD
GO_Central
UniProt		 PMID:9525923 GO_REF:0000024 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:633708 NCBI chr 2:69,553,152...69,584,356
Ensembl chr 2:69,552,889...69,584,356 		JBrowse link
G Ppih peptidyl prolyl isomerase H enables ISS
IBA
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr 4:119,157,207...119,177,720
Ensembl chr 4:119,157,207...119,177,743 		JBrowse link
G Ppihl peptidyl prolyl isomerase H like enables ISO GO_Central GO_REF:0000119 NCBI chr 5:44,070,486...44,071,246
Ensembl chr 5:44,070,486...44,071,259 		JBrowse link
G Ppil1 peptidylprolyl isomerase (cyclophilin)-like 1 enables ISO
IBA
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr17:29,469,809...29,482,945
Ensembl chr17:29,469,777...29,483,160 		JBrowse link
G Ppil2 peptidylprolyl isomerase (cyclophilin)-like 2 NOT|enables ISO
IEA		 (PMID:20676357) UniProt
InterPro		 PMID:20676357 GO_REF:0000002 NCBI chr16:16,904,419...16,929,126
Ensembl chr16:16,904,419...16,929,121 		JBrowse link
G Ppil3 peptidylprolyl isomerase (cyclophilin)-like 3 enables IBA GO_Central GO_REF:0000033 NCBI chr 1:58,470,152...58,484,878
Ensembl chr 1:58,470,153...58,484,645 		JBrowse link
G Ppil6 peptidylprolyl isomerase (cyclophilin)-like 6 NOT|enables ISO
IEA		 (PMID:20676357) UniProt
InterPro		 PMID:20676357 GO_REF:0000002 NCBI chr10:41,366,414...41,390,286
Ensembl chr10:41,366,435...41,390,282 		JBrowse link
G Ppwd1 peptidylprolyl isomerase domain and WD repeat containing 1 enables ISS
IBA
ISO		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000119 NCBI chr13:104,340,102...104,365,378
Ensembl chr13:104,341,632...104,365,351 		JBrowse link
G Ptpa protein phosphatase 2 protein activator enables IBA GO_Central GO_REF:0000033 NCBI chr 2:30,306,062...30,337,819
Ensembl chr 2:30,306,051...30,337,818 		JBrowse link
G Ranbp2 RAN binding protein 2 NOT|enables ISO
IEA		 (PMID:20676357) UniProt
InterPro		 PMID:20676357 GO_REF:0000002 NCBI chr10:58,282,674...58,329,977
Ensembl chr10:58,282,742...58,330,178 		JBrowse link
RNA polymerase II CTD heptapeptide repeat P3 isomerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fkbp10 FK506 binding protein 10 enables IEA UniProt GO_REF:0000003 NCBI chr11:100,306,520...100,315,666
Ensembl chr11:100,306,523...100,315,650 		JBrowse link
G Fkbp11 FK506 binding protein 11 enables IEA UniProt GO_REF:0000003 NCBI chr15:98,622,249...98,626,079
Ensembl chr15:98,622,247...98,626,079 		JBrowse link
G Fkbp14 FK506 binding protein 14 enables IEA UniProt GO_REF:0000003 NCBI chr 6:54,554,590...54,574,329
Ensembl chr 6:54,554,589...54,574,293 		JBrowse link
G Fkbp1a FK506 binding protein 1a enables IEA UniProt GO_REF:0000003 NCBI chr 2:151,384,403...151,403,611
Ensembl chr 2:151,384,403...151,403,612 		JBrowse link
G Fkbp1b FK506 binding protein 1b enables IEA UniProt GO_REF:0000003 NCBI chr12:4,883,174...4,891,736
Ensembl chr12:4,883,174...4,891,591 		JBrowse link
G Fkbp2 FK506 binding protein 2 enables IEA UniProt GO_REF:0000003 NCBI chr19:6,955,105...6,957,832
Ensembl chr19:6,955,109...6,957,869 		JBrowse link
G Fkbp3 FK506 binding protein 3 enables IEA UniProt GO_REF:0000003 NCBI chr12:65,109,206...65,120,712
Ensembl chr12:65,109,198...65,120,781 		JBrowse link
G Fkbp4 FK506 binding protein 4 enables IEA UniProt GO_REF:0000003 NCBI chr 6:128,407,066...128,415,619
Ensembl chr 6:128,406,698...128,415,640 		JBrowse link
G Fkbp5 FK506 binding protein 5 enables IEA UniProt GO_REF:0000003 NCBI chr17:28,617,727...28,705,123
Ensembl chr17:28,618,068...28,736,501 		JBrowse link
G Fkbp7 FK506 binding protein 7 enables IEA UniProt GO_REF:0000003 NCBI chr 2:76,493,378...76,503,442
Ensembl chr 2:76,493,388...76,503,460 		JBrowse link
G Fkbp8 FK506 binding protein 8 enables IEA UniProt GO_REF:0000003 NCBI chr 8:70,980,371...70,987,978
Ensembl chr 8:70,980,374...70,987,978 		JBrowse link
G Fkbp9 FK506 binding protein 9 enables IEA UniProt GO_REF:0000003 NCBI chr 6:56,809,044...56,856,345
Ensembl chr 6:56,809,044...56,856,343 		JBrowse link
G Nktr natural killer tumor recognition sequence enables IEA UniProt GO_REF:0000003 NCBI chr 9:121,542,244...121,585,908
Ensembl chr 9:121,548,235...121,585,909 		JBrowse link
G Pin1 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 enables IEA UniProt GO_REF:0000003 NCBI chr 9:20,563,335...20,575,008
Ensembl chr 9:20,563,391...20,577,880 		JBrowse link
G Pin4 peptidyl-prolyl cis/trans isomerase, NIMA-interacting, 4 (parvulin) enables IEA UniProt GO_REF:0000003 NCBI chr  X:101,163,075...101,171,276
Ensembl chr  X:101,163,053...101,171,275 		JBrowse link
G Ppia peptidylprolyl isomerase A enables IEA UniProt GO_REF:0000003 NCBI chr11:6,365,867...6,369,817
Ensembl chr11:6,365,443...6,369,817 		JBrowse link
G Ppib peptidylprolyl isomerase B enables IEA UniProt GO_REF:0000003 NCBI chr 9:65,967,451...65,973,911
Ensembl chr 9:65,967,504...65,973,905 		JBrowse link
G Ppic peptidylprolyl isomerase C enables IEA UniProt GO_REF:0000003 NCBI chr18:53,539,413...53,551,079
Ensembl chr18:53,539,404...53,551,187 		JBrowse link
G Ppid peptidylprolyl isomerase D (cyclophilin D) enables IEA UniProt GO_REF:0000003 NCBI chr 3:79,498,644...79,511,117
Ensembl chr 3:79,498,649...79,510,957 		JBrowse link
G Ppie peptidylprolyl isomerase E (cyclophilin E) enables IEA UniProt GO_REF:0000003 NCBI chr 4:123,020,907...123,033,783
Ensembl chr 4:123,020,908...123,033,744 		JBrowse link
G Ppif peptidylprolyl isomerase F (cyclophilin F) enables IEA UniProt GO_REF:0000003 NCBI chr14:25,693,998...25,700,892
Ensembl chr14:25,694,578...25,700,892 		JBrowse link
G Ppig peptidyl-prolyl isomerase G (cyclophilin G) enables IEA UniProt GO_REF:0000003 NCBI chr 2:69,553,152...69,584,356
Ensembl chr 2:69,552,889...69,584,356 		JBrowse link
G Ppih peptidyl prolyl isomerase H enables IEA UniProt GO_REF:0000003 NCBI chr 4:119,157,207...119,177,720
Ensembl chr 4:119,157,207...119,177,743 		JBrowse link
G Ppil1 peptidylprolyl isomerase (cyclophilin)-like 1 enables IEA UniProt GO_REF:0000003 NCBI chr17:29,469,809...29,482,945
Ensembl chr17:29,469,777...29,483,160 		JBrowse link
G Ppil3 peptidylprolyl isomerase (cyclophilin)-like 3 enables IEA UniProt GO_REF:0000003 NCBI chr 1:58,470,152...58,484,878
Ensembl chr 1:58,470,153...58,484,645 		JBrowse link
G Ppil4 peptidylprolyl isomerase (cyclophilin)-like 4 enables IEA UniProt GO_REF:0000003 NCBI chr10:7,668,653...7,698,329
Ensembl chr10:7,668,655...7,698,899 		JBrowse link
G Ppwd1 peptidylprolyl isomerase domain and WD repeat containing 1 enables IEA UniProt GO_REF:0000003 NCBI chr13:104,340,102...104,365,378
Ensembl chr13:104,341,632...104,365,351 		JBrowse link
G Ptpa protein phosphatase 2 protein activator enables IEA UniProt GO_REF:0000003 NCBI chr 2:30,306,062...30,337,819
Ensembl chr 2:30,306,051...30,337,818 		JBrowse link
RNA polymerase II CTD heptapeptide repeat P6 isomerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fkbp10 FK506 binding protein 10 enables IEA UniProt GO_REF:0000003 NCBI chr11:100,306,520...100,315,666
Ensembl chr11:100,306,523...100,315,650 		JBrowse link
G Fkbp11 FK506 binding protein 11 enables IEA UniProt GO_REF:0000003 NCBI chr15:98,622,249...98,626,079
Ensembl chr15:98,622,247...98,626,079 		JBrowse link
G Fkbp14 FK506 binding protein 14 enables IEA UniProt GO_REF:0000003 NCBI chr 6:54,554,590...54,574,329
Ensembl chr 6:54,554,589...54,574,293 		JBrowse link
G Fkbp1a FK506 binding protein 1a enables IEA UniProt GO_REF:0000003 NCBI chr 2:151,384,403...151,403,611
Ensembl chr 2:151,384,403...151,403,612 		JBrowse link
G Fkbp1b FK506 binding protein 1b enables IEA UniProt GO_REF:0000003 NCBI chr12:4,883,174...4,891,736
Ensembl chr12:4,883,174...4,891,591 		JBrowse link
G Fkbp2 FK506 binding protein 2 enables IEA UniProt GO_REF:0000003 NCBI chr19:6,955,105...6,957,832
Ensembl chr19:6,955,109...6,957,869 		JBrowse link
G Fkbp3 FK506 binding protein 3 enables IEA UniProt GO_REF:0000003 NCBI chr12:65,109,206...65,120,712
Ensembl chr12:65,109,198...65,120,781 		JBrowse link
G Fkbp4 FK506 binding protein 4 enables IEA UniProt GO_REF:0000003 NCBI chr 6:128,407,066...128,415,619
Ensembl chr 6:128,406,698...128,415,640 		JBrowse link
G Fkbp5 FK506 binding protein 5 enables IEA UniProt GO_REF:0000003 NCBI chr17:28,617,727...28,705,123
Ensembl chr17:28,618,068...28,736,501 		JBrowse link
G Fkbp7 FK506 binding protein 7 enables IEA UniProt GO_REF:0000003 NCBI chr 2:76,493,378...76,503,442
Ensembl chr 2:76,493,388...76,503,460 		JBrowse link
G Fkbp8 FK506 binding protein 8 enables IEA UniProt GO_REF:0000003 NCBI chr 8:70,980,371...70,987,978
Ensembl chr 8:70,980,374...70,987,978 		JBrowse link
G Fkbp9 FK506 binding protein 9 enables IEA UniProt GO_REF:0000003 NCBI chr 6:56,809,044...56,856,345
Ensembl chr 6:56,809,044...56,856,343 		JBrowse link
G Nktr natural killer tumor recognition sequence enables IEA UniProt GO_REF:0000003 NCBI chr 9:121,542,244...121,585,908
Ensembl chr 9:121,548,235...121,585,909 		JBrowse link
G Pin1 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 enables IEA UniProt GO_REF:0000003 NCBI chr 9:20,563,335...20,575,008
Ensembl chr 9:20,563,391...20,577,880 		JBrowse link
G Pin4 peptidyl-prolyl cis/trans isomerase, NIMA-interacting, 4 (parvulin) enables IEA UniProt GO_REF:0000003 NCBI chr  X:101,163,075...101,171,276
Ensembl chr  X:101,163,053...101,171,275 		JBrowse link
G Ppia peptidylprolyl isomerase A enables IEA UniProt GO_REF:0000003 NCBI chr11:6,365,867...6,369,817
Ensembl chr11:6,365,443...6,369,817 		JBrowse link
G Ppib peptidylprolyl isomerase B enables IEA UniProt GO_REF:0000003 NCBI chr 9:65,967,451...65,973,911
Ensembl chr 9:65,967,504...65,973,905 		JBrowse link
G Ppic peptidylprolyl isomerase C enables IEA UniProt GO_REF:0000003 NCBI chr18:53,539,413...53,551,079
Ensembl chr18:53,539,404...53,551,187 		JBrowse link
G Ppid peptidylprolyl isomerase D (cyclophilin D) enables IEA UniProt GO_REF:0000003 NCBI chr 3:79,498,644...79,511,117
Ensembl chr 3:79,498,649...79,510,957 		JBrowse link
G Ppie peptidylprolyl isomerase E (cyclophilin E) enables IEA UniProt GO_REF:0000003 NCBI chr 4:123,020,907...123,033,783
Ensembl chr 4:123,020,908...123,033,744 		JBrowse link
G Ppif peptidylprolyl isomerase F (cyclophilin F) enables IEA UniProt GO_REF:0000003 NCBI chr14:25,693,998...25,700,892
Ensembl chr14:25,694,578...25,700,892 		JBrowse link
G Ppig peptidyl-prolyl isomerase G (cyclophilin G) enables IEA UniProt GO_REF:0000003 NCBI chr 2:69,553,152...69,584,356
Ensembl chr 2:69,552,889...69,584,356 		JBrowse link
G Ppih peptidyl prolyl isomerase H enables IEA UniProt GO_REF:0000003 NCBI chr 4:119,157,207...119,177,720
Ensembl chr 4:119,157,207...119,177,743 		JBrowse link
G Ppil1 peptidylprolyl isomerase (cyclophilin)-like 1 enables IEA UniProt GO_REF:0000003 NCBI chr17:29,469,809...29,482,945
Ensembl chr17:29,469,777...29,483,160 		JBrowse link
G Ppil3 peptidylprolyl isomerase (cyclophilin)-like 3 enables IEA UniProt GO_REF:0000003 NCBI chr 1:58,470,152...58,484,878
Ensembl chr 1:58,470,153...58,484,645 		JBrowse link
G Ppil4 peptidylprolyl isomerase (cyclophilin)-like 4 enables IEA UniProt GO_REF:0000003 NCBI chr10:7,668,653...7,698,329
Ensembl chr10:7,668,655...7,698,899 		JBrowse link
G Ppwd1 peptidylprolyl isomerase domain and WD repeat containing 1 enables IEA UniProt GO_REF:0000003 NCBI chr13:104,340,102...104,365,378
Ensembl chr13:104,341,632...104,365,351 		JBrowse link
G Ptpa protein phosphatase 2 protein activator enables IEA UniProt GO_REF:0000003 NCBI chr 2:30,306,062...30,337,819
Ensembl chr 2:30,306,051...30,337,818 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28792
    catalytic activity 5722
      catalytic activity, acting on a protein 2503
        peptidyl-prolyl cis-trans isomerase activity 38
          RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity + 28
Path 2
Term Annotations click to browse term
  molecular_function 28792
    catalytic activity 5722
      isomerase activity 199
        cis-trans isomerase activity 42
          peptidyl-prolyl cis-trans isomerase activity 38
            RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity + 28
paths to the root