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ONTOLOGY REPORT - ANNOTATIONS


Term:damaged DNA binding
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Accession:GO:0003684 term browser browse the term
Definition:Binding to damaged DNA.
Synonyms:related_synonym: DNA repair enzyme;   DNA repair protein



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damaged DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AFF3 AF4/FMR2 family member 3 enables IEA InterPro
UniProt
GO_REF:0000002 GO_REF:0000104 NCBI chr 3:54,135,476...54,730,201
Ensembl chr 3:54,135,532...54,862,224
JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISO (PMID:12524539), (PMID:14706345), (PMID:24703901) BHF-UCL PMID:12524539 PMID:14706345 PMID:24703901 NCBI chr 7:78,451,845...78,454,938
Ensembl chr 7:78,451,851...78,454,938
JBrowse link
G APTX aprataxin enables IEA Ensembl GO_REF:0000107 NCBI chr10:33,470,089...33,495,584
Ensembl chr10:33,445,168...33,771,582
JBrowse link
G AUNIP aurora kinase A and ninein interacting protein enables IEA Ensembl GO_REF:0000107 NCBI chr 6:83,276,977...83,316,642
Ensembl chr 6:83,272,771...83,316,419
JBrowse link
G BRCA1 BRCA1 DNA repair associated enables IEA Ensembl GO_REF:0000107 NCBI chr12:19,788,087...19,854,515
Ensembl chr12:19,786,020...19,855,570
JBrowse link
G CREBBP CREB binding protein enables IEA Ensembl GO_REF:0000107 NCBI chr 3:38,388,366...38,530,243
Ensembl chr 3:38,388,547...38,530,230
JBrowse link
G CRY2 cryptochrome circadian regulator 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 2:16,587,101...16,620,380
Ensembl chr 2:16,585,966...16,620,405
JBrowse link
G CUL4B cullin 4B contributes_to
enables
ISO
IEA
(PMID:22334663) UniProtKB
Ensembl
PMID:22334663 GO_REF:0000107 NCBI chr  X:98,668,945...98,730,582
Ensembl chr  X:98,668,945...98,730,602
JBrowse link
G DCLRE1A DNA cross-link repair 1A enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:124,144,272...124,162,379
Ensembl chr14:124,144,270...124,162,241
JBrowse link
G DCLRE1B DNA cross-link repair 1B enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:106,646,591...106,656,490
Ensembl chr 4:106,646,010...106,656,452
JBrowse link
G DCLRE1C DNA cross-link repair 1C enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:46,820,016...46,863,848
Ensembl chr10:46,820,051...46,868,030
JBrowse link
G DDB1 damage specific DNA binding protein 1 contributes_to
enables
ISO
IEA
(PMID:22334663) UniProtKB
Ensembl
RGD
PMID:12145536 PMID:22334663 GO_REF:0000107 RGD:632554 NCBI chr 2:10,171,554...10,201,602
Ensembl chr 2:10,171,499...10,201,602
JBrowse link
G DDB2 damage specific DNA binding protein 2 contributes_to
enables
IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr 2:15,342,614...15,370,623
Ensembl chr 2:15,337,743...15,383,116
JBrowse link
G EP300 E1A binding protein p300 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760
JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit enables ISO (PMID:17720715) UniProt PMID:17720715 NCBI chr 6:51,783,537...51,808,898 JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:51,734,318...51,757,508
Ensembl chr 6:51,734,319...51,779,624
JBrowse link
G ERCC4 ERCC excision repair 4, endonuclease catalytic subunit enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:29,266,234...29,306,109
Ensembl chr 3:29,266,236...29,306,116
JBrowse link
G ERCC5 ERCC excision repair 5, endonuclease enables ISO (PMID:32821917) UniProt PMID:32821917 NCBI chr11:71,141,823...71,168,326
Ensembl chr11:71,141,798...71,168,321
JBrowse link
G HMGB1 high mobility group box 1 enables ISO (PMID:17803946) UniProt PMID:17803946 NCBI chr11:7,195,556...7,321,071 JBrowse link
G HMGB2 high mobility group box 2 enables IEA Ensembl GO_REF:0000107 NCBI chr14:16,709,966...16,712,288
Ensembl chr14:16,710,047...16,717,126
JBrowse link
G LOC100522201 histone H2AX enables IEA Ensembl GO_REF:0000107 NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084
JBrowse link
G LOC100627380 lysine-specific demethylase 4D-like enables ISO (MGI:5552986|PMID:24550317) MGI PMID:24550317 MGI:5552986 NCBI chr 9:27,083,348...27,085,693 JBrowse link
G MSH2 mutS homolog 2 enables ISO (MGI:1351797|PMID:10545954), (MGI:74950|PMID:7628020) MGI PMID:7628020 PMID:10545954 MGI:1351797 MGI:74950 NCBI chr 3:93,082,958...93,163,556
Ensembl chr 3:93,081,219...93,163,628
JBrowse link
G MSH3 mutS homolog 3 enables ISO (MGI:1351797|PMID:10545954) MGI PMID:10545954 MGI:1351797 NCBI chr 2:89,255,647...89,456,102
Ensembl chr 2:89,250,189...89,453,936
JBrowse link
G MSH6 mutS homolog 6 enables ISO (MGI:1351797|PMID:10545954) MGI PMID:10545954 MGI:1351797 NCBI chr 3:92,792,590...92,814,154
Ensembl chr 3:92,785,664...92,814,128
JBrowse link
G NBN nibrin enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:46,787,664...46,854,331
Ensembl chr 4:46,787,659...46,903,999
JBrowse link
G NEIL1 nei like DNA glycosylase 1 enables IEA InterPro GO_REF:0000002 NCBI chr 7:58,261,761...58,269,001
Ensembl chr 7:58,261,761...58,283,092
JBrowse link
G NEIL2 nei like DNA glycosylase 2 enables IEA InterPro GO_REF:0000002 NCBI chr14:14,945,129...14,966,305
Ensembl chr14:14,945,168...15,002,368
JBrowse link
G NEIL3 nei like DNA glycosylase 3 enables IEA InterPro GO_REF:0000002 NCBI chr15:39,416,073...39,632,313
Ensembl chr15:39,581,856...39,632,310
JBrowse link
G NTHL1 nth like DNA glycosylase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:39,935,619...39,941,718
Ensembl chr 3:39,934,912...39,941,712
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase enables IEA
ISO
InterPro
RGD
PMID:9801319 GO_REF:0000002 RGD:729091 NCBI chr13:66,038,669...66,045,478 JBrowse link
G PCNA proliferating cell nuclear antigen enables IEA Ensembl GO_REF:0000107 NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,125,814...14,185,276
JBrowse link
G POLB DNA polymerase beta ISO RGD PMID:12388548 RGD:633643 NCBI chr17:11,356,130...11,388,122
Ensembl chr17:11,356,129...11,388,821
JBrowse link
G POLD1 DNA polymerase delta 1, catalytic subunit enables IEA Ensembl GO_REF:0000107 NCBI chr 6:55,247,799...55,272,087
Ensembl chr 6:55,247,861...55,272,166
JBrowse link
G POLH DNA polymerase eta enables IEA InterPro GO_REF:0000002 NCBI chr 7:38,569,211...38,601,794
Ensembl chr 7:38,567,775...38,601,790
JBrowse link
G POLI DNA polymerase iota enables IEA InterPro GO_REF:0000002 NCBI chr 1:103,793,779...103,820,365
Ensembl chr 1:103,794,071...103,824,646
JBrowse link
G POLK DNA polymerase kappa enables IEA InterPro GO_REF:0000002 NCBI chr 2:84,555,648...84,619,490
Ensembl chr 2:84,538,050...84,656,234
JBrowse link
G RAD23A RAD23 homolog A, nucleotide excision repair protein enables IEA UniProt GO_REF:0000104 NCBI chr 2:66,090,089...66,096,477
Ensembl chr 2:66,084,856...66,096,484
JBrowse link
G RAD23B RAD23 homolog B, nucleotide excision repair protein enables IEA UniProt GO_REF:0000104 NCBI chr 1:248,447,991...248,493,651
Ensembl chr 1:248,448,265...248,492,860
JBrowse link
G RBBP8 RB binding protein 8, endonuclease enables IEA Ensembl GO_REF:0000107 NCBI chr 6:107,923,921...108,020,067
Ensembl chr 6:107,924,002...108,022,669
JBrowse link
G REV1 REV1 DNA directed polymerase enables IEA UniProt
InterPro
GO_REF:0000002 GO_REF:0000104 NCBI chr 3:54,775,602...54,862,704
Ensembl chr 3:54,135,532...54,862,224
JBrowse link
G RPA1 replication protein A1 enables IEA Ensembl GO_REF:0000107 NCBI chr12:48,009,652...48,048,744
Ensembl chr12:48,009,724...48,048,734
JBrowse link
G RPA2 replication protein A2 enables IEA Ensembl GO_REF:0000107 NCBI chr 6:85,032,604...85,045,899
Ensembl chr 6:85,031,578...85,045,916
JBrowse link
G RPA3 replication protein A3 enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:77,910,876...77,914,872
Ensembl chr 9:77,910,881...77,937,060
JBrowse link
G RPS3 ribosomal protein S3 enables ISO (PMID:14706345), (PMID:16737853), (PMID:17560175), (PMID:18610840) UniProt PMID:14706345 PMID:16737853 PMID:17560175 PMID:18610840 NCBI chr 9:9,612,939...9,630,404
Ensembl chr 9:9,616,456...9,630,413
JBrowse link
G SDE2 SDE2 telomere maintenance homolog enables IEA Ensembl GO_REF:0000107 NCBI chr10:13,879,482...13,897,847
Ensembl chr10:13,879,728...13,897,862
JBrowse link
G SMC6 structural maintenance of chromosomes 6 enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:120,097,361...120,170,974
Ensembl chr 3:120,097,379...120,170,972
JBrowse link
G TMEM169 transmembrane protein 169 enables IEA InterPro GO_REF:0000002 NCBI chr15:118,335,915...118,352,713
Ensembl chr15:118,335,925...118,452,296
JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 1:127,958,500...128,032,370
Ensembl chr 1:127,958,518...128,028,718
JBrowse link
G TP63 tumor protein p63 enables IEA Ensembl GO_REF:0000107 NCBI chr13:127,115,990...127,347,082
Ensembl chr13:127,116,104...127,347,075
JBrowse link
G UNG uracil DNA glycosylase enables IEA Ensembl GO_REF:0000107 NCBI chr14:41,746,498...41,757,841
Ensembl chr14:41,746,501...41,757,862
JBrowse link
G XPA XPA, DNA damage recognition and repair factor enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:239,532,331...239,568,589
Ensembl chr 1:239,532,246...239,568,649
JBrowse link
G XPC XPC complex subunit, DNA damage recognition and repair factor enables IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr13:70,348,841...70,397,194
Ensembl chr13:70,348,864...70,397,782
JBrowse link
G XRCC1 X-ray repair cross complementing 1 enables IEA InterPro GO_REF:0000002 NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,686...50,425,710
JBrowse link
G XRCC5 X-ray repair cross complementing 5 enables IEA InterPro GO_REF:0000002 NCBI chr15:118,354,943...118,451,974
Ensembl chr15:118,335,925...118,452,296
JBrowse link
G XRCC6 X-ray repair cross complementing 6 enables IEA InterPro GO_REF:0000002 NCBI chr 5:6,903,496...6,929,162
Ensembl chr 5:6,903,496...6,929,083
JBrowse link
8-hydroxy-2'-deoxyguanosine DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BLM BLM RecQ like helicase enables IEA Ensembl GO_REF:0000107 NCBI chr 7:53,317,515...53,412,649
Ensembl chr 7:53,317,540...53,412,647
JBrowse link
G POT1 protection of telomeres 1 enables IEA Ensembl GO_REF:0000107 NCBI chr18:22,885,704...22,981,893
Ensembl chr18:22,827,029...22,981,890
JBrowse link
G WRN WRN RecQ like helicase enables IEA Ensembl GO_REF:0000107 NCBI chr15:53,966,968...54,094,855
Ensembl chr15:53,966,972...54,094,587
JBrowse link
DNA-(abasic site) binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 7:78,451,845...78,454,938
Ensembl chr 7:78,451,851...78,454,938
JBrowse link
oxidized DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G XRCC1 X-ray repair cross complementing 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,686...50,425,710
JBrowse link
oxidized purine DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MSH2 mutS homolog 2 contributes_to
enables
IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 3:93,082,958...93,163,556
Ensembl chr 3:93,081,219...93,163,628
JBrowse link
G MSH3 mutS homolog 3 NOT|contributes_to ISO (PMID:11756455) HGNC PMID:11756455 NCBI chr 2:89,255,647...89,456,102
Ensembl chr 2:89,250,189...89,453,936
JBrowse link
G MSH6 mutS homolog 6 contributes_to IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:92,792,590...92,814,154
Ensembl chr 3:92,785,664...92,814,128
JBrowse link
G MUTYH mutY DNA glycosylase enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:166,002,853...166,012,191 JBrowse link
G OGG1 8-oxoguanine DNA glycosylase enables ISO (PMID:14706345) UniProt PMID:14706345 NCBI chr13:66,038,669...66,045,478 JBrowse link
G RECQL4 RecQ like helicase 4 enables ISO (PMID:22039056) BHF-UCL PMID:22039056 NCBI chr 4:287,206...293,629 JBrowse link
G RPS3 ribosomal protein S3 enables IEA Ensembl GO_REF:0000107 NCBI chr 9:9,612,939...9,630,404
Ensembl chr 9:9,616,456...9,630,413
JBrowse link
oxidized pyrimidine DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RPS3 ribosomal protein S3 enables IEA Ensembl GO_REF:0000107 NCBI chr 9:9,612,939...9,630,404
Ensembl chr 9:9,616,456...9,630,413
JBrowse link
single-strand break-containing DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APTX aprataxin enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:33,470,089...33,495,584
Ensembl chr10:33,445,168...33,771,582
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17464
    binding 15382
      heterocyclic compound binding 4949
        nucleic acid binding 3084
          DNA binding 2046
            damaged DNA binding 61
              DNA-(abasic site) binding 1
              alkylated DNA binding + 0
              oxidized DNA binding + 11
              single-strand break-containing DNA binding 1
paths to the root