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ONTOLOGY REPORT - ANNOTATIONS


Term:damaged DNA binding
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Accession:GO:0003684 term browser browse the term
Definition:Binding to damaged DNA.
Synonyms:related_synonym: DNA repair enzyme;   DNA repair protein



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damaged DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP002495.1 XRCC1 N-terminal domain containing 1-like enables IEA InterPro GO_REF:0000002 Ensembl chr11:71,865,509...71,928,654 JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables IDA (PMID:12524539), (PMID:14706345), (PMID:24703901) BHF-UCL PMID:12524539 PMID:14706345 PMID:24703901 NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772
JBrowse link
G APTX aprataxin enables IDA (PMID:14755728) UniProt PMID:14755728 NCBI chr 9:32,883,872...33,025,120
Ensembl chr 9:32,886,601...33,025,130
JBrowse link
G AUNIP aurora kinase A and ninein interacting protein enables IDA (PMID:29042561) UniProt PMID:29042561 NCBI chr 1:25,831,906...25,859,457
Ensembl chr 1:25,831,913...25,859,458
JBrowse link
G BRCA1 BRCA1 DNA repair associated enables IEA Ensembl GO_REF:0000107 NCBI chr17:43,044,295...43,125,364
Ensembl chr17:43,044,295...43,170,245
JBrowse link
G CREBBP CREB binding protein enables IDA (PMID:24939902) UniProt PMID:24939902 NCBI chr16:3,725,054...3,880,727
Ensembl chr16:3,725,054...3,880,713
JBrowse link
G CRY2 cryptochrome circadian regulator 2 enables IDA (PMID:12627958) UniProt PMID:12627958 NCBI chr11:45,847,118...45,883,244
Ensembl chr11:45,847,118...45,883,248
JBrowse link
G CUL4B cullin 4B contributes_to IDA (PMID:22334663) UniProtKB PMID:22334663 NCBI chr  X:120,523,858...120,575,532
Ensembl chr  X:120,505,920...120,604,074
JBrowse link
G DCLRE1A DNA cross-link repair 1A enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:113,834,725...113,854,394
Ensembl chr10:113,834,725...113,854,383
JBrowse link
G DCLRE1B DNA cross-link repair 1B enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:113,904,619...113,914,086
Ensembl chr 1:113,905,213...113,914,086
JBrowse link
G DCLRE1C DNA cross-link repair 1C enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:14,897,359...14,954,432
Ensembl chr10:14,897,359...14,954,432
JBrowse link
G DDB1 damage specific DNA binding protein 1 contributes_to IDA
ISO
(PMID:22334663) UniProtKB
RGD
PMID:12145536 PMID:22334663 RGD:632554 NCBI chr11:61,299,451...61,333,105
Ensembl chr11:61,299,451...61,342,596
JBrowse link
G DDB2 damage specific DNA binding protein 2 contributes_to
enables
IDA
IEA
IBA
(PMID:22334663)
(PMID:21873635)
UniProtKB
InterPro
GO_Central
PMID:21873635 PMID:22334663 GO_REF:0000002 NCBI chr11:47,214,969...47,239,218
Ensembl chr11:47,214,465...47,239,217
JBrowse link
G EP300 E1A binding protein p300 enables IDA (PMID:24939902) UniProt PMID:24939902 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,592...41,180,077
JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit enables IEA
IDA
IBA
(PMID:17720715)
(PMID:21873635)
InterPro
UniProt
GO_Central
PMID:17720715 PMID:21873635 GO_REF:0000002 NCBI chr19:45,407,334...45,451,547
Ensembl chr19:45,407,334...45,478,828
JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:45,349,837...45,370,647
Ensembl chr19:45,349,837...45,370,918
JBrowse link
G ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit enables NAS (PMID:2167179) UniProt PMID:2167179 NCBI chr 2:127,257,290...127,294,166
Ensembl chr 2:127,257,290...127,294,166
JBrowse link
G ERCC4 ERCC excision repair 4, endonuclease catalytic subunit enables IBA
IMP
(PMID:21873635)
(PMID:11790111)
GO_Central
UniProt
PMID:11790111 PMID:21873635 NCBI chr16:13,920,137...13,952,348
Ensembl chr16:13,920,138...13,952,348
JBrowse link
G ERCC5 ERCC excision repair 5, endonuclease enables IDA (PMID:32821917) UniProt PMID:32821917 NCBI chr13:102,846,032...102,875,995
Ensembl chr13:102,845,831...102,875,995
JBrowse link
G FANCG FA complementation group G enables TAS (PMID:9806548) PINC PMID:9806548 NCBI chr 9:35,073,839...35,079,942
Ensembl chr 9:35,073,835...35,079,942
JBrowse link
G FEN1 flap structure-specific endonuclease 1 enables TAS (PMID:8007985) PINC PMID:8007985 NCBI chr11:61,792,911...61,797,238
Ensembl chr11:61,792,911...61,797,238
JBrowse link
G H2AX H2A.X variant histone enables IEA Ensembl GO_REF:0000107 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,854...119,095,467
JBrowse link
G HMGB1 high mobility group box 1 enables ISS
IDA
(PMID:17803946) UniProt PMID:17803946 GO_REF:0000024 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
JBrowse link
G HMGB2 high mobility group box 2 enables IDA (PMID:8226934) UniProt PMID:8226934 NCBI chr 4:173,331,376...173,334,358
Ensembl chr 4:173,331,376...173,334,432
JBrowse link
G KDM4D lysine demethylase 4D enables IEA Ensembl GO_REF:0000107 NCBI chr11:94,973,709...94,999,519
Ensembl chr11:94,973,709...94,999,519
JBrowse link
G L34079.1 novel protein enables IEA InterPro GO_REF:0000002 Ensembl chr19:43,554,692...43,593,036 JBrowse link
G MPG N-methylpurine DNA glycosylase enables TAS (PMID:10854423) PINC PMID:10854423 NCBI chr16:77,007...85,846
Ensembl chr16:77,007...85,851
JBrowse link
G MSH2 mutS homolog 2 enables ISO (MGI:1351797|PMID:10545954), (MGI:74950|PMID:7628020) MGI PMID:7628020 PMID:10545954 MGI:1351797 MGI:74950 NCBI chr 2:47,403,067...47,634,501
Ensembl chr 2:47,403,067...47,663,146
JBrowse link
G MSH3 mutS homolog 3 enables ISO (MGI:1351797|PMID:10545954) MGI PMID:10545954 MGI:1351797 NCBI chr 5:80,654,652...80,876,815
Ensembl chr 5:80,654,652...80,876,815
JBrowse link
G MSH6 mutS homolog 6 enables ISO (MGI:1351797|PMID:10545954) MGI PMID:10545954 MGI:1351797 NCBI chr 2:47,783,145...47,806,954
Ensembl chr 2:47,695,530...47,810,063
JBrowse link
G NBN nibrin contributes_to
enables
IC
IBA
(PMID:9590180)
(PMID:21873635)
UniProtKB
GO_Central
PMID:9590180 PMID:21873635 NCBI chr 8:89,933,331...89,984,698
Ensembl chr 8:89,933,331...90,003,228
JBrowse link
G NEIL1 nei like DNA glycosylase 1 enables IEA InterPro GO_REF:0000002 NCBI chr15:75,346,638...75,357,115
Ensembl chr15:75,346,955...75,357,115
JBrowse link
G NEIL2 nei like DNA glycosylase 2 enables IEA InterPro GO_REF:0000002 NCBI chr 8:11,769,710...11,787,345
Ensembl chr 8:11,769,639...11,787,345
JBrowse link
G NEIL3 nei like DNA glycosylase 3 enables ISS UniProt GO_REF:0000024 NCBI chr 4:177,309,871...177,362,936
Ensembl chr 4:177,309,874...177,362,936
JBrowse link
G NTHL1 nth like DNA glycosylase 1 enables IDA (PMID:9927729) UniProt PMID:9927729 NCBI chr16:2,039,820...2,047,834
Ensembl chr16:2,039,815...2,047,866
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase enables IDA
ISO
IEA
(PMID:14706345) UniProt
RGD
InterPro
PMID:9801319 PMID:14706345 GO_REF:0000002 RGD:729091 NCBI chr 3:9,749,952...9,788,246
Ensembl chr 3:9,749,944...9,788,219
JBrowse link
G PCNA proliferating cell nuclear antigen enables IDA (PMID:24939902) UniProt PMID:24939902 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PNKP polynucleotide kinase 3'-phosphatase enables NAS (PMID:10446193) UniProt PMID:10446193 NCBI chr19:49,861,204...49,867,576
Ensembl chr19:49,859,882...49,878,351
JBrowse link
G POLB DNA polymerase beta enables IEA
ISO
Ensembl
RGD
PMID:12388548 GO_REF:0000107 RGD:633643 NCBI chr 8:42,338,452...42,371,810
Ensembl chr 8:42,338,454...42,371,808
JBrowse link
G POLD1 DNA polymerase delta 1, catalytic subunit enables IDA (PMID:24939902) UniProt PMID:24939902 NCBI chr19:50,384,291...50,418,018
Ensembl chr19:50,384,204...50,418,018
JBrowse link
G POLH DNA polymerase eta enables IEA InterPro GO_REF:0000002 NCBI chr 6:43,576,147...43,620,523
Ensembl chr 6:43,576,185...43,620,523
JBrowse link
G POLI DNA polymerase iota enables IEA InterPro GO_REF:0000002 NCBI chr18:54,269,479...54,321,266
Ensembl chr18:54,269,517...54,321,266
JBrowse link
G POLK DNA polymerase kappa enables IEA InterPro GO_REF:0000002 NCBI chr 5:75,511,891...75,601,144
Ensembl chr 5:75,511,756...75,601,144
JBrowse link
G POLQ DNA polymerase theta enables TAS (PMID:10395804) PINC PMID:10395804 NCBI chr 3:121,431,431...121,545,988
Ensembl chr 3:121,431,431...121,545,988
JBrowse link
G RAD1 RAD1 checkpoint DNA exonuclease enables TAS (PMID:9872989) PINC PMID:9872989 NCBI chr 5:34,905,260...34,915,504
Ensembl chr 5:34,905,260...34,918,989
JBrowse link
G RAD18 RAD18 E3 ubiquitin protein ligase enables NAS (PMID:10884424) UniProt PMID:10884424 NCBI chr 3:8,877,075...8,969,249
Ensembl chr 3:8,775,402...8,963,773
JBrowse link
G RAD23A RAD23 homolog A, nucleotide excision repair protein enables IEA InterPro
UniProt
GO_REF:0000002 GO_REF:0000104 NCBI chr19:12,945,846...12,953,642
Ensembl chr19:12,945,855...12,953,642
JBrowse link
G RAD23B RAD23 homolog B, nucleotide excision repair protein enables IEA InterPro GO_REF:0000002 NCBI chr 9:107,283,279...107,332,194
Ensembl chr 9:107,283,137...107,332,192
JBrowse link
G RBBP8 RB binding protein 8, endonuclease enables IBA
IDA
(PMID:21873635)
(PMID:18716619)
GO_Central
UniProt
PMID:18716619 PMID:21873635 NCBI chr18:22,914,121...23,026,486
Ensembl chr18:22,798,261...23,026,488
JBrowse link
G REV1 REV1 DNA directed polymerase enables IEA InterPro GO_REF:0000002 NCBI chr 2:99,400,477...99,490,123
Ensembl chr 2:99,400,475...99,490,035
JBrowse link
G RPA1 replication protein A1 enables IBA
IDA
(PMID:21873635)
(PMID:27723717), (PMID:27723720), (PMID:7700386)
GO_Central
UniProt
PMID:7700386 PMID:21873635 PMID:27723717 PMID:27723720 NCBI chr17:1,830,005...1,900,082
Ensembl chr17:1,829,702...1,900,082
JBrowse link
G RPA2 replication protein A2 enables IDA (PMID:27723717), (PMID:27723720), (PMID:7700386) UniProt PMID:7700386 PMID:27723717 PMID:27723720 NCBI chr 1:27,891,524...27,914,797
Ensembl chr 1:27,891,524...27,914,746
JBrowse link
G RPA3 replication protein A3 enables IDA
IBA
(PMID:7700386)
(PMID:21873635)
UniProt
GO_Central
PMID:7700386 PMID:21873635 NCBI chr 7:7,636,518...7,718,607
Ensembl chr 7:7,636,518...7,718,607
JBrowse link
G RPS3 ribosomal protein S3 enables IDA (PMID:14706345), (PMID:16737853), (PMID:17560175), (PMID:18610840) UniProt PMID:14706345 PMID:16737853 PMID:17560175 PMID:18610840 NCBI chr11:75,399,518...75,422,302
Ensembl chr11:75,399,515...75,422,280
JBrowse link
G SDE2 SDE2 telomere maintenance homolog enables IDA (PMID:27906959) UniProt PMID:27906959 NCBI chr 1:225,982,702...225,999,343
Ensembl chr 1:225,982,702...225,999,343
JBrowse link
G SMC6 structural maintenance of chromosomes 6 enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:17,663,812...17,753,833
Ensembl chr 2:17,663,812...17,800,242
JBrowse link
G TDG thymine DNA glycosylase enables TAS (PMID:9489705) PINC PMID:9489705 NCBI chr12:103,965,842...103,988,874
Ensembl chr12:103,965,822...103,988,874
JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 enables IEA Ensembl GO_REF:0000107 NCBI chr15:43,403,061...43,510,640
Ensembl chr15:43,403,061...43,510,728
JBrowse link
G TP63 tumor protein p63 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:189,596,746...189,897,276
Ensembl chr 3:189,631,389...189,897,276
JBrowse link
G UNG uracil DNA glycosylase enables IDA (PMID:18973764) UniProt PMID:18973764 NCBI chr12:109,097,597...109,110,992
Ensembl chr12:109,097,597...109,110,992
JBrowse link
G XNDC1N XRCC1 N-terminal domain containing 1, N-terminal like enables IEA InterPro GO_REF:0000002 NCBI chr11:71,865,509...71,928,594
Ensembl chr11:71,865,504...71,928,665
JBrowse link
G XPA XPA, DNA damage recognition and repair factor enables IBA
IDA
IEA
(PMID:21873635)
(PMID:7700386)
GO_Central
UniProt
InterPro
PMID:7700386 PMID:21873635 GO_REF:0000002 NCBI chr 9:97,654,398...97,697,403
Ensembl chr 9:97,674,909...97,697,340
JBrowse link
G XPC XPC complex subunit, DNA damage recognition and repair factor enables IDA
IBA
(PMID:10873465), (PMID:12509299)
(PMID:21873635)
UniProt
GO_Central
PMID:10873465 PMID:12509299 PMID:21873635 NCBI chr 3:14,145,145...14,178,601
Ensembl chr 3:14,145,147...14,178,621
JBrowse link
G XRCC1 X-ray repair cross complementing 1 enables IEA InterPro GO_REF:0000002 NCBI chr19:43,543,311...43,575,527
Ensembl chr19:43,543,311...43,580,473
JBrowse link
G XRCC5 X-ray repair cross complementing 5 enables IEA InterPro GO_REF:0000002 NCBI chr 2:216,109,348...216,206,293
Ensembl chr 2:216,107,464...216,206,303
JBrowse link
G XRCC6 X-ray repair cross complementing 6 enables IEA InterPro GO_REF:0000002 NCBI chr22:41,621,295...41,664,041
Ensembl chr22:41,621,163...41,664,048
JBrowse link
8-hydroxy-2'-deoxyguanosine DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BLM BLM RecQ like helicase enables IDA (PMID:19734539) BHF-UCL PMID:19734539 NCBI chr15:90,717,346...90,816,166
Ensembl chr15:90,717,346...90,816,166
JBrowse link
G POT1 protection of telomeres 1 enables IDA (PMID:19734539) BHF-UCL PMID:19734539 NCBI chr 7:124,822,386...124,929,825
Ensembl chr 7:124,822,386...124,929,983
JBrowse link
G WRN WRN RecQ like helicase enables IDA (PMID:19734539) BHF-UCL PMID:19734539 NCBI chr 8:31,033,749...31,176,138
Ensembl chr 8:31,033,788...31,176,138
JBrowse link
DNA-(abasic site) binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables IMP (PMID:9804798) UniProt PMID:9804798 NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772
JBrowse link
oxidized DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G XRCC1 X-ray repair cross complementing 1 enables IMP (PMID:28002403) UniProt PMID:28002403 NCBI chr19:43,543,311...43,575,527
Ensembl chr19:43,543,311...43,580,473
JBrowse link
oxidized purine DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MSH2 mutS homolog 2 contributes_to IDA
IBA
(PMID:11756455), (PMID:11801590)
(PMID:21873635)
HGNC
GO_Central
PMID:11756455 PMID:11801590 PMID:21873635 NCBI chr 2:47,403,067...47,634,501
Ensembl chr 2:47,403,067...47,663,146
JBrowse link
G MSH3 mutS homolog 3 NOT|contributes_to IDA (PMID:11756455) HGNC PMID:11756455 NCBI chr 5:80,654,652...80,876,815
Ensembl chr 5:80,654,652...80,876,815
JBrowse link
G MSH6 mutS homolog 6 contributes_to IDA
IBA
(PMID:11756455), (PMID:11801590)
(PMID:21873635)
HGNC
GO_Central
PMID:11756455 PMID:11801590 PMID:21873635 NCBI chr 2:47,783,145...47,806,954
Ensembl chr 2:47,695,530...47,810,063
JBrowse link
G MUTYH mutY DNA glycosylase enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:45,329,242...45,340,447
Ensembl chr 1:45,329,163...45,340,893
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase enables IDA (PMID:14706345) UniProt PMID:14706345 NCBI chr 3:9,749,952...9,788,246
Ensembl chr 3:9,749,944...9,788,219
JBrowse link
G RECQL4 RecQ like helicase 4 enables IDA (PMID:22039056) BHF-UCL PMID:22039056 NCBI chr 8:144,511,288...144,517,833
Ensembl chr 8:144,511,288...144,517,845
JBrowse link
G RPS3 ribosomal protein S3 enables IDA (PMID:14706345) UniProt PMID:14706345 NCBI chr11:75,399,518...75,422,302
Ensembl chr11:75,399,515...75,422,280
JBrowse link
oxidized pyrimidine DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RPS3 ribosomal protein S3 enables IDA (PMID:19656744) UniProt PMID:19656744 NCBI chr11:75,399,518...75,422,302
Ensembl chr11:75,399,515...75,422,280
JBrowse link
single-strand break-containing DNA binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APTX aprataxin enables IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:32,883,872...33,025,120
Ensembl chr 9:32,886,601...33,025,130
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18840
    binding 17200
      heterocyclic compound binding 6189
        nucleic acid binding 4135
          DNA binding 2593
            damaged DNA binding 71
              DNA-(abasic site) binding 1
              alkylated DNA binding + 0
              oxidized DNA binding + 11
              single-strand break-containing DNA binding 1
paths to the root