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ONTOLOGY REPORT - ANNOTATIONS


Term:sphingosine-1-phosphate receptor signaling pathway
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Accession:GO:0003376 term browser browse the term
Definition:A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: S1P receptor signaling pathway;   S1P-activated G-protein coupled receptor signaling pathway;   S1P-activated GPCR signaling pathway;   S1P-stimulated signal transduction pathway;   sphingolipid signalling pathway
 broad_synonym: sphingolipid signaling pathway
 related_synonym: S1P signaling pathway
 alt_id: GO:0001789


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sphingosine-1-phosphate receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in ISO (PMID:18558630) RGD PMID:18558630 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Ezr ezrin involved_in ISO (PMID:23106337) RGD PMID:23106337 NCBI chr 1:46,967,961...47,011,505 JBrowse link
G Gpr6 G protein-coupled receptor 6 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr20:44,489,853...44,492,624 JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta involved_in ISO
IEA
(PMID:18558630)
UniProtKB:O35904 (MGI:4461861|PMID:18558630)
GO_REF:0000107
RGD
Ensembl
PMID:18558630 GO_REF:0000107 MGI:4461861 NCBI chr 8:99,594,600...99,699,772 JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma involved_in ISO (PMID:18558630)
(MGI:4461861|PMID:18558630)
RGD PMID:18558630 MGI:4461861 NCBI chr 6:48,766,778...48,802,098 JBrowse link
G Rac1 Rac family small GTPase 1 involved_in ISO (PMID:18558630) RGD PMID:18558630 NCBI chr12:11,037,028...11,057,251 JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:2151313|PMID:11032855)
(PMID:22344443)
PMID:21873635
UniProt
RGD
PMID:11032855 PMID:22344443, PMID:21873635 GO_REF:0000024 MGI:2151313, RGD:13792537 NCBI chr 2:203,624,752...203,629,110 JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 involved_in ISO
IBA
(PMID:23106337)
(MGI:5470025|PMID:23106337)
PMID:21873635
RGD PMID:23106337, PMID:21873635 MGI:5470025, RGD:13792537 NCBI chr 8:19,503,276...19,514,169 JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr17:13,781,050...13,794,408 JBrowse link
G S1pr4 sphingosine-1-phosphate receptor 4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:8,207,767...8,210,043 JBrowse link
G S1pr5 sphingosine-1-phosphate receptor 5 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:19,786,676...19,791,862 JBrowse link
G Sphk1 sphingosine kinase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:101,758,567...101,764,240 JBrowse link
G Sphk2 sphingosine kinase 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:96,180,872...96,188,592 JBrowse link
G Spns2 sphingolipid transporter 2 acts_upstream_of_or_within ISO MGI:4460276|MGI:5426395 (MGI:5424314|PMID:22406534), (MGI:5490425|PMID:23180825) RGD PMID:22406534 PMID:23180825 MGI:5424314 MGI:5490425 NCBI chr10:57,067,348...57,105,969 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    cellular process 18342
      signal transduction 6880
        sphingolipid mediated signaling pathway 17
          sphingosine-1-phosphate receptor signaling pathway 14
Path 2
Term Annotations click to browse term
  biological_process 19492
    biological regulation 13513
      regulation of biological process 12769
        regulation of cellular process 12271
          signal transduction 6880
            G protein-coupled receptor signaling pathway 2333
              sphingosine-1-phosphate receptor signaling pathway 14
paths to the root