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ONTOLOGY REPORT - ANNOTATIONS

Term:pancreatic A cell differentiation
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Accession:GO:0003310 term browser browse the term
Definition:The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
Synonyms:exact_synonym: pancreatic alpha cell differentiation


show annotations for term's descendants           Sort by:
pancreatic A cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata6 GATA binding protein 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:16887115)		 Ensembl
RGD		 PMID:16887115 GO_REF:0000107 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:2149672 (PMID:10615124)		 Ensembl
RGD		 PMID:10615124 GO_REF:0000107 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Insm1 INSM transcriptional repressor 1 involved_in
acts_upstream_of_or_within		 ISO (MGI:3619850|PMID:16511571)
(PMID:16511571)		 RGD PMID:16511571 MGI:3619850 NCBI chr 3:133,640,030...133,642,963
Ensembl chr 3:133,639,580...133,643,003 		JBrowse link
G Nkx6-1 NK6 homeobox 1 acts_upstream_of_or_within ISO MGI:1352738 (PMID:15944193) RGD PMID:15944193 NCBI chr14:7,969,756...7,976,689
Ensembl chr14:7,969,756...7,976,681 		JBrowse link
G Nkx6-2 NK6 homeobox 2 acts_upstream_of_or_within ISO MGI:1206039 (PMID:15944193) RGD PMID:15944193 NCBI chr 1:194,380,149...194,383,533
Ensembl chr 1:194,381,975...194,383,515 		JBrowse link
G Onecut1 one cut homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2179340 (PMID:10825208)		 Ensembl
RGD		 PMID:10825208 GO_REF:0000107 NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277 		JBrowse link
G Pax6 paired box 6 IMP RGD PMID:20592023 RGD:8552352 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
G Rfx6 regulatory factor X, 6 involved_in ISO (MGI:4422104|PMID:20148032)
(PMID:20148032)		 RGD PMID:20148032 MGI:4422104 NCBI chr20:31,019,784...31,073,266
Ensembl chr20:31,019,829...31,073,147 		JBrowse link
G Vhl von Hippel-Lindau tumor suppressor acts_upstream_of_or_within ISO MGI:2136645|MGI:3608931 (PMID:25186293) RGD PMID:25186293 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377 		JBrowse link
negative regulation of pancreatic A cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hes1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2149672 (PMID:10615124)		 Ensembl
RGD		 PMID:10615124 GO_REF:0000107 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Mir7-1 microRNA 7-1 acts_upstream_of_or_within ISO (PMID:22764048) RGD PMID:22764048 NCBI chr17:6,273,264...6,273,360
Ensembl chr17:6,273,264...6,273,360 		JBrowse link
pancreatic A cell development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pax6 paired box 6 involved_in IMP
IEA
ISO		 PMID:20592023
GO_REF:0000107
(MGI:4943812|PMID:20592023)
(PMID:20592023)		 Ensembl
RGD		 PMID:20592023 PMID:20592023 GO_REF:0000107 MGI:4943812, RGD:8552352 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
pancreatic A cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Neurod1 neuronal differentiation 1 acts_upstream_of_or_within ISO MGI:97347 (PMID:17988662) RGD PMID:17988662 NCBI chr 3:64,359,554...64,363,526
Ensembl chr 3:64,359,395...64,363,649 		JBrowse link
G Nkx2-2 NK2 homeobox 2 acts_upstream_of_or_within ISO MGI:1339708|MGI:1932100 (PMID:17202186), (PMID:17988662) RGD PMID:17202186 PMID:17988662 NCBI chr 3:134,619,701...134,630,282
Ensembl chr 3:134,620,039...134,622,411 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20134
    developmental process 7034
      anatomical structure development 6553
        endocrine pancreas development 55
          pancreatic A cell differentiation 12
            negative regulation of pancreatic A cell differentiation 2
            pancreatic A cell development 1
            pancreatic A cell fate commitment 2
            positive regulation of pancreatic A cell differentiation 0
            regulation of pancreatic A cell differentiation + 2
Path 2
Term Annotations click to browse term
  biological_process 20134
    developmental process 7034
      anatomical structure development 6553
        tissue development 2305
          epithelium development 1439
            epithelial cell differentiation 852
              columnar/cuboidal epithelial cell differentiation 155
                glandular epithelial cell differentiation 83
                  enteroendocrine cell differentiation 42
                    pancreatic A cell differentiation 12
                      negative regulation of pancreatic A cell differentiation 2
                      pancreatic A cell development 1
                      pancreatic A cell fate commitment 2
                      positive regulation of pancreatic A cell differentiation 0
                      regulation of pancreatic A cell differentiation + 2
paths to the root